Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model

Residue depletion of marbofloxacin in broiler chicken after oral administration at 5 mg/kg/day for three consecutive days was studied in this study. The areas under the concentration-time curve from 0 h to ∞ (AUC0-∞ s) of marbofloxacin in tissues and plasma were used to calculate tissue/plasma parti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of veterinary pharmacology and therapeutics 2014-12, Vol.37 (6), p.579
Hauptverfasser: Yang, F, Yang, Y R, Wang, L, Huang, X H, Qiao, G, Zeng, Z L
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 6
container_start_page 579
container_title Journal of veterinary pharmacology and therapeutics
container_volume 37
creator Yang, F
Yang, Y R
Wang, L
Huang, X H
Qiao, G
Zeng, Z L
description Residue depletion of marbofloxacin in broiler chicken after oral administration at 5 mg/kg/day for three consecutive days was studied in this study. The areas under the concentration-time curve from 0 h to ∞ (AUC0-∞ s) of marbofloxacin in tissues and plasma were used to calculate tissue/plasma partition coefficients (PX s). Based on PX s and the other parameters derived from published studies, a flow-limited physiologically based pharmacokinetics (PBPK) model was developed to predict marbofloxacin concentrations, which were then compared with those derived from the residue depletion study so as to validate this model. Considering individual difference in drug disposition, a Monte Carlo simulation included 1000 iterations was further incorporated into the validated model to generate a population PBPK model and to estimate the marbofloxacin residue withdrawal times in edible tissues. The withdrawal periods were compared to those derived from linear regression analysis. The PBPK model presented here successfully predicted the measured concentrations in all tissues. The withdrawal times in all edible tissues derived from the population PBPK model were longer than those from linear regression analysis, and based on the residues in kidney, a withdrawal time of 4 days was estimated for marbofloxacin after oral administration at 5 mg/kg/day for three consecutive days. It was shown that population PBPK model could be used to accurately predict marbofloxacin residue withdrawal time in edible tissues in broiler chickens.
doi_str_mv 10.1111/jvp.12137
format Article
fullrecord <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_24903645</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>24903645</sourcerecordid><originalsourceid>FETCH-LOGICAL-c148t-5bf2e8d446e7fa89404037d93e396e6b5c98a19a4061fa21bc14a13673c465933</originalsourceid><addsrcrecordid>eNo1UFFLwzAYDIK4OX3wD0j-QGfSpGnyKGM6YeCLPo8vabplS5uSdM6BP96Iei8Hx93BHUJ3lMxpxsP-Y5jTkrL6Ak0pE1VRSllN0HVKe0IIk5ReoUnJFWGCV1P0tUyj62B0_RZ3EHVoffgE43p8cuOuiXACj7PD4izpGJy3EZudMwfbJ3xMPznAQxiOPpeEHg-7c3LBh60z4P0Za0i2ySrEDkw4uN6OziTchcb6G3TZgk_29o9n6P1p-bZYFevX55fF47owlMuxqHRbWtlwLmzdglSccMLqRjHLlLBCV0ZJoAo4EbSFkuocg7y9ZoaLSjE2Q_e_vcNRd7bZDDFPjufN_w3sG2CXX6E</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Yang, F ; Yang, Y R ; Wang, L ; Huang, X H ; Qiao, G ; Zeng, Z L</creator><creatorcontrib>Yang, F ; Yang, Y R ; Wang, L ; Huang, X H ; Qiao, G ; Zeng, Z L</creatorcontrib><description>Residue depletion of marbofloxacin in broiler chicken after oral administration at 5 mg/kg/day for three consecutive days was studied in this study. The areas under the concentration-time curve from 0 h to ∞ (AUC0-∞ s) of marbofloxacin in tissues and plasma were used to calculate tissue/plasma partition coefficients (PX s). Based on PX s and the other parameters derived from published studies, a flow-limited physiologically based pharmacokinetics (PBPK) model was developed to predict marbofloxacin concentrations, which were then compared with those derived from the residue depletion study so as to validate this model. Considering individual difference in drug disposition, a Monte Carlo simulation included 1000 iterations was further incorporated into the validated model to generate a population PBPK model and to estimate the marbofloxacin residue withdrawal times in edible tissues. The withdrawal periods were compared to those derived from linear regression analysis. The PBPK model presented here successfully predicted the measured concentrations in all tissues. The withdrawal times in all edible tissues derived from the population PBPK model were longer than those from linear regression analysis, and based on the residues in kidney, a withdrawal time of 4 days was estimated for marbofloxacin after oral administration at 5 mg/kg/day for three consecutive days. It was shown that population PBPK model could be used to accurately predict marbofloxacin residue withdrawal time in edible tissues in broiler chickens.</description><identifier>EISSN: 1365-2885</identifier><identifier>DOI: 10.1111/jvp.12137</identifier><identifier>PMID: 24903645</identifier><language>eng</language><publisher>England</publisher><subject>Administration, Oral ; Animals ; Anti-Bacterial Agents - administration &amp; dosage ; Anti-Bacterial Agents - analysis ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - pharmacokinetics ; Chickens - metabolism ; Fluoroquinolones - administration &amp; dosage ; Fluoroquinolones - analysis ; Fluoroquinolones - blood ; Fluoroquinolones - pharmacokinetics ; Models, Biological ; Monte Carlo Method ; Tissue Distribution</subject><ispartof>Journal of veterinary pharmacology and therapeutics, 2014-12, Vol.37 (6), p.579</ispartof><rights>2014 John Wiley &amp; Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c148t-5bf2e8d446e7fa89404037d93e396e6b5c98a19a4061fa21bc14a13673c465933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24903645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, F</creatorcontrib><creatorcontrib>Yang, Y R</creatorcontrib><creatorcontrib>Wang, L</creatorcontrib><creatorcontrib>Huang, X H</creatorcontrib><creatorcontrib>Qiao, G</creatorcontrib><creatorcontrib>Zeng, Z L</creatorcontrib><title>Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model</title><title>Journal of veterinary pharmacology and therapeutics</title><addtitle>J Vet Pharmacol Ther</addtitle><description>Residue depletion of marbofloxacin in broiler chicken after oral administration at 5 mg/kg/day for three consecutive days was studied in this study. The areas under the concentration-time curve from 0 h to ∞ (AUC0-∞ s) of marbofloxacin in tissues and plasma were used to calculate tissue/plasma partition coefficients (PX s). Based on PX s and the other parameters derived from published studies, a flow-limited physiologically based pharmacokinetics (PBPK) model was developed to predict marbofloxacin concentrations, which were then compared with those derived from the residue depletion study so as to validate this model. Considering individual difference in drug disposition, a Monte Carlo simulation included 1000 iterations was further incorporated into the validated model to generate a population PBPK model and to estimate the marbofloxacin residue withdrawal times in edible tissues. The withdrawal periods were compared to those derived from linear regression analysis. The PBPK model presented here successfully predicted the measured concentrations in all tissues. The withdrawal times in all edible tissues derived from the population PBPK model were longer than those from linear regression analysis, and based on the residues in kidney, a withdrawal time of 4 days was estimated for marbofloxacin after oral administration at 5 mg/kg/day for three consecutive days. It was shown that population PBPK model could be used to accurately predict marbofloxacin residue withdrawal time in edible tissues in broiler chickens.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - administration &amp; dosage</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Chickens - metabolism</subject><subject>Fluoroquinolones - administration &amp; dosage</subject><subject>Fluoroquinolones - analysis</subject><subject>Fluoroquinolones - blood</subject><subject>Fluoroquinolones - pharmacokinetics</subject><subject>Models, Biological</subject><subject>Monte Carlo Method</subject><subject>Tissue Distribution</subject><issn>1365-2885</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UFFLwzAYDIK4OX3wD0j-QGfSpGnyKGM6YeCLPo8vabplS5uSdM6BP96Iei8Hx93BHUJ3lMxpxsP-Y5jTkrL6Ak0pE1VRSllN0HVKe0IIk5ReoUnJFWGCV1P0tUyj62B0_RZ3EHVoffgE43p8cuOuiXACj7PD4izpGJy3EZudMwfbJ3xMPznAQxiOPpeEHg-7c3LBh60z4P0Za0i2ySrEDkw4uN6OziTchcb6G3TZgk_29o9n6P1p-bZYFevX55fF47owlMuxqHRbWtlwLmzdglSccMLqRjHLlLBCV0ZJoAo4EbSFkuocg7y9ZoaLSjE2Q_e_vcNRd7bZDDFPjufN_w3sG2CXX6E</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Yang, F</creator><creator>Yang, Y R</creator><creator>Wang, L</creator><creator>Huang, X H</creator><creator>Qiao, G</creator><creator>Zeng, Z L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201412</creationdate><title>Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model</title><author>Yang, F ; Yang, Y R ; Wang, L ; Huang, X H ; Qiao, G ; Zeng, Z L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c148t-5bf2e8d446e7fa89404037d93e396e6b5c98a19a4061fa21bc14a13673c465933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - administration &amp; dosage</topic><topic>Anti-Bacterial Agents - analysis</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Chickens - metabolism</topic><topic>Fluoroquinolones - administration &amp; dosage</topic><topic>Fluoroquinolones - analysis</topic><topic>Fluoroquinolones - blood</topic><topic>Fluoroquinolones - pharmacokinetics</topic><topic>Models, Biological</topic><topic>Monte Carlo Method</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, F</creatorcontrib><creatorcontrib>Yang, Y R</creatorcontrib><creatorcontrib>Wang, L</creatorcontrib><creatorcontrib>Huang, X H</creatorcontrib><creatorcontrib>Qiao, G</creatorcontrib><creatorcontrib>Zeng, Z L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of veterinary pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, F</au><au>Yang, Y R</au><au>Wang, L</au><au>Huang, X H</au><au>Qiao, G</au><au>Zeng, Z L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model</atitle><jtitle>Journal of veterinary pharmacology and therapeutics</jtitle><addtitle>J Vet Pharmacol Ther</addtitle><date>2014-12</date><risdate>2014</risdate><volume>37</volume><issue>6</issue><spage>579</spage><pages>579-</pages><eissn>1365-2885</eissn><abstract>Residue depletion of marbofloxacin in broiler chicken after oral administration at 5 mg/kg/day for three consecutive days was studied in this study. The areas under the concentration-time curve from 0 h to ∞ (AUC0-∞ s) of marbofloxacin in tissues and plasma were used to calculate tissue/plasma partition coefficients (PX s). Based on PX s and the other parameters derived from published studies, a flow-limited physiologically based pharmacokinetics (PBPK) model was developed to predict marbofloxacin concentrations, which were then compared with those derived from the residue depletion study so as to validate this model. Considering individual difference in drug disposition, a Monte Carlo simulation included 1000 iterations was further incorporated into the validated model to generate a population PBPK model and to estimate the marbofloxacin residue withdrawal times in edible tissues. The withdrawal periods were compared to those derived from linear regression analysis. The PBPK model presented here successfully predicted the measured concentrations in all tissues. The withdrawal times in all edible tissues derived from the population PBPK model were longer than those from linear regression analysis, and based on the residues in kidney, a withdrawal time of 4 days was estimated for marbofloxacin after oral administration at 5 mg/kg/day for three consecutive days. It was shown that population PBPK model could be used to accurately predict marbofloxacin residue withdrawal time in edible tissues in broiler chickens.</abstract><cop>England</cop><pmid>24903645</pmid><doi>10.1111/jvp.12137</doi></addata></record>
fulltext fulltext
identifier EISSN: 1365-2885
ispartof Journal of veterinary pharmacology and therapeutics, 2014-12, Vol.37 (6), p.579
issn 1365-2885
language eng
recordid cdi_pubmed_primary_24903645
source MEDLINE; Access via Wiley Online Library
subjects Administration, Oral
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Chickens - metabolism
Fluoroquinolones - administration & dosage
Fluoroquinolones - analysis
Fluoroquinolones - blood
Fluoroquinolones - pharmacokinetics
Models, Biological
Monte Carlo Method
Tissue Distribution
title Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T19%3A04%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Estimating%20marbofloxacin%20withdrawal%20time%20in%20broiler%20chickens%20using%20a%20population%20physiologically%20based%20pharmacokinetics%20model&rft.jtitle=Journal%20of%20veterinary%20pharmacology%20and%20therapeutics&rft.au=Yang,%20F&rft.date=2014-12&rft.volume=37&rft.issue=6&rft.spage=579&rft.pages=579-&rft.eissn=1365-2885&rft_id=info:doi/10.1111/jvp.12137&rft_dat=%3Cpubmed%3E24903645%3C/pubmed%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/24903645&rfr_iscdi=true