Relationship between Changes in Plasma Leptin Concentrations and Plasminogen Activator Inhibitor-1 in Obese Prepubertal Children after Nine Months of Treatment
Background/Aims: The metabolic syndrome (MS) is associated with insulin resistance (IR), inappropriate fibrinolysis and high plasma leptin concentrations. The aim of this study was to quantify fibrinolysis and MS-related variables in obese prepubertal children and to evaluate changes in these variab...
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| Veröffentlicht in: | Annals of nutrition and metabolism 2013-01, Vol.63 (3), p.216-222 |
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| container_title | Annals of nutrition and metabolism |
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| creator | Jiménez, Miguel Valle Martos, Rosario Morales, Rosario M. Valle, Rosario Cañete, María Dolores Urbano, M. Mar Bermudo, Francisco Cañete, Ramón |
| description | Background/Aims: The metabolic syndrome (MS) is associated with insulin resistance (IR), inappropriate fibrinolysis and high plasma leptin concentrations. The aim of this study was to quantify fibrinolysis and MS-related variables in obese prepubertal children and to evaluate changes in these variables as a result of improved body mass index (BMI), IR and leptin levels following 9 months of treatment. Methods: The homeostasis model assessment for insulin resistance (HOMA-IR), leptin, plasminogen activator inhibitor-1 (PAI-1) and lipid profile were studied at baseline in obese (n = 50) and nonobese children (n = 50), and after 9 months of treatment in obese children. Results: In the cross-sectional study the mean values for insulin, HOMA-IR, triglycerides, leptin and PAI-1 were significantly higher in obese children than in controls. High-density lipoprotein cholesterol (HDLc) and apolipoprotein A-1 were significantly lower. In the longitudinal study, after 9 months, children with lowered BMI standard deviation score displayed a significant decrease in insulin, HOMA-IR, PAI-1, leptin and triglyceride levels, and an increase in HDLc. Only leptin proved to be an independent predictive factor for changes in PAI-1 (p = 0.010). Conclusion: Obesity-linked disorders appear in obese children prior to puberty; these disorders can be improved by decreasing BMI. Changes in leptin levels were found to independently predict changes in PAI-1 in obese children and can help to diagnose complications associated with the obesity. |
| doi_str_mv | 10.1159/000351597 |
| format | Article |
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Mar ; Bermudo, Francisco ; Cañete, Ramón</creator><creatorcontrib>Jiménez, Miguel Valle ; Martos, Rosario ; Morales, Rosario M. ; Valle, Rosario ; Cañete, María Dolores ; Urbano, M. Mar ; Bermudo, Francisco ; Cañete, Ramón</creatorcontrib><description>Background/Aims: The metabolic syndrome (MS) is associated with insulin resistance (IR), inappropriate fibrinolysis and high plasma leptin concentrations. The aim of this study was to quantify fibrinolysis and MS-related variables in obese prepubertal children and to evaluate changes in these variables as a result of improved body mass index (BMI), IR and leptin levels following 9 months of treatment. Methods: The homeostasis model assessment for insulin resistance (HOMA-IR), leptin, plasminogen activator inhibitor-1 (PAI-1) and lipid profile were studied at baseline in obese (n = 50) and nonobese children (n = 50), and after 9 months of treatment in obese children. Results: In the cross-sectional study the mean values for insulin, HOMA-IR, triglycerides, leptin and PAI-1 were significantly higher in obese children than in controls. High-density lipoprotein cholesterol (HDLc) and apolipoprotein A-1 were significantly lower. In the longitudinal study, after 9 months, children with lowered BMI standard deviation score displayed a significant decrease in insulin, HOMA-IR, PAI-1, leptin and triglyceride levels, and an increase in HDLc. Only leptin proved to be an independent predictive factor for changes in PAI-1 (p = 0.010). Conclusion: Obesity-linked disorders appear in obese children prior to puberty; these disorders can be improved by decreasing BMI. Changes in leptin levels were found to independently predict changes in PAI-1 in obese children and can help to diagnose complications associated with the obesity.</description><identifier>ISSN: 0250-6807</identifier><identifier>EISSN: 1421-9697</identifier><identifier>DOI: 10.1159/000351597</identifier><identifier>PMID: 24135306</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Apolipoprotein A-I - blood ; Body Mass Index ; Child ; Childrens health ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; Female ; Humans ; Insulin - blood ; Insulin Resistance ; Leptin - blood ; Longitudinal Studies ; Male ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Metabolic Syndrome - therapy ; Obesity ; Obesity - blood ; Obesity - complications ; Obesity - therapy ; Original Paper ; Plasminogen Activator Inhibitor 1 - blood ; Studies ; Triglycerides - blood</subject><ispartof>Annals of nutrition and metabolism, 2013-01, Vol.63 (3), p.216-222</ispartof><rights>2013 S. Karger AG</rights><rights>2013 S. Karger AG, Basel</rights><rights>Copyright (c) 2013 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-51bbfd5e884169ad38ee7e2621d281ba56814bf270d4d2e7098455cd7a56021c3</citedby><cites>FETCH-LOGICAL-c422t-51bbfd5e884169ad38ee7e2621d281ba56814bf270d4d2e7098455cd7a56021c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48508369$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48508369$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2429,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24135306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jiménez, Miguel Valle</creatorcontrib><creatorcontrib>Martos, Rosario</creatorcontrib><creatorcontrib>Morales, Rosario M.</creatorcontrib><creatorcontrib>Valle, Rosario</creatorcontrib><creatorcontrib>Cañete, María Dolores</creatorcontrib><creatorcontrib>Urbano, M. Mar</creatorcontrib><creatorcontrib>Bermudo, Francisco</creatorcontrib><creatorcontrib>Cañete, Ramón</creatorcontrib><title>Relationship between Changes in Plasma Leptin Concentrations and Plasminogen Activator Inhibitor-1 in Obese Prepubertal Children after Nine Months of Treatment</title><title>Annals of nutrition and metabolism</title><addtitle>Ann Nutr Metab</addtitle><description>Background/Aims: The metabolic syndrome (MS) is associated with insulin resistance (IR), inappropriate fibrinolysis and high plasma leptin concentrations. The aim of this study was to quantify fibrinolysis and MS-related variables in obese prepubertal children and to evaluate changes in these variables as a result of improved body mass index (BMI), IR and leptin levels following 9 months of treatment. Methods: The homeostasis model assessment for insulin resistance (HOMA-IR), leptin, plasminogen activator inhibitor-1 (PAI-1) and lipid profile were studied at baseline in obese (n = 50) and nonobese children (n = 50), and after 9 months of treatment in obese children. Results: In the cross-sectional study the mean values for insulin, HOMA-IR, triglycerides, leptin and PAI-1 were significantly higher in obese children than in controls. High-density lipoprotein cholesterol (HDLc) and apolipoprotein A-1 were significantly lower. In the longitudinal study, after 9 months, children with lowered BMI standard deviation score displayed a significant decrease in insulin, HOMA-IR, PAI-1, leptin and triglyceride levels, and an increase in HDLc. Only leptin proved to be an independent predictive factor for changes in PAI-1 (p = 0.010). Conclusion: Obesity-linked disorders appear in obese children prior to puberty; these disorders can be improved by decreasing BMI. Changes in leptin levels were found to independently predict changes in PAI-1 in obese children and can help to diagnose complications associated with the obesity.</description><subject>Apolipoprotein A-I - blood</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Childrens health</subject><subject>Cholesterol, HDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Leptin - blood</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - therapy</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - therapy</subject><subject>Original Paper</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Studies</subject><subject>Triglycerides - blood</subject><issn>0250-6807</issn><issn>1421-9697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU9v1DAQxS0EokvhwB2QJS5wCNiOHTvHasWfSltaoXKO7GSy6yWxU9sB9dP0q-IqJYeePNb7vTejGYReU_KJUlF_JoSUIhfyCdpQzmhRV7V8ijaECVJUisgT9CLGIyGUKS6eoxPGaSlKUm3Q3U8YdLLexYOdsIH0F8Dh7UG7PURsHb4adBw13sGU8m_rXQsuhcWCtesWwDq_z76zNtk_OvmAz93BGpurgt6nXBqIgK8CTLOBkPSQW9ihC9mj-wQB_7AO8IV36RCx7_F1AJ3G3OkletbrIcKrh_cU_fr65Xr7vdhdfjvfnu2KljOWCkGN6TsBSnFa1borFYAEVjHaMUWNFpWi3PRMko53DCSp8yJE28msEEbb8hR9WHKn4G9miKkZbWxhGLQDP8eG8ppIxQiVGX3_CD36Obg8XaYkrcqSyTpTHxeqDT7GAH0zBTvqcNtQ0txfrVmvltl3D4mzGaFbyf9nysCbBfitwx7CCqz-t4t8jHnjq8qVIKqs6vIfiLKlcg</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Jiménez, Miguel Valle</creator><creator>Martos, Rosario</creator><creator>Morales, Rosario M.</creator><creator>Valle, Rosario</creator><creator>Cañete, María Dolores</creator><creator>Urbano, M. 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Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Relationship between Changes in Plasma Leptin Concentrations and Plasminogen Activator Inhibitor-1 in Obese Prepubertal Children after Nine Months of Treatment</title><author>Jiménez, Miguel Valle ; Martos, Rosario ; Morales, Rosario M. ; Valle, Rosario ; Cañete, María Dolores ; Urbano, M. 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Mar</au><au>Bermudo, Francisco</au><au>Cañete, Ramón</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Changes in Plasma Leptin Concentrations and Plasminogen Activator Inhibitor-1 in Obese Prepubertal Children after Nine Months of Treatment</atitle><jtitle>Annals of nutrition and metabolism</jtitle><addtitle>Ann Nutr Metab</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>63</volume><issue>3</issue><spage>216</spage><epage>222</epage><pages>216-222</pages><issn>0250-6807</issn><eissn>1421-9697</eissn><abstract>Background/Aims: The metabolic syndrome (MS) is associated with insulin resistance (IR), inappropriate fibrinolysis and high plasma leptin concentrations. The aim of this study was to quantify fibrinolysis and MS-related variables in obese prepubertal children and to evaluate changes in these variables as a result of improved body mass index (BMI), IR and leptin levels following 9 months of treatment. Methods: The homeostasis model assessment for insulin resistance (HOMA-IR), leptin, plasminogen activator inhibitor-1 (PAI-1) and lipid profile were studied at baseline in obese (n = 50) and nonobese children (n = 50), and after 9 months of treatment in obese children. Results: In the cross-sectional study the mean values for insulin, HOMA-IR, triglycerides, leptin and PAI-1 were significantly higher in obese children than in controls. High-density lipoprotein cholesterol (HDLc) and apolipoprotein A-1 were significantly lower. In the longitudinal study, after 9 months, children with lowered BMI standard deviation score displayed a significant decrease in insulin, HOMA-IR, PAI-1, leptin and triglyceride levels, and an increase in HDLc. Only leptin proved to be an independent predictive factor for changes in PAI-1 (p = 0.010). Conclusion: Obesity-linked disorders appear in obese children prior to puberty; these disorders can be improved by decreasing BMI. Changes in leptin levels were found to independently predict changes in PAI-1 in obese children and can help to diagnose complications associated with the obesity.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>24135306</pmid><doi>10.1159/000351597</doi><tpages>7</tpages></addata></record> |
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| ispartof | Annals of nutrition and metabolism, 2013-01, Vol.63 (3), p.216-222 |
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| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Karger Journals Complete; Alma/SFX Local Collection |
| subjects | Apolipoprotein A-I - blood Body Mass Index Child Childrens health Cholesterol, HDL - blood Cross-Sectional Studies Female Humans Insulin - blood Insulin Resistance Leptin - blood Longitudinal Studies Male Metabolic disorders Metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - complications Metabolic Syndrome - therapy Obesity Obesity - blood Obesity - complications Obesity - therapy Original Paper Plasminogen Activator Inhibitor 1 - blood Studies Triglycerides - blood |
| title | Relationship between Changes in Plasma Leptin Concentrations and Plasminogen Activator Inhibitor-1 in Obese Prepubertal Children after Nine Months of Treatment |
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