Single-particle tracking reveals that free ribosomal subunits are not excluded from the Escherichia coli nucleoid

Biochemical and genetic data show that ribosomes closely follow RNA polymerases that are transcribing protein-coding genes in bacteria. At the same time, electron and fluorescence microscopy have revealed that ribosomes are excluded from the Escherichia coli nucleoid, which seems to be inconsistent...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-08, Vol.111 (31), p.11413-11418
Hauptverfasser:	Sanamrad, Arash, Persson, Fredrik, Lundius, Ebba G., Fange, David, Gynnå, Arvid H., Elf, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	antibiotics bacteria Biochemistry Biological Sciences Cell growth Cell Tracking - methods Cells Diffusion coefficient DNA DNA, Bacterial - metabolism E coli Erythromycin - pharmacology Escherichia coli Escherichia coli - cytology Escherichia coli - drug effects Escherichia coli - metabolism Escherichia coli Proteins - metabolism fluorescence microscopy genes Messenger RNA Microbial Viability - drug effects Microfluidics nucleoid exclusion Particle trajectories Protein Biosynthesis - drug effects protein subunits Ribonucleic acid ribosomal proteins Ribosome Subunits - metabolism Ribosomes RNA RNA polymerase RNA, Messenger - metabolism single-molecule imaging single-molecule tracking Spatial distribution Stem cells Trajectories transcription-translation coupling translation (genetics)
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