Construction of a highly stable artificial glutathione peroxidase on a protein nanoring

Stable Protein One (SP1) is a boiling-stable oligomeric protein. The unique characteristics of SP1 offer a scaffold to design artificial enzymes against extreme temperature. Here, an efficient antioxidase is successfully constructed on the ring-shaped SP1 homododecamer. By means of computational des...

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Veröffentlicht in:	Organic & biomolecular chemistry 2014-01, Vol.12 (2), p.362-369
Hauptverfasser:	Miao, Lu, Zhang, Xiyu, Si, Chengye, Gao, Yuzhou, Zhao, Linlu, Hou, Chunxi, Shoseyov, Oded, Luo, Quan, Liu, Junqiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Genetic Engineering Glutathione Peroxidase - chemistry Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Kinetics Models, Molecular Mutagenesis, Site-Directed Nanostructures - chemistry Protein Stability Quantum Theory Selenocysteine - chemistry Selenocysteine - genetics Selenocysteine - metabolism Temperature
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