Tissue engineered poly(caprolactone)-chitosan-poly(vinyl alcohol) nanofibrous scaffolds for burn and cutting wound healing
Natural-synthetic blend nanofibres have recently attracted more interest because of the ability of achieving desirable properties. Poly(ε-caprolactone) (PCL)-chitosan (Cs)-poly(vinyl alcohol) (PVA) blend nanofibrous scaffolds were electrospun in 2:1:1.33 mass ratio of PCL:Cs:PVA. The presence of PCL...
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| Veröffentlicht in: | IET nanobiotechnology 2014-06, Vol.8 (2), p.123-131 |
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| creator | Gholipour-Kanani, Adeleh Bahrami, S. Hajir Joghataie, Mohammad Taghi Samadikuchaksaraei, Ali Ahmadi-Taftie, Hossein Rabbani, Shahram Kororian, Alireza Erfani, Elham |
| description | Natural-synthetic blend nanofibres have recently attracted more interest because of the ability of achieving desirable properties. Poly(ε-caprolactone) (PCL)-chitosan (Cs)-poly(vinyl alcohol) (PVA) blend nanofibrous scaffolds were electrospun in 2:1:1.33 mass ratio of PCL:Cs:PVA. The presence of PCL in the blend leads to improvement in web hydrophobicity and helped the web to retain its integrity in aqueous media. The scaffolds were used in two forms of acellular and with mesenchymal stem cells. They were applied on burn (n = 12) and excisional cutting (n = 12) wounds on dorsum skin of rats. Macroscopic investigations were carried out to measure the wounds areas. It was found that the area of wounds that were treated with cell-seeded nanofibrous scaffolds were smaller compared to other samples. Pathological results showed much better healing performance for cell-seeded scaffolds followed by acellular scaffolds compared with control samples. All these results indicate that PCL:Cs:PVA nanofibrous web would be a proper material for burn and cutting wound healing. |
| doi_str_mv | 10.1049/iet-nbt.2012.0050 |
| format | Article |
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Hajir ; Joghataie, Mohammad Taghi ; Samadikuchaksaraei, Ali ; Ahmadi-Taftie, Hossein ; Rabbani, Shahram ; Kororian, Alireza ; Erfani, Elham</creator><creatorcontrib>Gholipour-Kanani, Adeleh ; Bahrami, S. Hajir ; Joghataie, Mohammad Taghi ; Samadikuchaksaraei, Ali ; Ahmadi-Taftie, Hossein ; Rabbani, Shahram ; Kororian, Alireza ; Erfani, Elham</creatorcontrib><description>Natural-synthetic blend nanofibres have recently attracted more interest because of the ability of achieving desirable properties. Poly(ε-caprolactone) (PCL)-chitosan (Cs)-poly(vinyl alcohol) (PVA) blend nanofibrous scaffolds were electrospun in 2:1:1.33 mass ratio of PCL:Cs:PVA. The presence of PCL in the blend leads to improvement in web hydrophobicity and helped the web to retain its integrity in aqueous media. The scaffolds were used in two forms of acellular and with mesenchymal stem cells. They were applied on burn (n = 12) and excisional cutting (n = 12) wounds on dorsum skin of rats. Macroscopic investigations were carried out to measure the wounds areas. It was found that the area of wounds that were treated with cell-seeded nanofibrous scaffolds were smaller compared to other samples. Pathological results showed much better healing performance for cell-seeded scaffolds followed by acellular scaffolds compared with control samples. All these results indicate that PCL:Cs:PVA nanofibrous web would be a proper material for burn and cutting wound healing.</description><identifier>ISSN: 1751-8741</identifier><identifier>ISSN: 1751-875X</identifier><identifier>EISSN: 1751-875X</identifier><identifier>DOI: 10.1049/iet-nbt.2012.0050</identifier><identifier>PMID: 25014084</identifier><language>eng</language><publisher>Stevenage: The Institution of Engineering and Technology</publisher><subject>acellular scaffold formation ; Animals ; aqueous media ; Biological and medical sciences ; biomedical materials ; Biotechnology ; burn wound healing ; Burns - therapy ; cellular biophysics ; cell‐seeded nanofibrous scaffold ; Chitosan - chemistry ; cutting wound healing ; electrospinning ; electrospun ; Fundamental and applied biological sciences. Psychology ; Hot Temperature ; Humans ; Hydrophobic and Hydrophilic Interactions ; hydrophobicity ; Male ; mesenchymal stem cell ; Mesenchymal Stromal Cells - cytology ; Nanofibers - chemistry ; nanofibres ; nanomedicine ; nanoparticles ; natural‐synthetic blend nanofibre ; patient treatment ; PCL‐chitosan‐PVA blend nanofibrous scaffold ; PCL‐chitosan‐PVA mass ratio ; poly(caprolactone) ; poly(vinyl alcohol) ; Polyesters - chemistry ; polymer blends ; Polyvinyl Alcohol - chemistry ; rat dorsum skin ; Rats ; Rats, Sprague-Dawley ; skin ; Skin - drug effects ; tissue engineering ; Tissue Engineering - methods ; Tissue Scaffolds - chemistry ; Umbilical Cord - metabolism ; web hydrophobicity ; wound area measurement ; Wound Healing ; wounds ; Wounds and Injuries - therapy</subject><ispartof>IET nanobiotechnology, 2014-06, Vol.8 (2), p.123-131</ispartof><rights>The Institution of Engineering and Technology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright The Institution of Engineering & Technology Jun 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5588-d9fa5603d0f85a79ab98622cd42d81808dd9ee42f3e6ee66c41b3c5babf1746d3</citedby><cites>FETCH-LOGICAL-c5588-d9fa5603d0f85a79ab98622cd42d81808dd9ee42f3e6ee66c41b3c5babf1746d3</cites><orcidid>0000-0002-2108-9927</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1049%2Fiet-nbt.2012.0050$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1049%2Fiet-nbt.2012.0050$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,11562,27924,27925,45574,45575,46052,46476</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28500267$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25014084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gholipour-Kanani, Adeleh</creatorcontrib><creatorcontrib>Bahrami, S. Hajir</creatorcontrib><creatorcontrib>Joghataie, Mohammad Taghi</creatorcontrib><creatorcontrib>Samadikuchaksaraei, Ali</creatorcontrib><creatorcontrib>Ahmadi-Taftie, Hossein</creatorcontrib><creatorcontrib>Rabbani, Shahram</creatorcontrib><creatorcontrib>Kororian, Alireza</creatorcontrib><creatorcontrib>Erfani, Elham</creatorcontrib><title>Tissue engineered poly(caprolactone)-chitosan-poly(vinyl alcohol) nanofibrous scaffolds for burn and cutting wound healing</title><title>IET nanobiotechnology</title><addtitle>IET Nanobiotechnol</addtitle><description>Natural-synthetic blend nanofibres have recently attracted more interest because of the ability of achieving desirable properties. Poly(ε-caprolactone) (PCL)-chitosan (Cs)-poly(vinyl alcohol) (PVA) blend nanofibrous scaffolds were electrospun in 2:1:1.33 mass ratio of PCL:Cs:PVA. The presence of PCL in the blend leads to improvement in web hydrophobicity and helped the web to retain its integrity in aqueous media. The scaffolds were used in two forms of acellular and with mesenchymal stem cells. They were applied on burn (n = 12) and excisional cutting (n = 12) wounds on dorsum skin of rats. Macroscopic investigations were carried out to measure the wounds areas. It was found that the area of wounds that were treated with cell-seeded nanofibrous scaffolds were smaller compared to other samples. Pathological results showed much better healing performance for cell-seeded scaffolds followed by acellular scaffolds compared with control samples. All these results indicate that PCL:Cs:PVA nanofibrous web would be a proper material for burn and cutting wound healing.</description><subject>acellular scaffold formation</subject><subject>Animals</subject><subject>aqueous media</subject><subject>Biological and medical sciences</subject><subject>biomedical materials</subject><subject>Biotechnology</subject><subject>burn wound healing</subject><subject>Burns - therapy</subject><subject>cellular biophysics</subject><subject>cell‐seeded nanofibrous scaffold</subject><subject>Chitosan - chemistry</subject><subject>cutting wound healing</subject><subject>electrospinning</subject><subject>electrospun</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>hydrophobicity</subject><subject>Male</subject><subject>mesenchymal stem cell</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Nanofibers - chemistry</subject><subject>nanofibres</subject><subject>nanomedicine</subject><subject>nanoparticles</subject><subject>natural‐synthetic blend nanofibre</subject><subject>patient treatment</subject><subject>PCL‐chitosan‐PVA blend nanofibrous scaffold</subject><subject>PCL‐chitosan‐PVA mass ratio</subject><subject>poly(caprolactone)</subject><subject>poly(vinyl alcohol)</subject><subject>Polyesters - chemistry</subject><subject>polymer blends</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>rat dorsum skin</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>skin</subject><subject>Skin - drug effects</subject><subject>tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Umbilical Cord - metabolism</subject><subject>web hydrophobicity</subject><subject>wound area measurement</subject><subject>Wound Healing</subject><subject>wounds</subject><subject>Wounds and Injuries - therapy</subject><issn>1751-8741</issn><issn>1751-875X</issn><issn>1751-875X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUFvFCEYhidGY2v1B3gxJMake5gVGJhhe7NNq00avayJN8LAR5eGhRVmbNZfL-OuqzEaPQHheYGXp6qeEzwnmC1eOxjq0A9zigmdY8zxg-qYdJzUouOfHh7mjBxVT3K-KwTnjXhcHVGOCcOCHVdfly7nERCEWxcAEhi0iX57qtUmRa_0EAPMar1yQ8wq1N_3vriw9Uh5HVfRz1BQIVrXpzhmlLWyNnqTkY0J9WMKSAWD9DgMLtyi-ziW1QqUL6un1SOrfIZn-_Gk-nh1ubx4V998eHt98eam1pwLUZuFVbzFjcFWcNUtVL8QLaXaMGoEEVgYswBg1DbQArStZqRvNO9Vb0nHWtOcVKe7c0ujzyPkQa5d1uC9ClDeLAlnnWBtJ8j_oKxrhMAT-vI39C6WuqXIRBUjmBFaKLKjdIo5J7Byk9xapa0kWE4OZXEoi0M5OZSTw5J5sT957NdgDokf0grwag-o8t_eJhW0yz85wTGmbVe4sx137zxs_32zfH--pOdXGONGlPBsF56wQ7Xry-VE_ZLZGFvY-g_s3xt-A9sr1YQ</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Gholipour-Kanani, Adeleh</creator><creator>Bahrami, S. 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Hajir ; Joghataie, Mohammad Taghi ; Samadikuchaksaraei, Ali ; Ahmadi-Taftie, Hossein ; Rabbani, Shahram ; Kororian, Alireza ; Erfani, Elham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5588-d9fa5603d0f85a79ab98622cd42d81808dd9ee42f3e6ee66c41b3c5babf1746d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>acellular scaffold formation</topic><topic>Animals</topic><topic>aqueous media</topic><topic>Biological and medical sciences</topic><topic>biomedical materials</topic><topic>Biotechnology</topic><topic>burn wound healing</topic><topic>Burns - therapy</topic><topic>cellular biophysics</topic><topic>cell‐seeded nanofibrous scaffold</topic><topic>Chitosan - chemistry</topic><topic>cutting wound healing</topic><topic>electrospinning</topic><topic>electrospun</topic><topic>Fundamental and applied biological sciences. 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Hajir</au><au>Joghataie, Mohammad Taghi</au><au>Samadikuchaksaraei, Ali</au><au>Ahmadi-Taftie, Hossein</au><au>Rabbani, Shahram</au><au>Kororian, Alireza</au><au>Erfani, Elham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue engineered poly(caprolactone)-chitosan-poly(vinyl alcohol) nanofibrous scaffolds for burn and cutting wound healing</atitle><jtitle>IET nanobiotechnology</jtitle><addtitle>IET Nanobiotechnol</addtitle><date>2014-06</date><risdate>2014</risdate><volume>8</volume><issue>2</issue><spage>123</spage><epage>131</epage><pages>123-131</pages><issn>1751-8741</issn><issn>1751-875X</issn><eissn>1751-875X</eissn><abstract>Natural-synthetic blend nanofibres have recently attracted more interest because of the ability of achieving desirable properties. Poly(ε-caprolactone) (PCL)-chitosan (Cs)-poly(vinyl alcohol) (PVA) blend nanofibrous scaffolds were electrospun in 2:1:1.33 mass ratio of PCL:Cs:PVA. The presence of PCL in the blend leads to improvement in web hydrophobicity and helped the web to retain its integrity in aqueous media. The scaffolds were used in two forms of acellular and with mesenchymal stem cells. They were applied on burn (n = 12) and excisional cutting (n = 12) wounds on dorsum skin of rats. Macroscopic investigations were carried out to measure the wounds areas. It was found that the area of wounds that were treated with cell-seeded nanofibrous scaffolds were smaller compared to other samples. Pathological results showed much better healing performance for cell-seeded scaffolds followed by acellular scaffolds compared with control samples. All these results indicate that PCL:Cs:PVA nanofibrous web would be a proper material for burn and cutting wound healing.</abstract><cop>Stevenage</cop><pub>The Institution of Engineering and Technology</pub><pmid>25014084</pmid><doi>10.1049/iet-nbt.2012.0050</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2108-9927</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1751-8741 |
| ispartof | IET nanobiotechnology, 2014-06, Vol.8 (2), p.123-131 |
| issn | 1751-8741 1751-875X 1751-875X |
| language | eng |
| recordid | cdi_pubmed_primary_25014084 |
| source | MEDLINE; Wiley Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library Open Access |
| subjects | acellular scaffold formation Animals aqueous media Biological and medical sciences biomedical materials Biotechnology burn wound healing Burns - therapy cellular biophysics cell‐seeded nanofibrous scaffold Chitosan - chemistry cutting wound healing electrospinning electrospun Fundamental and applied biological sciences. Psychology Hot Temperature Humans Hydrophobic and Hydrophilic Interactions hydrophobicity Male mesenchymal stem cell Mesenchymal Stromal Cells - cytology Nanofibers - chemistry nanofibres nanomedicine nanoparticles natural‐synthetic blend nanofibre patient treatment PCL‐chitosan‐PVA blend nanofibrous scaffold PCL‐chitosan‐PVA mass ratio poly(caprolactone) poly(vinyl alcohol) Polyesters - chemistry polymer blends Polyvinyl Alcohol - chemistry rat dorsum skin Rats Rats, Sprague-Dawley skin Skin - drug effects tissue engineering Tissue Engineering - methods Tissue Scaffolds - chemistry Umbilical Cord - metabolism web hydrophobicity wound area measurement Wound Healing wounds Wounds and Injuries - therapy |
| title | Tissue engineered poly(caprolactone)-chitosan-poly(vinyl alcohol) nanofibrous scaffolds for burn and cutting wound healing |
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