Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress

Premature senescence induced by oncogenic stimuli or tumor suppressor activation plays opposing roles in tumorigenesis. Here, we propose that galectin-3, a β-galactoside-binding lectin, regulates premature senescence without oncogenic stress. We detected premature senescence, decreased Skp2, and inc...

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Veröffentlicht in:	Cell death and differentiation 2014-11, Vol.21 (11), p.1769
Hauptverfasser:	Kim, S-J, Lee, H-W, Gu Kang, H, La, S-H, Choi, Il Ju, Ro, J Y, Bresalier, R S, Song, J, Chun, K-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis Cell Line, Tumor Cellular Senescence - physiology Cyclin D1 - antagonists & inhibitors Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cyclin-Dependent Kinase Inhibitor Proteins - metabolism Cyclin-Dependent Kinases - antagonists & inhibitors Galectin 3 - antagonists & inhibitors Galectin 3 - genetics Galectin 3 - metabolism Humans Mice Oncogenes Retinoblastoma Protein - genetics S-Phase Kinase-Associated Proteins - metabolism
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