Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure
Abstract Objectives: We aimed to evaluate oxidative stress [8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA)] endothelial damage [asymmetric dimethylarginine (ADMA)] and markers of cellular inflammation [interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), neopterin (NP) and high-sensit...
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| Veröffentlicht in: | Renal failure 2014-06, Vol.36 (5), p.767-773 |
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| creator | Avci, Emre Çakir, Erdinc Cevher, Sule Coskun Yaman, Halil Agilli, Mehmet Bilgi, Cumhur |
| description | Abstract
Objectives: We aimed to evaluate oxidative stress [8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA)] endothelial damage [asymmetric dimethylarginine (ADMA)] and markers of cellular inflammation [interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), neopterin (NP) and high-sensitivity C-reactive protein (hsCRP)] in patients with diabetic nephropathy (DN) and non-diabetic nephropathy who were being administered hemodialysis treatment because of chronic renal failure. Methods: In determining 8-OHdG, IL-6 and TNF-α levels, Enzyme-Linked Immuno-Sorbent Assay method was used. Serum MDA, ADMA and NP levels were determined by using high performance liquid chromatography (HPLC). And hs-CRP values were measured with nephelometric method. Results: Serum 8-OHdG and MDA levels were found statistically to have increased when compared with those of the control group in patients groups after dialysis. However, serum ADMA and neopterin levels were observed statistically to have decreased when compared with those of the control group in patients groups after dialysis. But, decreases on ADMA and neopterin levels are still much higher than those of control. IL-6 and TNF-α levels were found to have increased when compared with those of control group in patients groups before dialysis. Conclusion: The oxidative stress in patients with DN, who were being treated with hemodialysis due to chronic renal failure, was higher than that of non-DN patients who were being treated with hemodialysis. In contrast with this, inflammation occurring in non-DN patients was found to have been higher than that of in patients with DN. |
| doi_str_mv | 10.3109/0886022X.2014.890841 |
| format | Article |
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Objectives: We aimed to evaluate oxidative stress [8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA)] endothelial damage [asymmetric dimethylarginine (ADMA)] and markers of cellular inflammation [interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), neopterin (NP) and high-sensitivity C-reactive protein (hsCRP)] in patients with diabetic nephropathy (DN) and non-diabetic nephropathy who were being administered hemodialysis treatment because of chronic renal failure. Methods: In determining 8-OHdG, IL-6 and TNF-α levels, Enzyme-Linked Immuno-Sorbent Assay method was used. Serum MDA, ADMA and NP levels were determined by using high performance liquid chromatography (HPLC). And hs-CRP values were measured with nephelometric method. Results: Serum 8-OHdG and MDA levels were found statistically to have increased when compared with those of the control group in patients groups after dialysis. However, serum ADMA and neopterin levels were observed statistically to have decreased when compared with those of the control group in patients groups after dialysis. But, decreases on ADMA and neopterin levels are still much higher than those of control. IL-6 and TNF-α levels were found to have increased when compared with those of control group in patients groups before dialysis. Conclusion: The oxidative stress in patients with DN, who were being treated with hemodialysis due to chronic renal failure, was higher than that of non-DN patients who were being treated with hemodialysis. In contrast with this, inflammation occurring in non-DN patients was found to have been higher than that of in patients with DN.</description><identifier>ISSN: 0886-022X</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.3109/0886022X.2014.890841</identifier><identifier>PMID: 24579657</identifier><language>eng</language><publisher>England: Informa Healthcare USA, Inc</publisher><subject>Aged ; Arginine - analogs & derivatives ; Arginine - blood ; Biomarkers - blood ; C-Reactive Protein - metabolism ; Case-Control Studies ; Cellular inflammation ; chronic renal failure ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - blood ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - complications ; diabetic nephropathy ; Female ; hemodialysis ; Humans ; Inflammation - blood ; Inflammation - etiology ; Interleukin-6 - blood ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Male ; Malondialdehyde - blood ; Middle Aged ; Neopterin - blood ; Oxidative Stress ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Renal failure, 2014-06, Vol.36 (5), p.767-773</ispartof><rights>2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-8d94b0c9ab009d263715af93e943b1e08ef17447f22a7d8c88f8bd5e82393e463</citedby><cites>FETCH-LOGICAL-c464t-8d94b0c9ab009d263715af93e943b1e08ef17447f22a7d8c88f8bd5e82393e463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24579657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avci, Emre</creatorcontrib><creatorcontrib>Çakir, Erdinc</creatorcontrib><creatorcontrib>Cevher, Sule Coskun</creatorcontrib><creatorcontrib>Yaman, Halil</creatorcontrib><creatorcontrib>Agilli, Mehmet</creatorcontrib><creatorcontrib>Bilgi, Cumhur</creatorcontrib><title>Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description>Abstract
Objectives: We aimed to evaluate oxidative stress [8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA)] endothelial damage [asymmetric dimethylarginine (ADMA)] and markers of cellular inflammation [interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), neopterin (NP) and high-sensitivity C-reactive protein (hsCRP)] in patients with diabetic nephropathy (DN) and non-diabetic nephropathy who were being administered hemodialysis treatment because of chronic renal failure. Methods: In determining 8-OHdG, IL-6 and TNF-α levels, Enzyme-Linked Immuno-Sorbent Assay method was used. Serum MDA, ADMA and NP levels were determined by using high performance liquid chromatography (HPLC). And hs-CRP values were measured with nephelometric method. Results: Serum 8-OHdG and MDA levels were found statistically to have increased when compared with those of the control group in patients groups after dialysis. However, serum ADMA and neopterin levels were observed statistically to have decreased when compared with those of the control group in patients groups after dialysis. But, decreases on ADMA and neopterin levels are still much higher than those of control. IL-6 and TNF-α levels were found to have increased when compared with those of control group in patients groups before dialysis. Conclusion: The oxidative stress in patients with DN, who were being treated with hemodialysis due to chronic renal failure, was higher than that of non-DN patients who were being treated with hemodialysis. In contrast with this, inflammation occurring in non-DN patients was found to have been higher than that of in patients with DN.</description><subject>Aged</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - blood</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Cellular inflammation</subject><subject>chronic renal failure</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - blood</subject><subject>Diabetic Nephropathies - blood</subject><subject>Diabetic Nephropathies - complications</subject><subject>diabetic nephropathy</subject><subject>Female</subject><subject>hemodialysis</subject><subject>Humans</subject><subject>Inflammation - blood</subject><subject>Inflammation - etiology</subject><subject>Interleukin-6 - blood</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>Neopterin - blood</subject><subject>Oxidative Stress</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0886-022X</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-L1TAUxYsoznP0G4hk6abPJE3bdKPI-BcG3Ci4C7fNjc2QJs8kdXwf0O9l6psRBJlVEvI75x7uqaqnjO4bRocXVMqOcv51zykTezlQKdi9asda3tYdFcP9arch9cacVY9SuqKUtbLnD6szLtp-6Np-V_16gxnjYj1kGzwJhoSfVpfHDyQpR0yJgNdkQudWB5FYbxwsy4m2nhzKDX1O5NrmmWgLI2Y7EY-HOYbyOR__6H3w9X8_R7T-GwFdEthUkqAmMy6hsO6YbCIlAuSlTCB6RZIDmYrUF5OIHhwxYN0a8XH1wIBL-OTmPK--vHv7-eJDffnp_ceL15f1JDqRa6kHMdJpgJHSQfOu6VkLZmhwEM3IkEo0rBeiN5xDr-UkpZGjblHypkCia86r5yffQwzfV0xZLTZtuwGPYU2KtQ1teNl4U1BxQqcYUopo1CHaBeJRMaq2AtVtgWorUJ0KLLJnNxPWcUH9V3TbWAFenYDSRIgLXIfotMpwdCGaCH6yabO_c8TLfxxmBJfnCSKqq7DGstZ0d8bftiPEkQ</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Avci, Emre</creator><creator>Çakir, Erdinc</creator><creator>Cevher, Sule Coskun</creator><creator>Yaman, Halil</creator><creator>Agilli, Mehmet</creator><creator>Bilgi, Cumhur</creator><general>Informa Healthcare USA, Inc</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure</title><author>Avci, Emre ; Çakir, Erdinc ; Cevher, Sule Coskun ; Yaman, Halil ; Agilli, Mehmet ; Bilgi, Cumhur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-8d94b0c9ab009d263715af93e943b1e08ef17447f22a7d8c88f8bd5e82393e463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - blood</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>Cellular inflammation</topic><topic>chronic renal failure</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - blood</topic><topic>Diabetic Nephropathies - blood</topic><topic>Diabetic Nephropathies - complications</topic><topic>diabetic nephropathy</topic><topic>Female</topic><topic>hemodialysis</topic><topic>Humans</topic><topic>Inflammation - blood</topic><topic>Inflammation - etiology</topic><topic>Interleukin-6 - blood</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>Neopterin - blood</topic><topic>Oxidative Stress</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avci, Emre</creatorcontrib><creatorcontrib>Çakir, Erdinc</creatorcontrib><creatorcontrib>Cevher, Sule Coskun</creatorcontrib><creatorcontrib>Yaman, Halil</creatorcontrib><creatorcontrib>Agilli, Mehmet</creatorcontrib><creatorcontrib>Bilgi, Cumhur</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avci, Emre</au><au>Çakir, Erdinc</au><au>Cevher, Sule Coskun</au><au>Yaman, Halil</au><au>Agilli, Mehmet</au><au>Bilgi, Cumhur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>36</volume><issue>5</issue><spage>767</spage><epage>773</epage><pages>767-773</pages><issn>0886-022X</issn><eissn>1525-6049</eissn><abstract>Abstract
Objectives: We aimed to evaluate oxidative stress [8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA)] endothelial damage [asymmetric dimethylarginine (ADMA)] and markers of cellular inflammation [interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), neopterin (NP) and high-sensitivity C-reactive protein (hsCRP)] in patients with diabetic nephropathy (DN) and non-diabetic nephropathy who were being administered hemodialysis treatment because of chronic renal failure. Methods: In determining 8-OHdG, IL-6 and TNF-α levels, Enzyme-Linked Immuno-Sorbent Assay method was used. Serum MDA, ADMA and NP levels were determined by using high performance liquid chromatography (HPLC). And hs-CRP values were measured with nephelometric method. Results: Serum 8-OHdG and MDA levels were found statistically to have increased when compared with those of the control group in patients groups after dialysis. However, serum ADMA and neopterin levels were observed statistically to have decreased when compared with those of the control group in patients groups after dialysis. But, decreases on ADMA and neopterin levels are still much higher than those of control. IL-6 and TNF-α levels were found to have increased when compared with those of control group in patients groups before dialysis. Conclusion: The oxidative stress in patients with DN, who were being treated with hemodialysis due to chronic renal failure, was higher than that of non-DN patients who were being treated with hemodialysis. In contrast with this, inflammation occurring in non-DN patients was found to have been higher than that of in patients with DN.</abstract><cop>England</cop><pub>Informa Healthcare USA, Inc</pub><pmid>24579657</pmid><doi>10.3109/0886022X.2014.890841</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Arginine - analogs & derivatives Arginine - blood Biomarkers - blood C-Reactive Protein - metabolism Case-Control Studies Cellular inflammation chronic renal failure Deoxyguanosine - analogs & derivatives Deoxyguanosine - blood Diabetic Nephropathies - blood Diabetic Nephropathies - complications diabetic nephropathy Female hemodialysis Humans Inflammation - blood Inflammation - etiology Interleukin-6 - blood Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Male Malondialdehyde - blood Middle Aged Neopterin - blood Oxidative Stress Tumor Necrosis Factor-alpha - blood |
| title | Determination of oxidative stress and cellular inflammation in patients with diabetic nephropathy and non-diabetic nephropathy being administered hemodialysis treatment due to chronic renal failure |
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