IL-17A Induces Pro-Inflammatory Cytokines Production in Macrophages via MAPKinases, NF-κB and AP-1

Background: Interleukin (IL)-17A, a newly identified cytokine, may participate in the transition of a stable plaque into an unstable plaque. Macrophages play a critical role in the destabilization of atherosclerotic plaque. Methods: RAW 264.7 cells were stimulated with IL-17A. The mRNA expression of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cellular physiology and biochemistry 2013-01, Vol.32 (5), p.1265-1274
Hauptverfasser:	Chen, Jian, Liao, Meng-yang, Gao, Xing-li, Zhong, Qi, Tang, Ting-ting, Yu, Xian, Liao, Yu-hua, Cheng, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cytokines - genetics Cytokines - metabolism Enzyme Inhibitors - pharmacology Inflammation - metabolism Inflammatory cytokines Interleukin 17A Interleukin-17 - metabolism Interleukin-17 - pharmacology Interleukin-1beta - genetics Interleukin-6 - genetics Macrophages Macrophages - drug effects Macrophages - metabolism Mice Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism Original Paper p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Receptors, Interleukin-17 - metabolism Transcription Factor AP-1 - metabolism Tumor Necrosis Factor-alpha - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!