Induction of Phagocytosis and Intracellular Signaling by an Inhibitory Channel Catfish Leukocyte Immune-Type Receptor: Evidence for Immunoregulatory Receptor Functional Plasticity in Teleosts

Immunoregulatory receptors are categorized as stimulatory or inhibitory based on their engagement of unique intracellular signaling networks. These proteins also display functional plasticity, which adds versatility to the control of innate immunity. Here we demonstrate that an inhibitory catfish le...

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Veröffentlicht in:	Journal of innate immunity 2014-01, Vol.6 (4), p.435-455
Hauptverfasser:	Cortes, Herman D., Lillico, Dustin M.E., Zwozdesky, Myron A., Pemberton, Joshua G., O'Brien, Allen, Montgomery, Benjamin C.S., Wiersma, Loes, Chang, John P., Stafford, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cytochalasin D - pharmacology Cytokines - metabolism Edetic Acid - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism Ictaluridae Ictalurus punctatus Immunity, Innate Immunomodulation - drug effects Immunomodulation - genetics Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Myeloid Cells - drug effects Myeloid Cells - immunology Phagocytosis - genetics Protein Engineering Protein Structure, Tertiary - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Research Article Sequence Deletion - genetics Signal Transduction - drug effects Signal Transduction - genetics Teleostei Transgenes - genetics
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