Low prevalence of positive interferon-gamma tests in HIV-positive long-term immigrants in Norway
OBJECTIVE: To determine the prevalence and predictors of positive interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs) in human immunodeficiency virus (HIV) infected patients in Norway, a low tuberculosis (TB) endemic country.DESIGN: Multicentre cross-sectional study of 298 HIV p...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2014-02, Vol.18 (2), p.180-187 |
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| container_title | The international journal of tuberculosis and lung disease |
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| creator | Pullar, N. D. Steinum, H. Tonby, K. Heggelund, L. Leiva, R. A. Ofstad, R. Bruun, J. N. Dyrhol-Riise, A. M. |
| description | OBJECTIVE: To determine the prevalence and predictors of positive interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs) in human immunodeficiency virus (HIV) infected patients in Norway, a low tuberculosis (TB) endemic country.DESIGN: Multicentre cross-sectional
study of 298 HIV patients tested with QuantiFERON®-TB Gold In-Tube (QFT-GIT), T-SPOT®.TB (T-SPOT) and TST.RESULTS: A total of 77/298 (26%) QFT-GIT, 29/117 (25%) T-SPOT and 52/217 (24%) TSTs (≥5 mm) were positive. The median CD4 count was 427 cells/l. Three QFT-GIT results
but no T-SPOT results were indeterminate. Of 52 TST-positive patients, 34 (65%) were QFT-GIT-positive (median interferon-gamma [IFN-] 4.38 international units [IU]/ml), compared to 16% of the TST-negative patients (median INF- 0.81 IU/ml, P < 0.001). Origin from a TB-endemic country,
previous active TB and TB exposure were associated with a positive QFT-GIT (P 0.01). Patients from TB-endemic countries living in Norway for ≥10 years had lower odds of a positive QFT-GIT (12%; OR 0.17, 95%CI 0.060.53, P 0.002) than patients with 03 years' residence (49%).CONCLUSION:
The prevalence of positive IGRAs in HIV-infected patients was high in this low TB endemic setting. Lower QFT-GIT positivity in long-term residents from TB-endemic countries may reflect a waning of TB-specific immune responses. |
| doi_str_mv | 10.5588/ijtld.13.0276 |
| format | Article |
| fullrecord | <record><control><sourceid>pubtec_pubme</sourceid><recordid>TN_cdi_pubmed_primary_24429310</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ingid>iuatld/ijtld/2014/00000018/00000002/art00010</ingid><sourcerecordid>iuatld/ijtld/2014/00000018/00000002/art00010</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-aba3245fd166cc7d84c2a1de0daa01efd274eeabfc2fc36809ca5d052820a1c73</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEoqVw5IpyQeKSxeOPjXNE5aOVViAk4GpmHXvlVWIvtrNV-fU4zbacEL54NHr0jv1oquolkJUQUr51-zz0K2ArQtv1o-ocJIim7Sh5XOrSa1gL3Vn1LKU9IRQA2qfVGeWcdgzIefVzE27qQzRHHIzXpg62PoTksjua2vlsojUx-GaH44h1Nimn0q6vrn80D9gQ_K4p5Fi7cXS7iH6BPod4g7fPqycWh2RenO6L6vvHD98ur5rNl0_Xl-82jeYd5Aa3yCgXtof1Wuu2l1xThN6QHpGAsT1tuTG4tZpazdaSdBpFTwSVlCDoll1Ub5bcQwy_pvJQNbqkzTCgN2FKCgTnBAgT5P8o70grBGWsoM2C6hhSisaqQ3QjxlsFRM3-1Z1_BUzN_gv_6hQ9bUfTP9D3wgvw-gRg0jjYYku79JeTFAo4f-f9wjm_Mz6j2ocp-iJQuQnnictcSoArcndAngpCFcY8d-ZxX_8Vo--T5i2Zl0QdQXpaIikQSUXRIKTqjcVpyCpjVLvfKpXMP5t3wM8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1490755233</pqid></control><display><type>article</type><title>Low prevalence of positive interferon-gamma tests in HIV-positive long-term immigrants in Norway</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Pullar, N. D. ; Steinum, H. ; Tonby, K. ; Heggelund, L. ; Leiva, R. A. ; Ofstad, R. ; Bruun, J. N. ; Dyrhol-Riise, A. M.</creator><creatorcontrib>Pullar, N. D. ; Steinum, H. ; Tonby, K. ; Heggelund, L. ; Leiva, R. A. ; Ofstad, R. ; Bruun, J. N. ; Dyrhol-Riise, A. M.</creatorcontrib><description>OBJECTIVE: To determine the prevalence and predictors of positive interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs) in human immunodeficiency virus (HIV) infected patients in Norway, a low tuberculosis (TB) endemic country.DESIGN: Multicentre cross-sectional
study of 298 HIV patients tested with QuantiFERON®-TB Gold In-Tube (QFT-GIT), T-SPOT®.TB (T-SPOT) and TST.RESULTS: A total of 77/298 (26%) QFT-GIT, 29/117 (25%) T-SPOT and 52/217 (24%) TSTs (≥5 mm) were positive. The median CD4 count was 427 cells/l. Three QFT-GIT results
but no T-SPOT results were indeterminate. Of 52 TST-positive patients, 34 (65%) were QFT-GIT-positive (median interferon-gamma [IFN-] 4.38 international units [IU]/ml), compared to 16% of the TST-negative patients (median INF- 0.81 IU/ml, P < 0.001). Origin from a TB-endemic country,
previous active TB and TB exposure were associated with a positive QFT-GIT (P 0.01). Patients from TB-endemic countries living in Norway for ≥10 years had lower odds of a positive QFT-GIT (12%; OR 0.17, 95%CI 0.060.53, P 0.002) than patients with 03 years' residence (49%).CONCLUSION:
The prevalence of positive IGRAs in HIV-infected patients was high in this low TB endemic setting. Lower QFT-GIT positivity in long-term residents from TB-endemic countries may reflect a waning of TB-specific immune responses.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>DOI: 10.5588/ijtld.13.0276</identifier><identifier>PMID: 24429310</identifier><language>eng</language><publisher>Paris, France: International Union Against Tuberculosis and Lung Disease</publisher><subject>Adult ; Aged ; Bacterial diseases ; Biological and medical sciences ; CD4 Lymphocyte Count ; Coinfection ; Cross-Sectional Studies ; Emigrants and Immigrants ; Emigration and Immigration ; Endemic Diseases ; Female ; HIV Infections - diagnosis ; HIV Infections - ethnology ; HIV Infections - immunology ; Human bacterial diseases ; Human immunodeficiency virus ; Human viral diseases ; Humans ; IGRA ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Interferon-gamma Release Tests - methods ; Low-Endemic Country ; Male ; Medical sciences ; Middle Aged ; Mycobacterium ; Norway - epidemiology ; Pneumology ; Predictive Value of Tests ; Prevalence ; Quantiferon ; Risk Factors ; Time Factors ; Tuberculin Skin Testing ; Tuberculin Test ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - ethnology ; Tuberculosis - immunology ; Tuberculosis - microbiology ; Tuberculosis and atypical mycobacterial infections ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult</subject><ispartof>The international journal of tuberculosis and lung disease, 2014-02, Vol.18 (2), p.180-187</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-aba3245fd166cc7d84c2a1de0daa01efd274eeabfc2fc36809ca5d052820a1c73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28212937$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24429310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pullar, N. D.</creatorcontrib><creatorcontrib>Steinum, H.</creatorcontrib><creatorcontrib>Tonby, K.</creatorcontrib><creatorcontrib>Heggelund, L.</creatorcontrib><creatorcontrib>Leiva, R. A.</creatorcontrib><creatorcontrib>Ofstad, R.</creatorcontrib><creatorcontrib>Bruun, J. N.</creatorcontrib><creatorcontrib>Dyrhol-Riise, A. M.</creatorcontrib><title>Low prevalence of positive interferon-gamma tests in HIV-positive long-term immigrants in Norway</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>OBJECTIVE: To determine the prevalence and predictors of positive interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs) in human immunodeficiency virus (HIV) infected patients in Norway, a low tuberculosis (TB) endemic country.DESIGN: Multicentre cross-sectional
study of 298 HIV patients tested with QuantiFERON®-TB Gold In-Tube (QFT-GIT), T-SPOT®.TB (T-SPOT) and TST.RESULTS: A total of 77/298 (26%) QFT-GIT, 29/117 (25%) T-SPOT and 52/217 (24%) TSTs (≥5 mm) were positive. The median CD4 count was 427 cells/l. Three QFT-GIT results
but no T-SPOT results were indeterminate. Of 52 TST-positive patients, 34 (65%) were QFT-GIT-positive (median interferon-gamma [IFN-] 4.38 international units [IU]/ml), compared to 16% of the TST-negative patients (median INF- 0.81 IU/ml, P < 0.001). Origin from a TB-endemic country,
previous active TB and TB exposure were associated with a positive QFT-GIT (P 0.01). Patients from TB-endemic countries living in Norway for ≥10 years had lower odds of a positive QFT-GIT (12%; OR 0.17, 95%CI 0.060.53, P 0.002) than patients with 03 years' residence (49%).CONCLUSION:
The prevalence of positive IGRAs in HIV-infected patients was high in this low TB endemic setting. Lower QFT-GIT positivity in long-term residents from TB-endemic countries may reflect a waning of TB-specific immune responses.</description><subject>Adult</subject><subject>Aged</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Coinfection</subject><subject>Cross-Sectional Studies</subject><subject>Emigrants and Immigrants</subject><subject>Emigration and Immigration</subject><subject>Endemic Diseases</subject><subject>Female</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - ethnology</subject><subject>HIV Infections - immunology</subject><subject>Human bacterial diseases</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>IGRA</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Interferon-gamma Release Tests - methods</subject><subject>Low-Endemic Country</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium</subject><subject>Norway - epidemiology</subject><subject>Pneumology</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Quantiferon</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Tuberculin Skin Testing</subject><subject>Tuberculin Test</subject><subject>Tuberculosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - ethnology</subject><subject>Tuberculosis - immunology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Young Adult</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEoqVw5IpyQeKSxeOPjXNE5aOVViAk4GpmHXvlVWIvtrNV-fU4zbacEL54NHr0jv1oquolkJUQUr51-zz0K2ArQtv1o-ocJIim7Sh5XOrSa1gL3Vn1LKU9IRQA2qfVGeWcdgzIefVzE27qQzRHHIzXpg62PoTksjua2vlsojUx-GaH44h1Nimn0q6vrn80D9gQ_K4p5Fi7cXS7iH6BPod4g7fPqycWh2RenO6L6vvHD98ur5rNl0_Xl-82jeYd5Aa3yCgXtof1Wuu2l1xThN6QHpGAsT1tuTG4tZpazdaSdBpFTwSVlCDoll1Ub5bcQwy_pvJQNbqkzTCgN2FKCgTnBAgT5P8o70grBGWsoM2C6hhSisaqQ3QjxlsFRM3-1Z1_BUzN_gv_6hQ9bUfTP9D3wgvw-gRg0jjYYku79JeTFAo4f-f9wjm_Mz6j2ocp-iJQuQnnictcSoArcndAngpCFcY8d-ZxX_8Vo--T5i2Zl0QdQXpaIikQSUXRIKTqjcVpyCpjVLvfKpXMP5t3wM8</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Pullar, N. D.</creator><creator>Steinum, H.</creator><creator>Tonby, K.</creator><creator>Heggelund, L.</creator><creator>Leiva, R. A.</creator><creator>Ofstad, R.</creator><creator>Bruun, J. N.</creator><creator>Dyrhol-Riise, A. M.</creator><general>International Union Against Tuberculosis and Lung Disease</general><general>International Union against Tuberculosis and Lung Disease</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20140201</creationdate><title>Low prevalence of positive interferon-gamma tests in HIV-positive long-term immigrants in Norway</title><author>Pullar, N. D. ; Steinum, H. ; Tonby, K. ; Heggelund, L. ; Leiva, R. A. ; Ofstad, R. ; Bruun, J. N. ; Dyrhol-Riise, A. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-aba3245fd166cc7d84c2a1de0daa01efd274eeabfc2fc36809ca5d052820a1c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>Coinfection</topic><topic>Cross-Sectional Studies</topic><topic>Emigrants and Immigrants</topic><topic>Emigration and Immigration</topic><topic>Endemic Diseases</topic><topic>Female</topic><topic>HIV Infections - diagnosis</topic><topic>HIV Infections - ethnology</topic><topic>HIV Infections - immunology</topic><topic>Human bacterial diseases</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>IGRA</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Interferon-gamma Release Tests - methods</topic><topic>Low-Endemic Country</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycobacterium</topic><topic>Norway - epidemiology</topic><topic>Pneumology</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Quantiferon</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Tuberculin Skin Testing</topic><topic>Tuberculin Test</topic><topic>Tuberculosis</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - ethnology</topic><topic>Tuberculosis - immunology</topic><topic>Tuberculosis - microbiology</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pullar, N. D.</creatorcontrib><creatorcontrib>Steinum, H.</creatorcontrib><creatorcontrib>Tonby, K.</creatorcontrib><creatorcontrib>Heggelund, L.</creatorcontrib><creatorcontrib>Leiva, R. A.</creatorcontrib><creatorcontrib>Ofstad, R.</creatorcontrib><creatorcontrib>Bruun, J. N.</creatorcontrib><creatorcontrib>Dyrhol-Riise, A. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pullar, N. D.</au><au>Steinum, H.</au><au>Tonby, K.</au><au>Heggelund, L.</au><au>Leiva, R. A.</au><au>Ofstad, R.</au><au>Bruun, J. N.</au><au>Dyrhol-Riise, A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low prevalence of positive interferon-gamma tests in HIV-positive long-term immigrants in Norway</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>18</volume><issue>2</issue><spage>180</spage><epage>187</epage><pages>180-187</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>OBJECTIVE: To determine the prevalence and predictors of positive interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs) in human immunodeficiency virus (HIV) infected patients in Norway, a low tuberculosis (TB) endemic country.DESIGN: Multicentre cross-sectional
study of 298 HIV patients tested with QuantiFERON®-TB Gold In-Tube (QFT-GIT), T-SPOT®.TB (T-SPOT) and TST.RESULTS: A total of 77/298 (26%) QFT-GIT, 29/117 (25%) T-SPOT and 52/217 (24%) TSTs (≥5 mm) were positive. The median CD4 count was 427 cells/l. Three QFT-GIT results
but no T-SPOT results were indeterminate. Of 52 TST-positive patients, 34 (65%) were QFT-GIT-positive (median interferon-gamma [IFN-] 4.38 international units [IU]/ml), compared to 16% of the TST-negative patients (median INF- 0.81 IU/ml, P < 0.001). Origin from a TB-endemic country,
previous active TB and TB exposure were associated with a positive QFT-GIT (P 0.01). Patients from TB-endemic countries living in Norway for ≥10 years had lower odds of a positive QFT-GIT (12%; OR 0.17, 95%CI 0.060.53, P 0.002) than patients with 03 years' residence (49%).CONCLUSION:
The prevalence of positive IGRAs in HIV-infected patients was high in this low TB endemic setting. Lower QFT-GIT positivity in long-term residents from TB-endemic countries may reflect a waning of TB-specific immune responses.</abstract><cop>Paris, France</cop><pub>International Union Against Tuberculosis and Lung Disease</pub><pmid>24429310</pmid><doi>10.5588/ijtld.13.0276</doi><tpages>8</tpages></addata></record> |
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| ispartof | The international journal of tuberculosis and lung disease, 2014-02, Vol.18 (2), p.180-187 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Bacterial diseases Biological and medical sciences CD4 Lymphocyte Count Coinfection Cross-Sectional Studies Emigrants and Immigrants Emigration and Immigration Endemic Diseases Female HIV Infections - diagnosis HIV Infections - ethnology HIV Infections - immunology Human bacterial diseases Human immunodeficiency virus Human viral diseases Humans IGRA Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Interferon-gamma Release Tests - methods Low-Endemic Country Male Medical sciences Middle Aged Mycobacterium Norway - epidemiology Pneumology Predictive Value of Tests Prevalence Quantiferon Risk Factors Time Factors Tuberculin Skin Testing Tuberculin Test Tuberculosis Tuberculosis - diagnosis Tuberculosis - ethnology Tuberculosis - immunology Tuberculosis - microbiology Tuberculosis and atypical mycobacterial infections Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult |
| title | Low prevalence of positive interferon-gamma tests in HIV-positive long-term immigrants in Norway |
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