Pou2f3/Skn-1a Is Necessary for the Generation or Differentiation of Solitary Chemosensory Cells in the Anterior Nasal Cavity

Solitary chemosensory cells in the non-neuronal epithelium of the anterior nasal cavity have bitter taste cell-like molecular characteristics and are involved in the detection of noxious substances. Here, we demonstrate that Pou2f3/Skn-1a, which is necessary for generation of sweet, umami, and bitte...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2013, Vol.77 (10), p.2154-2156
Hauptverfasser:	OHMOTO, Makoto, YAMAGUCHI, Tatsuya, YAMASHITA, Junpei, BACHMANOV, Alexander A, HIROTA, Junji, MATSUMOTO, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation differentiation Epithelial Cells - cytology Epithelial Cells - metabolism Gene Knockout Techniques Mice Nasal Cavity - cytology Octamer Transcription Factors - deficiency Octamer Transcription Factors - genetics Octamer Transcription Factors - metabolism Pou2f3 solitary chemosensory cell taste cell transcription factor
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Beschreibung
Zusammenfassung:	Solitary chemosensory cells in the non-neuronal epithelium of the anterior nasal cavity have bitter taste cell-like molecular characteristics and are involved in the detection of noxious substances. Here, we demonstrate that Pou2f3/Skn-1a, which is necessary for generation of sweet, umami, and bitter taste cells, is also necessary for the generation or differentiation of solitary chemosensory cells.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.130454