Lymphocyte Migration Patterns in Autoimmune MRL-lpr/lpr Mice: Relationship to Age, Disease Manifestations and Lymphocyte Homing Receptor Expression
We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly.1 This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/1) mice in relation to age, disease manifestations and the expression o...
Gespeichert in:
| Veröffentlicht in: | Autoimmunity (Chur, Switzerland) Switzerland), 1989, Vol.3 (1), p.5-15 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 15 |
|---|---|
| container_issue | 1 |
| container_start_page | 5 |
| container_title | Autoimmunity (Chur, Switzerland) |
| container_volume | 3 |
| creator | Schrieber, L. Manolios, N. Cohen, M. G. Paull, Sharon A. Guiffre, Ann K. Hopper, K. E. |
| description | We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly.1 This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/1) mice in relation to age, disease manifestations and the expression of lymphocyte homing receptors, 51chromium-labelled lymph node cells from MRL/1 and from normal histocompatible CBA mice of different ages were injected i.v. into age and sex-matched CBA recipients. Diminished lymph node and increased hepatic uptake of MRL/1 compared to CBA cells was evident as early as 6 weeks of age. Abnormalities in lymphocyte migration antedated the appearance of elevated antihistone antibody (AHA) levels but not the development of lymphadenopathy. Using the monoclonal antibody MEL-14, no differences in the expression of lymphocyte homing receptors between MRL/1 and CBA lymph node cells were found at any age. Thus abnormalities in lymphocyte migration in MRL/1 mice appear as early as six weeks and are not related to changes in homing receptor expression. |
| doi_str_mv | 10.3109/08916938909043609 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_2491620</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79580061</sourcerecordid><originalsourceid>FETCH-LOGICAL-c401t-79795475fef29eff662fa11b4771e7f4d0c4187c238c4e56cac85c9e37a4a7723</originalsourceid><addsrcrecordid>eNp9kcFuEzEQhi1E1YbCA3Co5FNPLLV3nfUauESltJVSFVWtxG01dcaJq117a3sFeQ5euA6JEAiVgzWH-f7PoxlC3nL2vuJMnbBG8VpVjWKKiapm6gWZ8JrJohHlt5dksukXGRAH5FWMD4yxUtZin-yXIgdLNiE_5-t-WHm9Tkiv7DJAst7Rr5ASBhepdXQ2Jm_7fnQZuJkX3RBO8suwxg_0BrtfibiyA02ezpb4jn62ESFmHJw1GNOWoOAW9I_fLnxv3TIbNA7JB3r2YwgYY0Zfkz0DXcQ3u3pI7r6c3Z5eFPPr88vT2bzQgvFUSCXVVMipQVMqNKauSwOc3wspOUojFkwL3khdVo0WOK016GaqFVYSBEhZVofkeOsdgn8c86Btb6PGrgOHfoxt1jeM1TyDfAvq4GMMaNoh2B7CuuWs3Ryi_ecQOXO0k4_3PS5-J3abz_1P2751xocevvvQLdoE684HE8BpGzfq5_Uf_4qvELq00hCwffBjcHlv_xnuCV7oq0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79580061</pqid></control><display><type>article</type><title>Lymphocyte Migration Patterns in Autoimmune MRL-lpr/lpr Mice: Relationship to Age, Disease Manifestations and Lymphocyte Homing Receptor Expression</title><source>MEDLINE</source><source>Access via Taylor & Francis</source><creator>Schrieber, L. ; Manolios, N. ; Cohen, M. G. ; Paull, Sharon A. ; Guiffre, Ann K. ; Hopper, K. E.</creator><creatorcontrib>Schrieber, L. ; Manolios, N. ; Cohen, M. G. ; Paull, Sharon A. ; Guiffre, Ann K. ; Hopper, K. E.</creatorcontrib><description>We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly.1 This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/1) mice in relation to age, disease manifestations and the expression of lymphocyte homing receptors, 51chromium-labelled lymph node cells from MRL/1 and from normal histocompatible CBA mice of different ages were injected i.v. into age and sex-matched CBA recipients. Diminished lymph node and increased hepatic uptake of MRL/1 compared to CBA cells was evident as early as 6 weeks of age. Abnormalities in lymphocyte migration antedated the appearance of elevated antihistone antibody (AHA) levels but not the development of lymphadenopathy. Using the monoclonal antibody MEL-14, no differences in the expression of lymphocyte homing receptors between MRL/1 and CBA lymph node cells were found at any age. Thus abnormalities in lymphocyte migration in MRL/1 mice appear as early as six weeks and are not related to changes in homing receptor expression.</description><identifier>ISSN: 0891-6934</identifier><identifier>EISSN: 1607-842X</identifier><identifier>DOI: 10.3109/08916938909043609</identifier><identifier>PMID: 2491620</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Age Factors ; Animals ; Autoantibodies - blood ; Autoimmune Diseases - immunology ; Autoimmune Diseases - pathology ; Cell Movement - immunology ; Histones - immunology ; Lupus Erythematosus, Systemic - immunology ; Lupus Erythematosus, Systemic - pathology ; Lymph Nodes - immunology ; Lymph Nodes - pathology ; Lymphocyte traffic autoimmunity ; Lymphocytes - immunology ; Lymphocytes - pathology ; Lymphocytes - physiology ; Mice ; Mice, Mutant Strains ; Receptors, Lymphocyte Homing - metabolism ; systemic lupus erythematosus</subject><ispartof>Autoimmunity (Chur, Switzerland), 1989, Vol.3 (1), p.5-15</ispartof><rights>1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-79795475fef29eff662fa11b4771e7f4d0c4187c238c4e56cac85c9e37a4a7723</citedby><cites>FETCH-LOGICAL-c401t-79795475fef29eff662fa11b4771e7f4d0c4187c238c4e56cac85c9e37a4a7723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/08916938909043609$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/08916938909043609$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2491620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schrieber, L.</creatorcontrib><creatorcontrib>Manolios, N.</creatorcontrib><creatorcontrib>Cohen, M. G.</creatorcontrib><creatorcontrib>Paull, Sharon A.</creatorcontrib><creatorcontrib>Guiffre, Ann K.</creatorcontrib><creatorcontrib>Hopper, K. E.</creatorcontrib><title>Lymphocyte Migration Patterns in Autoimmune MRL-lpr/lpr Mice: Relationship to Age, Disease Manifestations and Lymphocyte Homing Receptor Expression</title><title>Autoimmunity (Chur, Switzerland)</title><addtitle>Autoimmunity</addtitle><description>We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly.1 This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/1) mice in relation to age, disease manifestations and the expression of lymphocyte homing receptors, 51chromium-labelled lymph node cells from MRL/1 and from normal histocompatible CBA mice of different ages were injected i.v. into age and sex-matched CBA recipients. Diminished lymph node and increased hepatic uptake of MRL/1 compared to CBA cells was evident as early as 6 weeks of age. Abnormalities in lymphocyte migration antedated the appearance of elevated antihistone antibody (AHA) levels but not the development of lymphadenopathy. Using the monoclonal antibody MEL-14, no differences in the expression of lymphocyte homing receptors between MRL/1 and CBA lymph node cells were found at any age. Thus abnormalities in lymphocyte migration in MRL/1 mice appear as early as six weeks and are not related to changes in homing receptor expression.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - pathology</subject><subject>Cell Movement - immunology</subject><subject>Histones - immunology</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Erythematosus, Systemic - pathology</subject><subject>Lymph Nodes - immunology</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphocyte traffic autoimmunity</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - pathology</subject><subject>Lymphocytes - physiology</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Receptors, Lymphocyte Homing - metabolism</subject><subject>systemic lupus erythematosus</subject><issn>0891-6934</issn><issn>1607-842X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFuEzEQhi1E1YbCA3Co5FNPLLV3nfUauESltJVSFVWtxG01dcaJq117a3sFeQ5euA6JEAiVgzWH-f7PoxlC3nL2vuJMnbBG8VpVjWKKiapm6gWZ8JrJohHlt5dksukXGRAH5FWMD4yxUtZin-yXIgdLNiE_5-t-WHm9Tkiv7DJAst7Rr5ASBhepdXQ2Jm_7fnQZuJkX3RBO8suwxg_0BrtfibiyA02ezpb4jn62ESFmHJw1GNOWoOAW9I_fLnxv3TIbNA7JB3r2YwgYY0Zfkz0DXcQ3u3pI7r6c3Z5eFPPr88vT2bzQgvFUSCXVVMipQVMqNKauSwOc3wspOUojFkwL3khdVo0WOK016GaqFVYSBEhZVofkeOsdgn8c86Btb6PGrgOHfoxt1jeM1TyDfAvq4GMMaNoh2B7CuuWs3Ryi_ecQOXO0k4_3PS5-J3abz_1P2751xocevvvQLdoE684HE8BpGzfq5_Uf_4qvELq00hCwffBjcHlv_xnuCV7oq0A</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Schrieber, L.</creator><creator>Manolios, N.</creator><creator>Cohen, M. G.</creator><creator>Paull, Sharon A.</creator><creator>Guiffre, Ann K.</creator><creator>Hopper, K. E.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Lymphocyte Migration Patterns in Autoimmune MRL-lpr/lpr Mice: Relationship to Age, Disease Manifestations and Lymphocyte Homing Receptor Expression</title><author>Schrieber, L. ; Manolios, N. ; Cohen, M. G. ; Paull, Sharon A. ; Guiffre, Ann K. ; Hopper, K. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-79795475fef29eff662fa11b4771e7f4d0c4187c238c4e56cac85c9e37a4a7723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - pathology</topic><topic>Cell Movement - immunology</topic><topic>Histones - immunology</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lupus Erythematosus, Systemic - pathology</topic><topic>Lymph Nodes - immunology</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphocyte traffic autoimmunity</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - pathology</topic><topic>Lymphocytes - physiology</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Receptors, Lymphocyte Homing - metabolism</topic><topic>systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schrieber, L.</creatorcontrib><creatorcontrib>Manolios, N.</creatorcontrib><creatorcontrib>Cohen, M. G.</creatorcontrib><creatorcontrib>Paull, Sharon A.</creatorcontrib><creatorcontrib>Guiffre, Ann K.</creatorcontrib><creatorcontrib>Hopper, K. E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Autoimmunity (Chur, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schrieber, L.</au><au>Manolios, N.</au><au>Cohen, M. G.</au><au>Paull, Sharon A.</au><au>Guiffre, Ann K.</au><au>Hopper, K. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphocyte Migration Patterns in Autoimmune MRL-lpr/lpr Mice: Relationship to Age, Disease Manifestations and Lymphocyte Homing Receptor Expression</atitle><jtitle>Autoimmunity (Chur, Switzerland)</jtitle><addtitle>Autoimmunity</addtitle><date>1989</date><risdate>1989</risdate><volume>3</volume><issue>1</issue><spage>5</spage><epage>15</epage><pages>5-15</pages><issn>0891-6934</issn><eissn>1607-842X</eissn><abstract>We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly.1 This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/1) mice in relation to age, disease manifestations and the expression of lymphocyte homing receptors, 51chromium-labelled lymph node cells from MRL/1 and from normal histocompatible CBA mice of different ages were injected i.v. into age and sex-matched CBA recipients. Diminished lymph node and increased hepatic uptake of MRL/1 compared to CBA cells was evident as early as 6 weeks of age. Abnormalities in lymphocyte migration antedated the appearance of elevated antihistone antibody (AHA) levels but not the development of lymphadenopathy. Using the monoclonal antibody MEL-14, no differences in the expression of lymphocyte homing receptors between MRL/1 and CBA lymph node cells were found at any age. Thus abnormalities in lymphocyte migration in MRL/1 mice appear as early as six weeks and are not related to changes in homing receptor expression.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>2491620</pmid><doi>10.3109/08916938909043609</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0891-6934 |
| ispartof | Autoimmunity (Chur, Switzerland), 1989, Vol.3 (1), p.5-15 |
| issn | 0891-6934 1607-842X |
| language | eng |
| recordid | cdi_pubmed_primary_2491620 |
| source | MEDLINE; Access via Taylor & Francis |
| subjects | Age Factors Animals Autoantibodies - blood Autoimmune Diseases - immunology Autoimmune Diseases - pathology Cell Movement - immunology Histones - immunology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Lymph Nodes - immunology Lymph Nodes - pathology Lymphocyte traffic autoimmunity Lymphocytes - immunology Lymphocytes - pathology Lymphocytes - physiology Mice Mice, Mutant Strains Receptors, Lymphocyte Homing - metabolism systemic lupus erythematosus |
| title | Lymphocyte Migration Patterns in Autoimmune MRL-lpr/lpr Mice: Relationship to Age, Disease Manifestations and Lymphocyte Homing Receptor Expression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T03%3A35%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lymphocyte%20Migration%20Patterns%20in%20Autoimmune%20MRL-lpr/lpr%20Mice:%20Relationship%20to%20Age,%20Disease%20Manifestations%20and%20Lymphocyte%20Homing%20Receptor%20Expression&rft.jtitle=Autoimmunity%20(Chur,%20Switzerland)&rft.au=Schrieber,%20L.&rft.date=1989&rft.volume=3&rft.issue=1&rft.spage=5&rft.epage=15&rft.pages=5-15&rft.issn=0891-6934&rft.eissn=1607-842X&rft_id=info:doi/10.3109/08916938909043609&rft_dat=%3Cproquest_pubme%3E79580061%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79580061&rft_id=info:pmid/2491620&rfr_iscdi=true |