Phosphate Binding Reduces Aortic Angiotensin-Converting Enzyme and Enhances Nitric Oxide Bioactivity in Experimental Renal Insufficiency

Background: Disturbed calcium-phosphorus metabolism is associated with increased kidney angiotensin-converting enzyme (ACE) in experimental chronic renal insufficiency (CRI). However, information about the effects of phosphate binding and loading on vascular ACE is lacking. Methods: Fifteen weeks af...

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Veröffentlicht in:	American journal of nephrology 2014-01, Vol.39 (5), p.400-408
Hauptverfasser:	Eräranta, Arttu, Törmänen, Suvi, Kööbi, Peeter, Vehmas, Tuija I., Lakkisto, Päivi, Tikkanen, Ilkka, Moilanen, Eeva, Niemelä, Onni, Mustonen, Jukka, Pörsti, Ilkka
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Aorta - enzymology Aortic Diseases Blood Pressure Calcinosis Calcium Carbonate - administration & dosage Endothelium - physiopathology Mesenteric Arteries - physiology Nephrectomy Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Nitric Oxide Synthase Type III - antagonists & inhibitors Nitric Oxide Synthase Type III - metabolism Norepinephrine - pharmacology Original Report: Laboratory Investigation Oxidative Stress Parathyroid Hormone - blood Peptidyl-Dipeptidase A - metabolism Phosphates - administration & dosage Phosphates - blood Rats Renal Insufficiency, Chronic - metabolism Vasoconstriction - drug effects Vasodilation - drug effects
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