Preparation of ferric ion crosslinked acrylamide grafted poly (vinyl alcohol)/sodium alginate microspheres and application in controlled release of anticancer drug 5-fluorouracil

Abstract Ionically crosslinked microspheres of acrylamide (AAm) grafted poly (vinyl alcohol) (PVA)/sodium alginate (NaAlg) were prepared by crosslinking with FeCl3 and 5-fluorouracil (5-FU), which is an anticancer drug and was successfully encapsulated into the microspheres. The graft copolymer (PVA...

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Veröffentlicht in:	Drug delivery 2014-05, Vol.21 (3), p.213-220
Hauptverfasser:	anl, Oya, Olukman, Merve
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorouracil Acrylamides - chemistry Alginates - chemistry anticancer drug Antimetabolites, Antineoplastic - chemistry Chemistry, Pharmaceutical Chlorides - chemistry Cross-Linking Reagents - chemistry Delayed-Action Preparations drug delivery systems Ferric Compounds - chemistry Fluorouracil - chemistry Glucuronic Acid - chemistry graft copolymer Hexuronic Acids - chemistry Hydrogen-Ion Concentration interpenetrating polymer networks Kinetics Microscopy, Electron, Scanning Microspheres Models, Chemical Particle Size Polyvinyl Alcohol - chemistry Solubility Spectroscopy, Fourier Transform Infrared Surface Properties Technology, Pharmaceutical - methods
Online-Zugang:	Volltext
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