Antibacterial activity of a series of N2,N4-disubstituted quinazoline-2,4-diamines

A series of N(2),N(4)-disubstituted quinazoline-2,4-diamines has been synthesized and tested against multidrug resistant Staphylococcus aureus. A structure-activity and structure-property relationship study was conducted to identify new hit compounds. This study led to the identification of N(2),N(4...

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Veröffentlicht in:	Journal of medicinal chemistry 2014-04, Vol.57 (7), p.3075
Hauptverfasser:	Van Horn, Kurt S, Burda, Whittney N, Fleeman, Renee, Shaw, Lindsey N, Manetsch, Roman
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Diamines - chemistry Diamines - pharmacology Disease Models, Animal Hemolysis - drug effects Humans Larva - growth & development Larva - microbiology Microbial Sensitivity Tests Molecular Structure Peritonitis - drug therapy Peritonitis - microbiology Quinazolines - chemistry Quinazolines - pharmacology Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus - drug effects Structure-Activity Relationship
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