Pharmacodynamic effects of standard dose prasugrel versus high dose clopidogrel in non-diabetic obese patients with coronary artery disease

Increased body weight is independently associated with impaired clopidogrel pharmacodynamic (PD) response. Prasugrel has more potent PD effects compared with clopidogrel, although its PD effects in obese patients are unknown. The aim of this prospective, randomised, study was to compare the PD effec...

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Veröffentlicht in:	Thrombosis and haemostasis 2014-02, Vol.111 (2), p.258-265
Hauptverfasser:	Darlington, Andrew, Tello-Montoliu, Antonio, Rollini, Fabiana, Ueno, Masafumi, Ferreiro, José Luis, Patel, Ronakkumar, Desai, Bhaloo, Guzman, Luis A., Bass, Theodore A., Angiolillo, Dominick
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspirin - administration & dosage Biological and medical sciences Biomarkers - blood Blood coagulation. Blood cells Blood Platelets - drug effects Blood Platelets - metabolism Body Mass Index Cell Adhesion Molecules - blood clopidogrel Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - complications Coronary Artery Disease - diagnosis Coronary Artery Disease - drug therapy Drug Therapy, Combination Female Florida Fundamental and applied biological sciences. Psychology Hematologic and hematopoietic diseases Humans Male Medical sciences Microfilament Proteins - blood Middle Aged Molecular and cellular biology obesity Obesity - complications Obesity - diagnosis Phosphoproteins - blood Phosphorylation Piperazines - administration & dosage Piperazines - adverse effects Platelet Activation - drug effects Platelet Adhesiveness - drug effects Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Platelet diseases and coagulopathies Platelet function Platelet Function Tests Platelets and Blood Cells prasugrel Prasugrel Hydrochloride Prospective Studies Receptors, Purinergic P2Y12 - blood Receptors, Purinergic P2Y12 - drug effects Thiophenes - administration & dosage Thiophenes - adverse effects Ticlopidine - administration & dosage Ticlopidine - adverse effects Ticlopidine - analogs & derivatives Time Factors Treatment Outcome
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