The relationship between aortic stiffness and serum hyaluronidase levels in patients with diabetes mellitus and hypertension
Abstract The aim of this study was to investigate the association of serum hyaluronidase and nitric oxide (NO) levels with arterial stiffness in patients with hypertension (HT) and diabetes mellitus (DM). A total of 101 patients with diagnosis of DM and HT were enrolled in this study. The patients w...
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| Veröffentlicht in: | Blood pressure 2015-02, Vol.24 (1), p.35-40 |
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| creator | Karadag, Bilgehan Ikitimur, Baris Firinciogullari, Habbas Cakmak, Huseyin Altug Cosansu, Kahraman Yuksel, Husniye |
| description | Abstract
The aim of this study was to investigate the association of serum hyaluronidase and nitric oxide (NO) levels with arterial stiffness in patients with hypertension (HT) and diabetes mellitus (DM). A total of 101 patients with diagnosis of DM and HT were enrolled in this study. The patients were divided into three groups as follows: only hypertensive (I), only diabetic (II) and both diabetic and hypertensive (III). Serum hyaluronidase levels were negatively correlated with aortic strain (AS) and aortic distensibility (AOD) in all groups, whereas a significant positive correlation was noted between serum hyaluronidase levels and aortic strain index (ASI) (all p-values < 0.05). There was a significant negative correlation between serum hyaluronidase and NO levels in all patients (p < 0.001). When the correlation between serum hyaluronidase and serum NO levels was investigated in the individual patient groups, a negative correlation was found in groups I, II and III (p = 0.017, p < 0.001 and p < 0.001, respectively). A significant relationship between plasma hyaluronidase level and parameters of aortic stiffness was found in patients with HT and/or DM. We suggest that the pathophysiological mechanisms responsible for the development of arterial stiffness in subjects with impaired endothelial function may involve pathological changes in the HA metabolism. |
| doi_str_mv | 10.3109/08037051.2014.940708 |
| format | Article |
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The aim of this study was to investigate the association of serum hyaluronidase and nitric oxide (NO) levels with arterial stiffness in patients with hypertension (HT) and diabetes mellitus (DM). A total of 101 patients with diagnosis of DM and HT were enrolled in this study. The patients were divided into three groups as follows: only hypertensive (I), only diabetic (II) and both diabetic and hypertensive (III). Serum hyaluronidase levels were negatively correlated with aortic strain (AS) and aortic distensibility (AOD) in all groups, whereas a significant positive correlation was noted between serum hyaluronidase levels and aortic strain index (ASI) (all p-values < 0.05). There was a significant negative correlation between serum hyaluronidase and NO levels in all patients (p < 0.001). When the correlation between serum hyaluronidase and serum NO levels was investigated in the individual patient groups, a negative correlation was found in groups I, II and III (p = 0.017, p < 0.001 and p < 0.001, respectively). A significant relationship between plasma hyaluronidase level and parameters of aortic stiffness was found in patients with HT and/or DM. We suggest that the pathophysiological mechanisms responsible for the development of arterial stiffness in subjects with impaired endothelial function may involve pathological changes in the HA metabolism.</description><identifier>ISSN: 0803-7051</identifier><identifier>EISSN: 1651-1999</identifier><identifier>DOI: 10.3109/08037051.2014.940708</identifier><identifier>PMID: 25093258</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Aged ; aortic stiffness ; diabetes ; Diabetes Complications - blood ; Diabetes Complications - physiopathology ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - physiopathology ; Female ; Humans ; Hyaluronidase ; Hyaluronoglucosaminidase - blood ; hypertension ; Hypertension - blood ; Hypertension - physiopathology ; Male ; Middle Aged ; Nitric Oxide - blood ; Vascular Stiffness</subject><ispartof>Blood pressure, 2015-02, Vol.24 (1), p.35-40</ispartof><rights>2014 Scandinavian Foundation for Cardiovascular Research 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-7ff4d6f163d19258f3420d40fb99c2160d23287ac6c9178328999d256a6017f03</citedby><cites>FETCH-LOGICAL-c418t-7ff4d6f163d19258f3420d40fb99c2160d23287ac6c9178328999d256a6017f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25093258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karadag, Bilgehan</creatorcontrib><creatorcontrib>Ikitimur, Baris</creatorcontrib><creatorcontrib>Firinciogullari, Habbas</creatorcontrib><creatorcontrib>Cakmak, Huseyin Altug</creatorcontrib><creatorcontrib>Cosansu, Kahraman</creatorcontrib><creatorcontrib>Yuksel, Husniye</creatorcontrib><title>The relationship between aortic stiffness and serum hyaluronidase levels in patients with diabetes mellitus and hypertension</title><title>Blood pressure</title><addtitle>Blood Press</addtitle><description>Abstract
The aim of this study was to investigate the association of serum hyaluronidase and nitric oxide (NO) levels with arterial stiffness in patients with hypertension (HT) and diabetes mellitus (DM). A total of 101 patients with diagnosis of DM and HT were enrolled in this study. The patients were divided into three groups as follows: only hypertensive (I), only diabetic (II) and both diabetic and hypertensive (III). Serum hyaluronidase levels were negatively correlated with aortic strain (AS) and aortic distensibility (AOD) in all groups, whereas a significant positive correlation was noted between serum hyaluronidase levels and aortic strain index (ASI) (all p-values < 0.05). There was a significant negative correlation between serum hyaluronidase and NO levels in all patients (p < 0.001). When the correlation between serum hyaluronidase and serum NO levels was investigated in the individual patient groups, a negative correlation was found in groups I, II and III (p = 0.017, p < 0.001 and p < 0.001, respectively). A significant relationship between plasma hyaluronidase level and parameters of aortic stiffness was found in patients with HT and/or DM. We suggest that the pathophysiological mechanisms responsible for the development of arterial stiffness in subjects with impaired endothelial function may involve pathological changes in the HA metabolism.</description><subject>Aged</subject><subject>aortic stiffness</subject><subject>diabetes</subject><subject>Diabetes Complications - blood</subject><subject>Diabetes Complications - physiopathology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyaluronidase</subject><subject>Hyaluronoglucosaminidase - blood</subject><subject>hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitric Oxide - blood</subject><subject>Vascular Stiffness</subject><issn>0803-7051</issn><issn>1651-1999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFTEUhgdR7G31H4hk6WauJ8l8ZaNIUSsU3NR1yJ2cMCmZ5JpkvFzojzfDtIKbrpLFc973nKeq3lHYcwriIwzAe2jpngFt9qKBHoYX1Y52La2pEOJltVuRemUuqsuU7gEo5wCvqwvWguCsHXbVw92EJKJT2QafJnskB8wnRE9UiNmOJGVrjMeUiPKaJIzLTKazcksM3mqVkDj8gy4R68mxpKDPiZxsnoi2qmRhIjM6Z_OyJUznI8aMPpW-N9Uro1zCt4_vVfXr29e765v69uf3H9dfbuuxoUOue2Ma3RnacU1F2drwhoFuwByEGBntQDPOhl6N3ShoP5R_OV-ztlMd0N4Av6o-bLnHGH4vmLKcbRrLVspjWJIszhgXDFhT0GZDxxhSimjkMdpZxbOkIFfv8sm7XL3LzXsZe__YsBxm1P-GnkQX4PMGWG9CnNUpRKdlVmcXoonKjzat8c9WfPovYULl8jSqiPI-LNEXgc_v-BfTX6bR</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Karadag, Bilgehan</creator><creator>Ikitimur, Baris</creator><creator>Firinciogullari, Habbas</creator><creator>Cakmak, Huseyin Altug</creator><creator>Cosansu, Kahraman</creator><creator>Yuksel, Husniye</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>The relationship between aortic stiffness and serum hyaluronidase levels in patients with diabetes mellitus and hypertension</title><author>Karadag, Bilgehan ; Ikitimur, Baris ; Firinciogullari, Habbas ; Cakmak, Huseyin Altug ; Cosansu, Kahraman ; Yuksel, Husniye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-7ff4d6f163d19258f3420d40fb99c2160d23287ac6c9178328999d256a6017f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>aortic stiffness</topic><topic>diabetes</topic><topic>Diabetes Complications - blood</topic><topic>Diabetes Complications - physiopathology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hyaluronidase</topic><topic>Hyaluronoglucosaminidase - blood</topic><topic>hypertension</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitric Oxide - blood</topic><topic>Vascular Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karadag, Bilgehan</creatorcontrib><creatorcontrib>Ikitimur, Baris</creatorcontrib><creatorcontrib>Firinciogullari, Habbas</creatorcontrib><creatorcontrib>Cakmak, Huseyin Altug</creatorcontrib><creatorcontrib>Cosansu, Kahraman</creatorcontrib><creatorcontrib>Yuksel, Husniye</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood pressure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karadag, Bilgehan</au><au>Ikitimur, Baris</au><au>Firinciogullari, Habbas</au><au>Cakmak, Huseyin Altug</au><au>Cosansu, Kahraman</au><au>Yuksel, Husniye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between aortic stiffness and serum hyaluronidase levels in patients with diabetes mellitus and hypertension</atitle><jtitle>Blood pressure</jtitle><addtitle>Blood Press</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>24</volume><issue>1</issue><spage>35</spage><epage>40</epage><pages>35-40</pages><issn>0803-7051</issn><eissn>1651-1999</eissn><abstract>Abstract
The aim of this study was to investigate the association of serum hyaluronidase and nitric oxide (NO) levels with arterial stiffness in patients with hypertension (HT) and diabetes mellitus (DM). A total of 101 patients with diagnosis of DM and HT were enrolled in this study. The patients were divided into three groups as follows: only hypertensive (I), only diabetic (II) and both diabetic and hypertensive (III). Serum hyaluronidase levels were negatively correlated with aortic strain (AS) and aortic distensibility (AOD) in all groups, whereas a significant positive correlation was noted between serum hyaluronidase levels and aortic strain index (ASI) (all p-values < 0.05). There was a significant negative correlation between serum hyaluronidase and NO levels in all patients (p < 0.001). When the correlation between serum hyaluronidase and serum NO levels was investigated in the individual patient groups, a negative correlation was found in groups I, II and III (p = 0.017, p < 0.001 and p < 0.001, respectively). A significant relationship between plasma hyaluronidase level and parameters of aortic stiffness was found in patients with HT and/or DM. We suggest that the pathophysiological mechanisms responsible for the development of arterial stiffness in subjects with impaired endothelial function may involve pathological changes in the HA metabolism.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>25093258</pmid><doi>10.3109/08037051.2014.940708</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged aortic stiffness diabetes Diabetes Complications - blood Diabetes Complications - physiopathology Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Female Humans Hyaluronidase Hyaluronoglucosaminidase - blood hypertension Hypertension - blood Hypertension - physiopathology Male Middle Aged Nitric Oxide - blood Vascular Stiffness |
| title | The relationship between aortic stiffness and serum hyaluronidase levels in patients with diabetes mellitus and hypertension |
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