Biologically-active laminin-111 fragment that modulates the epithelial-to-mesenchymal transition in embryonic stem cells

The dynamic interplay between the extracellular matrix and embryonic stem cells (ESCs) constitutes one of the key steps in understanding stem cell differentiation in vitro. Here we report a biologically-active laminin-111 fragment generated by matrix metalloproteinase 2 (MMP2) processing, which is h...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-04, Vol.111 (16), p.5908-5913
Hauptverfasser:	Horejs, Christine-Maria, Serio, Andrea, Purvis, Alan, Gormley, Adam J., Bertazzo, Sergio, Poliniewicz, Anna, Wang, Alex J., DiMaggio, Peter, Hohenester, Erhard, Stevens, Molly M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basement membrane Basigin - metabolism Binding Sites Biological Sciences Cadherins Cadherins - metabolism Cell Adhesion cell differentiation Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryos Epithelial cells Epithelial-Mesenchymal Transition - genetics extracellular matrix gelatinase A Gene expression Gene Expression Regulation Humans Integrin alpha3beta1 - metabolism Integrins laminin Laminin - metabolism Matrix Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Membranes Mesenchymal stem cells Mice Peptide Fragments - metabolism Physiological regulation Pluripotent stem cells Protein Binding Proteins Signal Transduction Stem cells Tissue Inhibitor of Metalloproteinase-1 - metabolism Tissue Inhibitor of Metalloproteinase-2 - metabolism Up regulation
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