Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition
In the representative gut bacterium Lactobacillus plantarum , we identified genes encoding the enzymes involved in a saturation metabolism of polyunsaturated fatty acids and revealed in detail the metabolic pathway that generates hydroxy fatty acids, oxo fatty acids, conjugated fatty acids, and part...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2013-10, Vol.110 (44), p.17808-17813 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 17813 |
|---|---|
| container_issue | 44 |
| container_start_page | 17808 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 110 |
| creator | Kishino, Shigenobu Takeuchi, Michiki Park, Si-Bum Hirata, Akiko Kitamura, Nahoko Kunisawa, Jun Kiyono, Hiroshi Iwamoto, Ryo Isobe, Yosuke Arita, Makoto Arai, Hiroyuki Ueda, Kazumitsu Shima, Jun Takahashi, Satomi Yokozeki, Kenzo Shimizu, Sakayu Ogawa, Jun |
| description | In the representative gut bacterium Lactobacillus plantarum , we identified genes encoding the enzymes involved in a saturation metabolism of polyunsaturated fatty acids and revealed in detail the metabolic pathway that generates hydroxy fatty acids, oxo fatty acids, conjugated fatty acids, and partially saturated trans -fatty acids as intermediates. Furthermore, we observed these intermediates, especially hydroxy fatty acids, in host organs. Levels of hydroxy fatty acids were much higher in specific pathogen-free mice than in germ-free mice, indicating that these fatty acids are generated through polyunsaturated fatty acids metabolism of gastrointestinal microorganisms. These findings suggested that lipid metabolism by gastrointestinal microbes affects the health of the host by modifying fatty acid composition. |
| doi_str_mv | 10.1073/pnas.1312937110 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmed_primary_24127592</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>23754394</jstor_id><sourcerecordid>23754394</sourcerecordid><originalsourceid>FETCH-LOGICAL-c701t-768fbbf312eceeb7f826b75bf7e040f46b62f5eb9f9ca2928cdfac9e4f8b13013</originalsourceid><addsrcrecordid>eNqFkUFv1DAQhSMEotvCmRMQiQuXtDO2E9sXJFRRQKoEEvRs2V5761U2XuwEaf89jrJsgQsnW_O-eePxq6oXCJcInF7tB50vkSKRlCPCo2qFILHpmITH1QqA8EYwws6q85y3ACBbAU-rM8KQ8FaSVWW-xv4wDVmPU9KjW9dej-Oh1jas62MxxKE2h3ozjXWv7RjsoppydynoWnvvSnnY1PcxFybsi2rjbh9zmJufVU-87rN7fjwvqrubD9-vPzW3Xz5-vn5_21gOODa8E94YX3Zx1jnDvSCd4a3x3AEDzzrTEd86I720mkgi7NprKx3zwiAFpBfVu8V3P5mdW1s3jEn3ap_CTqeDijqov5Uh3KtN_KmowI6xrhi8PRqk-GNyeVS7kK3rez24OGWFAigiYRz_jzLGmewkpQV98w-6jVMayk_MlEQpCZ-pq4WyKeacnD-9G0HNUas5avUQdel49ee6J_53tgWoj8DcebIrfowp5AJEQV4uyDaPMT1YUN4yKlnRXy-611HpTQpZ3X0jgB0AljFU0l874sR5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449199273</pqid></control><display><type>article</type><title>Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Kishino, Shigenobu ; Takeuchi, Michiki ; Park, Si-Bum ; Hirata, Akiko ; Kitamura, Nahoko ; Kunisawa, Jun ; Kiyono, Hiroshi ; Iwamoto, Ryo ; Isobe, Yosuke ; Arita, Makoto ; Arai, Hiroyuki ; Ueda, Kazumitsu ; Shima, Jun ; Takahashi, Satomi ; Yokozeki, Kenzo ; Shimizu, Sakayu ; Ogawa, Jun</creator><creatorcontrib>Kishino, Shigenobu ; Takeuchi, Michiki ; Park, Si-Bum ; Hirata, Akiko ; Kitamura, Nahoko ; Kunisawa, Jun ; Kiyono, Hiroshi ; Iwamoto, Ryo ; Isobe, Yosuke ; Arita, Makoto ; Arai, Hiroyuki ; Ueda, Kazumitsu ; Shima, Jun ; Takahashi, Satomi ; Yokozeki, Kenzo ; Shimizu, Sakayu ; Ogawa, Jun</creatorcontrib><description>In the representative gut bacterium Lactobacillus plantarum , we identified genes encoding the enzymes involved in a saturation metabolism of polyunsaturated fatty acids and revealed in detail the metabolic pathway that generates hydroxy fatty acids, oxo fatty acids, conjugated fatty acids, and partially saturated trans -fatty acids as intermediates. Furthermore, we observed these intermediates, especially hydroxy fatty acids, in host organs. Levels of hydroxy fatty acids were much higher in specific pathogen-free mice than in germ-free mice, indicating that these fatty acids are generated through polyunsaturated fatty acids metabolism of gastrointestinal microorganisms. These findings suggested that lipid metabolism by gastrointestinal microbes affects the health of the host by modifying fatty acid composition.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1312937110</identifier><identifier>PMID: 24127592</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; biochemical pathways ; Biological Sciences ; Chromatography, Liquid ; Cloning, Molecular ; Conjugated linoleic acids ; DNA Primers - genetics ; Enzymes ; fatty acid composition ; fatty acid metabolism ; Fatty acids ; Fatty Acids, Unsaturated - metabolism ; Gastroenterology ; gastrointestinal system ; Gastrointestinal Tract - metabolism ; Gastrointestinal Tract - microbiology ; genes ; Hydroxy acids ; hydroxy fatty acids ; intestinal microorganisms ; Lactic acid bacteria ; Lactobacillus plantarum ; Lactobacillus plantarum - enzymology ; Lactobacillus plantarum - metabolism ; Lipid metabolism ; Lipid Metabolism - physiology ; Lipids ; Metabolic Networks and Pathways - genetics ; Metabolic Networks and Pathways - physiology ; Metabolism ; Mice ; Microorganisms ; Molecular Sequence Data ; Multigene Family - genetics ; Oxidation-Reduction ; Oxidoreductases - genetics ; Oxidoreductases - metabolism ; polyunsaturated fatty acids ; Rodents ; Sequence Analysis, DNA ; Sequence Homology ; specific pathogen-free animals ; Specific Pathogen-Free Organisms ; Tandem Mass Spectrometry ; Trans fatty acids ; Unsaturated fatty acids</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (44), p.17808-17813</ispartof><rights>copyright © 1993–2008 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Oct 30, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c701t-768fbbf312eceeb7f826b75bf7e040f46b62f5eb9f9ca2928cdfac9e4f8b13013</citedby><cites>FETCH-LOGICAL-c701t-768fbbf312eceeb7f826b75bf7e040f46b62f5eb9f9ca2928cdfac9e4f8b13013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/110/44.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23754394$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23754394$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24127592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kishino, Shigenobu</creatorcontrib><creatorcontrib>Takeuchi, Michiki</creatorcontrib><creatorcontrib>Park, Si-Bum</creatorcontrib><creatorcontrib>Hirata, Akiko</creatorcontrib><creatorcontrib>Kitamura, Nahoko</creatorcontrib><creatorcontrib>Kunisawa, Jun</creatorcontrib><creatorcontrib>Kiyono, Hiroshi</creatorcontrib><creatorcontrib>Iwamoto, Ryo</creatorcontrib><creatorcontrib>Isobe, Yosuke</creatorcontrib><creatorcontrib>Arita, Makoto</creatorcontrib><creatorcontrib>Arai, Hiroyuki</creatorcontrib><creatorcontrib>Ueda, Kazumitsu</creatorcontrib><creatorcontrib>Shima, Jun</creatorcontrib><creatorcontrib>Takahashi, Satomi</creatorcontrib><creatorcontrib>Yokozeki, Kenzo</creatorcontrib><creatorcontrib>Shimizu, Sakayu</creatorcontrib><creatorcontrib>Ogawa, Jun</creatorcontrib><title>Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>In the representative gut bacterium Lactobacillus plantarum , we identified genes encoding the enzymes involved in a saturation metabolism of polyunsaturated fatty acids and revealed in detail the metabolic pathway that generates hydroxy fatty acids, oxo fatty acids, conjugated fatty acids, and partially saturated trans -fatty acids as intermediates. Furthermore, we observed these intermediates, especially hydroxy fatty acids, in host organs. Levels of hydroxy fatty acids were much higher in specific pathogen-free mice than in germ-free mice, indicating that these fatty acids are generated through polyunsaturated fatty acids metabolism of gastrointestinal microorganisms. These findings suggested that lipid metabolism by gastrointestinal microbes affects the health of the host by modifying fatty acid composition.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>biochemical pathways</subject><subject>Biological Sciences</subject><subject>Chromatography, Liquid</subject><subject>Cloning, Molecular</subject><subject>Conjugated linoleic acids</subject><subject>DNA Primers - genetics</subject><subject>Enzymes</subject><subject>fatty acid composition</subject><subject>fatty acid metabolism</subject><subject>Fatty acids</subject><subject>Fatty Acids, Unsaturated - metabolism</subject><subject>Gastroenterology</subject><subject>gastrointestinal system</subject><subject>Gastrointestinal Tract - metabolism</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>genes</subject><subject>Hydroxy acids</subject><subject>hydroxy fatty acids</subject><subject>intestinal microorganisms</subject><subject>Lactic acid bacteria</subject><subject>Lactobacillus plantarum</subject><subject>Lactobacillus plantarum - enzymology</subject><subject>Lactobacillus plantarum - metabolism</subject><subject>Lipid metabolism</subject><subject>Lipid Metabolism - physiology</subject><subject>Lipids</subject><subject>Metabolic Networks and Pathways - genetics</subject><subject>Metabolic Networks and Pathways - physiology</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Microorganisms</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family - genetics</subject><subject>Oxidation-Reduction</subject><subject>Oxidoreductases - genetics</subject><subject>Oxidoreductases - metabolism</subject><subject>polyunsaturated fatty acids</subject><subject>Rodents</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology</subject><subject>specific pathogen-free animals</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Tandem Mass Spectrometry</subject><subject>Trans fatty acids</subject><subject>Unsaturated fatty acids</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhSMEotvCmRMQiQuXtDO2E9sXJFRRQKoEEvRs2V5761U2XuwEaf89jrJsgQsnW_O-eePxq6oXCJcInF7tB50vkSKRlCPCo2qFILHpmITH1QqA8EYwws6q85y3ACBbAU-rM8KQ8FaSVWW-xv4wDVmPU9KjW9dej-Oh1jas62MxxKE2h3ozjXWv7RjsoppydynoWnvvSnnY1PcxFybsi2rjbh9zmJufVU-87rN7fjwvqrubD9-vPzW3Xz5-vn5_21gOODa8E94YX3Zx1jnDvSCd4a3x3AEDzzrTEd86I720mkgi7NprKx3zwiAFpBfVu8V3P5mdW1s3jEn3ap_CTqeDijqov5Uh3KtN_KmowI6xrhi8PRqk-GNyeVS7kK3rez24OGWFAigiYRz_jzLGmewkpQV98w-6jVMayk_MlEQpCZ-pq4WyKeacnD-9G0HNUas5avUQdel49ee6J_53tgWoj8DcebIrfowp5AJEQV4uyDaPMT1YUN4yKlnRXy-611HpTQpZ3X0jgB0AljFU0l874sR5</recordid><startdate>20131029</startdate><enddate>20131029</enddate><creator>Kishino, Shigenobu</creator><creator>Takeuchi, Michiki</creator><creator>Park, Si-Bum</creator><creator>Hirata, Akiko</creator><creator>Kitamura, Nahoko</creator><creator>Kunisawa, Jun</creator><creator>Kiyono, Hiroshi</creator><creator>Iwamoto, Ryo</creator><creator>Isobe, Yosuke</creator><creator>Arita, Makoto</creator><creator>Arai, Hiroyuki</creator><creator>Ueda, Kazumitsu</creator><creator>Shima, Jun</creator><creator>Takahashi, Satomi</creator><creator>Yokozeki, Kenzo</creator><creator>Shimizu, Sakayu</creator><creator>Ogawa, Jun</creator><general>National Academy of Sciences</general><general>NATIONAL ACADEMY OF SCIENCES</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20131029</creationdate><title>Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition</title><author>Kishino, Shigenobu ; Takeuchi, Michiki ; Park, Si-Bum ; Hirata, Akiko ; Kitamura, Nahoko ; Kunisawa, Jun ; Kiyono, Hiroshi ; Iwamoto, Ryo ; Isobe, Yosuke ; Arita, Makoto ; Arai, Hiroyuki ; Ueda, Kazumitsu ; Shima, Jun ; Takahashi, Satomi ; Yokozeki, Kenzo ; Shimizu, Sakayu ; Ogawa, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c701t-768fbbf312eceeb7f826b75bf7e040f46b62f5eb9f9ca2928cdfac9e4f8b13013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>biochemical pathways</topic><topic>Biological Sciences</topic><topic>Chromatography, Liquid</topic><topic>Cloning, Molecular</topic><topic>Conjugated linoleic acids</topic><topic>DNA Primers - genetics</topic><topic>Enzymes</topic><topic>fatty acid composition</topic><topic>fatty acid metabolism</topic><topic>Fatty acids</topic><topic>Fatty Acids, Unsaturated - metabolism</topic><topic>Gastroenterology</topic><topic>gastrointestinal system</topic><topic>Gastrointestinal Tract - metabolism</topic><topic>Gastrointestinal Tract - microbiology</topic><topic>genes</topic><topic>Hydroxy acids</topic><topic>hydroxy fatty acids</topic><topic>intestinal microorganisms</topic><topic>Lactic acid bacteria</topic><topic>Lactobacillus plantarum</topic><topic>Lactobacillus plantarum - enzymology</topic><topic>Lactobacillus plantarum - metabolism</topic><topic>Lipid metabolism</topic><topic>Lipid Metabolism - physiology</topic><topic>Lipids</topic><topic>Metabolic Networks and Pathways - genetics</topic><topic>Metabolic Networks and Pathways - physiology</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Microorganisms</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family - genetics</topic><topic>Oxidation-Reduction</topic><topic>Oxidoreductases - genetics</topic><topic>Oxidoreductases - metabolism</topic><topic>polyunsaturated fatty acids</topic><topic>Rodents</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology</topic><topic>specific pathogen-free animals</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Tandem Mass Spectrometry</topic><topic>Trans fatty acids</topic><topic>Unsaturated fatty acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kishino, Shigenobu</creatorcontrib><creatorcontrib>Takeuchi, Michiki</creatorcontrib><creatorcontrib>Park, Si-Bum</creatorcontrib><creatorcontrib>Hirata, Akiko</creatorcontrib><creatorcontrib>Kitamura, Nahoko</creatorcontrib><creatorcontrib>Kunisawa, Jun</creatorcontrib><creatorcontrib>Kiyono, Hiroshi</creatorcontrib><creatorcontrib>Iwamoto, Ryo</creatorcontrib><creatorcontrib>Isobe, Yosuke</creatorcontrib><creatorcontrib>Arita, Makoto</creatorcontrib><creatorcontrib>Arai, Hiroyuki</creatorcontrib><creatorcontrib>Ueda, Kazumitsu</creatorcontrib><creatorcontrib>Shima, Jun</creatorcontrib><creatorcontrib>Takahashi, Satomi</creatorcontrib><creatorcontrib>Yokozeki, Kenzo</creatorcontrib><creatorcontrib>Shimizu, Sakayu</creatorcontrib><creatorcontrib>Ogawa, Jun</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kishino, Shigenobu</au><au>Takeuchi, Michiki</au><au>Park, Si-Bum</au><au>Hirata, Akiko</au><au>Kitamura, Nahoko</au><au>Kunisawa, Jun</au><au>Kiyono, Hiroshi</au><au>Iwamoto, Ryo</au><au>Isobe, Yosuke</au><au>Arita, Makoto</au><au>Arai, Hiroyuki</au><au>Ueda, Kazumitsu</au><au>Shima, Jun</au><au>Takahashi, Satomi</au><au>Yokozeki, Kenzo</au><au>Shimizu, Sakayu</au><au>Ogawa, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2013-10-29</date><risdate>2013</risdate><volume>110</volume><issue>44</issue><spage>17808</spage><epage>17813</epage><pages>17808-17813</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>In the representative gut bacterium Lactobacillus plantarum , we identified genes encoding the enzymes involved in a saturation metabolism of polyunsaturated fatty acids and revealed in detail the metabolic pathway that generates hydroxy fatty acids, oxo fatty acids, conjugated fatty acids, and partially saturated trans -fatty acids as intermediates. Furthermore, we observed these intermediates, especially hydroxy fatty acids, in host organs. Levels of hydroxy fatty acids were much higher in specific pathogen-free mice than in germ-free mice, indicating that these fatty acids are generated through polyunsaturated fatty acids metabolism of gastrointestinal microorganisms. These findings suggested that lipid metabolism by gastrointestinal microbes affects the health of the host by modifying fatty acid composition.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>24127592</pmid><doi>10.1073/pnas.1312937110</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (44), p.17808-17813 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pubmed_primary_24127592 |
| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Animals Base Sequence biochemical pathways Biological Sciences Chromatography, Liquid Cloning, Molecular Conjugated linoleic acids DNA Primers - genetics Enzymes fatty acid composition fatty acid metabolism Fatty acids Fatty Acids, Unsaturated - metabolism Gastroenterology gastrointestinal system Gastrointestinal Tract - metabolism Gastrointestinal Tract - microbiology genes Hydroxy acids hydroxy fatty acids intestinal microorganisms Lactic acid bacteria Lactobacillus plantarum Lactobacillus plantarum - enzymology Lactobacillus plantarum - metabolism Lipid metabolism Lipid Metabolism - physiology Lipids Metabolic Networks and Pathways - genetics Metabolic Networks and Pathways - physiology Metabolism Mice Microorganisms Molecular Sequence Data Multigene Family - genetics Oxidation-Reduction Oxidoreductases - genetics Oxidoreductases - metabolism polyunsaturated fatty acids Rodents Sequence Analysis, DNA Sequence Homology specific pathogen-free animals Specific Pathogen-Free Organisms Tandem Mass Spectrometry Trans fatty acids Unsaturated fatty acids |
| title | Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T17%3A22%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polyunsaturated%20fatty%20acid%20saturation%20by%20gut%20lactic%20acid%20bacteria%20affecting%20host%20lipid%20composition&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Kishino,%20Shigenobu&rft.date=2013-10-29&rft.volume=110&rft.issue=44&rft.spage=17808&rft.epage=17813&rft.pages=17808-17813&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.1312937110&rft_dat=%3Cjstor_pubme%3E23754394%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449199273&rft_id=info:pmid/24127592&rft_jstor_id=23754394&rfr_iscdi=true |