Methylation by NSun2 Represses the Levels and Function of MicroRNA 125b

Methylation is a prevalent posttranscriptional modification of RNAs. However, whether mammalian microRNAs are methylated is unknown. Here, we show that the tRNA methyltransferase NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular and cellular biology 2014-10, Vol.34 (19), p.3630-3641
Hauptverfasser:	Yuan, Shuai, Tang, Hao, Xing, Junyue, Fan, Xiuqin, Cai, Xiaoyu, Li, Qiu, Han, Pei, Luo, Yuhong, Zhang, Zhuojun, Jiang, Bin, Dou, Yali, Gorospe, Myriam, Wang, Wengong
Format:	Artikel
Sprache:	eng
Schlagworte:	Carboxypeptidases - metabolism DNA Methylation Epigenesis, Genetic Gene Silencing HeLa Cells Humans Hydrogen Peroxide - pharmacology Methyltransferases - genetics MicroRNAs - metabolism Oxidative Stress RNA Processing, Post-Transcriptional RNA, Messenger - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!