Discrimination of heterogenous mRNAs encoding strychnine-sensitive glycine receptors in Xenopus oocytes by antisense oligonucleotides

Three synthetic oligodeoxynucleotides complementary to different parts of an RNA encoding a glycine receptor subunit were used to discriminate heterogenous mRNAs coding for glycine receptors in adult and neonatal rat spinal cord. Injection of the three antisense oligonucleotides into Xenopus oocytes...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-10, Vol.86 (20), p.8103-8107
Hauptverfasser:	Akagi, H, Patton, D E, Miledi, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Base Sequence beta-Alanine - pharmacology Female gamma-Aminobutyric Acid - pharmacology Glycine - pharmacology Glycine - physiology Kainic Acid - pharmacology Membrane Potentials - drug effects Molecular Sequence Data Oligonucleotide Probes Oocytes - drug effects Oocytes - physiology Poly A - genetics Poly A - isolation & purification Protein Biosynthesis Rats Receptors, Glycine Receptors, Neurotransmitter - genetics Receptors, Neurotransmitter - physiology RNA - genetics RNA, Antisense RNA, Messenger - antagonists & inhibitors RNA, Messenger - genetics RNA, Messenger - isolation & purification Serotonin - pharmacology Spinal Cord - growth & development Strychnine - pharmacology Xenopus
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