σ(N) -dependent control of acid resistance and the locus of enterocyte effacement in enterohemorrhagic Escherichia coli is activated by acetyl phosphate in a manner requiring flagellar regulator FlhDC and the σ(S) antagonist FliZ

In enterohemorrhagic Escherichia coli (EHEC), sigma factor N (σ(N)) regulates glutamate-dependent acid resistance (GDAR) and the locus of enterocyte effacement (LEE); discrete genetic systems that are required for transmission and virulence of this intestinal pathogen. Regulation of these systems re...

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Veröffentlicht in:	MicrobiologyOpen (Weinheim) 2014-08, Vol.3 (4), p.497
Hauptverfasser:	Mitra, Avishek, Fay, Pamela A, Vendura, Khoury W, Alla, Zimrisha, Carroll, Ronan K, Shaw, Lindsey N, Riordan, James T
Format:	Artikel
Sprache:	eng
Schlagworte:	Carboxylic Acids - metabolism Drug Tolerance Enterohemorrhagic Escherichia coli - genetics Enterohemorrhagic Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Deletion Gene Expression Regulation, Bacterial Glutamates - metabolism Organophosphates - metabolism Phosphoproteins Repressor Proteins - genetics Repressor Proteins - metabolism Sigma Factor - metabolism Trans-Activators - metabolism Transcriptional Activation
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