Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

Extracellular fatty acid incorporation into the phospholipids of Staphylococcus aureus occurs via fatty acid phosphorylation. We show that fatty acid kinase (Fak) is composed of two dissociable protein subunits encoded by separate genes. FakA provides the ATP binding domain and interacts with two di...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-07, Vol.111 (29), p.10532-10537
Hauptverfasser:	Parsons, Joshua B., Broussard, Tyler C., Bose, Jeffrey L., Rosch, Jason W., Jackson, Pamela, Subramanian, Chitra, Rock, Charles O.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biological Sciences Carrier proteins detergents fatty acid-binding proteins Fatty acids Fatty Acids - metabolism Genes Gram-positive bacteria hemolysins Host-Pathogen Interactions Kinases Lipid metabolism Lipids Liposomes messenger RNA micelles Molecular Sequence Data mutants Pathogens Phospholipids Phospholipids - metabolism phosphorylation Phosphotransferases (Carboxyl Group Acceptor) - chemistry Phosphotransferases (Carboxyl Group Acceptor) - metabolism protein secretion protein subunits saturated fatty acids Staphylococcus aureus Staphylococcus aureus - enzymology Staphylococcus aureus - pathogenicity Substrate Specificity transcription factors Transcription, Genetic Transcriptional regulatory elements unsaturated fatty acids virulence Virulence factors Virulence Factors - genetics Virulence Factors - metabolism
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