Unusual Calcium-Activated Potassium Channels of Bovine Parathyroid Cells
Parathyroid cells have unusual responses to an increase in the external calcium concentration--a reduction in secretion and a depolarization. In an attempt to explain this behavior, we have studied voltage-clamped inside-out patches from bovine parathyroid cells. We found a potassium-selective chann...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1988-10, Vol.85 (19), p.7236-7239 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Jia, Min Ehrenstein, Gerald Iwasa, Kunihiko |
| description | Parathyroid cells have unusual responses to an increase in the external calcium concentration--a reduction in secretion and a depolarization. In an attempt to explain this behavior, we have studied voltage-clamped inside-out patches from bovine parathyroid cells. We found a potassium-selective channel that requires internal calcium to open and has a 175-pS conductance. This channel differs from calcium-activated potassium channels that have been found in other cells in that it closes when the internal calcium concentration is increased above about 160 nM. This channel can account for the depolarization that occurs in parathyroid cells in high-calcium solutions. It may also account for the reduced secretion in high-calcium solutions. |
| doi_str_mv | 10.1073/pnas.85.19.7236 |
| format | Article |
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In an attempt to explain this behavior, we have studied voltage-clamped inside-out patches from bovine parathyroid cells. We found a potassium-selective channel that requires internal calcium to open and has a 175-pS conductance. This channel differs from calcium-activated potassium channels that have been found in other cells in that it closes when the internal calcium concentration is increased above about 160 nM. This channel can account for the depolarization that occurs in parathyroid cells in high-calcium solutions. It may also account for the reduced secretion in high-calcium solutions.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.85.19.7236</identifier><identifier>PMID: 2459700</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Acinar cells ; Animals ; Biological and medical sciences ; Calcium ; Calcium - metabolism ; Calcium activated potassium channels ; Cattle ; Cell physiology ; Depolarization ; Electric Conductivity ; Fundamental and applied biological sciences. Psychology ; Ion Channels - metabolism ; Membrane and intracellular transports ; Membrane potential ; Membrane Potentials ; Molecular and cellular biology ; Neurons ; parathyroid ; Parathyroid Glands - metabolism ; Pipettes ; Potassium ; Potassium - metabolism ; Secretion ; Ungulates</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1988-10, Vol.85 (19), p.7236-7239</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-64b72854404d607e13de77f6809de0ca775bdd357bb5cd5caacbe7b7994138cf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/85/19.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/32105$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/32105$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7223233$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2459700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Min</creatorcontrib><creatorcontrib>Ehrenstein, Gerald</creatorcontrib><creatorcontrib>Iwasa, Kunihiko</creatorcontrib><title>Unusual Calcium-Activated Potassium Channels of Bovine Parathyroid Cells</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Parathyroid cells have unusual responses to an increase in the external calcium concentration--a reduction in secretion and a depolarization. In an attempt to explain this behavior, we have studied voltage-clamped inside-out patches from bovine parathyroid cells. We found a potassium-selective channel that requires internal calcium to open and has a 175-pS conductance. This channel differs from calcium-activated potassium channels that have been found in other cells in that it closes when the internal calcium concentration is increased above about 160 nM. This channel can account for the depolarization that occurs in parathyroid cells in high-calcium solutions. It may also account for the reduced secretion in high-calcium solutions.</description><subject>Acinar cells</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium activated potassium channels</subject><subject>Cattle</subject><subject>Cell physiology</subject><subject>Depolarization</subject><subject>Electric Conductivity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ion Channels - metabolism</subject><subject>Membrane and intracellular transports</subject><subject>Membrane potential</subject><subject>Membrane Potentials</subject><subject>Molecular and cellular biology</subject><subject>Neurons</subject><subject>parathyroid</subject><subject>Parathyroid Glands - metabolism</subject><subject>Pipettes</subject><subject>Potassium</subject><subject>Potassium - metabolism</subject><subject>Secretion</subject><subject>Ungulates</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M9rFDEUB_AgSl2rZ0FQ5iB6mu3Lr8nkWAe1QsEe7Dm8STJ0SnZmTTLF_vdm2XG96SmQ7ycvjy8hrylsKSh-sZ8wbVu5pXqrGG-ekA0FTetGaHhKNgBM1a1g4jl5kdI9AGjZwhk5Y0JqBbAhV7fTkhYMVYfBjsuuvrR5fMDsXXUzZ0yp3FXdHU6TD6mah-rT_DBOvrrBiPnuMc6jqzofQnpJng0Ykn-1nufk9svnH91Vff3967fu8rq2kvNcFusVa6UQIFwDylPuvFJD04J2HiwqJXvnuFR9L62TFtH2XvVKa0F5awd-Tj4c5-7j_HPxKZvdmGzZACc_L8moVjSMMfgvpBIEMK0LvDhCG-eUoh_MPo47jI-GgjmUbA4lm1Yaqs2h5PLi7Tp66Xfenfzaasnfrzkmi2GIONkxnZhijDPOC_u4ssP8P-nff8ywhJD9r1zku3_KAt4cwX3KczwJzihI_hsBP6Vu</recordid><startdate>19881001</startdate><enddate>19881001</enddate><creator>Jia, Min</creator><creator>Ehrenstein, Gerald</creator><creator>Iwasa, Kunihiko</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19881001</creationdate><title>Unusual Calcium-Activated Potassium Channels of Bovine Parathyroid Cells</title><author>Jia, Min ; Ehrenstein, Gerald ; Iwasa, Kunihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-64b72854404d607e13de77f6809de0ca775bdd357bb5cd5caacbe7b7994138cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acinar cells</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Calcium activated potassium channels</topic><topic>Cattle</topic><topic>Cell physiology</topic><topic>Depolarization</topic><topic>Electric Conductivity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ion Channels - metabolism</topic><topic>Membrane and intracellular transports</topic><topic>Membrane potential</topic><topic>Membrane Potentials</topic><topic>Molecular and cellular biology</topic><topic>Neurons</topic><topic>parathyroid</topic><topic>Parathyroid Glands - metabolism</topic><topic>Pipettes</topic><topic>Potassium</topic><topic>Potassium - metabolism</topic><topic>Secretion</topic><topic>Ungulates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Min</creatorcontrib><creatorcontrib>Ehrenstein, Gerald</creatorcontrib><creatorcontrib>Iwasa, Kunihiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Min</au><au>Ehrenstein, Gerald</au><au>Iwasa, Kunihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unusual Calcium-Activated Potassium Channels of Bovine Parathyroid Cells</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1988-10-01</date><risdate>1988</risdate><volume>85</volume><issue>19</issue><spage>7236</spage><epage>7239</epage><pages>7236-7239</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Parathyroid cells have unusual responses to an increase in the external calcium concentration--a reduction in secretion and a depolarization. In an attempt to explain this behavior, we have studied voltage-clamped inside-out patches from bovine parathyroid cells. We found a potassium-selective channel that requires internal calcium to open and has a 175-pS conductance. This channel differs from calcium-activated potassium channels that have been found in other cells in that it closes when the internal calcium concentration is increased above about 160 nM. This channel can account for the depolarization that occurs in parathyroid cells in high-calcium solutions. It may also account for the reduced secretion in high-calcium solutions.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2459700</pmid><doi>10.1073/pnas.85.19.7236</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1988-10, Vol.85 (19), p.7236-7239 |
| issn | 0027-8424 1091-6490 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Acinar cells Animals Biological and medical sciences Calcium Calcium - metabolism Calcium activated potassium channels Cattle Cell physiology Depolarization Electric Conductivity Fundamental and applied biological sciences. Psychology Ion Channels - metabolism Membrane and intracellular transports Membrane potential Membrane Potentials Molecular and cellular biology Neurons parathyroid Parathyroid Glands - metabolism Pipettes Potassium Potassium - metabolism Secretion Ungulates |
| title | Unusual Calcium-Activated Potassium Channels of Bovine Parathyroid Cells |
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