Heart rate variability on antihypertensive drugs in black patients living in sub-Saharan Africa
Abstract Background. Compared with Caucasians, African Americans have lower heart rate variability (HRV) in the high-frequency domain, but there are no studies in blacks born and living in Africa. Methods. In the Newer versus Older Antihypertensive agents in African Hypertensive patients trial (NCT0...
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| creator | Osakwe, Chukwunomso E. Jacobs, Lotte Anisiuba, Benedict C. Ndiaye, Mouhamado B. Lemogoum, Daniel Ijoma, Chinwuba K. Kamdem, Marius M. Thijs, Lutgarde Boombhi, Hilaire J. Kaptue, Joseph Kolo, Philip M. Mipinda, Jean B. Odili, Augustine N. Ezeala-Adikaibe, Birinus Kingue, Samuel Omotoso, Babatunde A. Ba, Serigne A. Ulasi, Ifeoma I. M'buyamba-Kabangu, Jean-Rene Staessen, Jan A. |
| description | Abstract
Background. Compared with Caucasians, African Americans have lower heart rate variability (HRV) in the high-frequency domain, but there are no studies in blacks born and living in Africa. Methods. In the Newer versus Older Antihypertensive agents in African Hypertensive patients trial (NCT01030458), patients (30-69 years) with uncomplicated hypertension (140-179/90-109 mmHg) were randomized to single-pill combinations of bisoprolol/hydrochlorothiazide (R) or amlodipine/valsartan (E). 72 R and 84 E patients underwent 5-min ECG recordings at randomization and 8, 16 and 24 weeks. HRV was determined by fast Fourier transform and autoregressive modelling. Results. Heart rate decreased by 9.5 beats/min in R patients with no change in E patients (− 2.2 beats/min). R patients had reduced total (− 0.13 ms²; p = 0.0038) and low-frequency power (− 3.6 nu; p = 0.057), higher high-frequency (+ 3.3 nu; p = 0.050) and a reduced low- to high-frequency ratio (− 0.08; p = 0.040). With adjustment for heart rate, these differences disappeared, except for the reduced low-frequency power in the R group (− 4.67 nu; p = 0.02). Analyses confined to 39 R and 47 E patients with HRV measurements at all visits or based on autoregressive modelling were confirmatory. Conclusion. In native black African patients, antihypertensive drugs modulate HRV, an index of autonomous nervous tone. However, these effects were mediated by changes in heart rate except for low-frequency variability, which was reduced on beta blockade independent of heart rate. |
| doi_str_mv | 10.3109/08037051.2013.836810 |
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| fullrecord | <record><control><sourceid>informahealthcare_pubme</sourceid><recordid>TN_cdi_pubmed_primary_24066715</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_3109_08037051_2013_836810</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-df453dfa52a3af3d68df44ce929653551f10425b488e87ced4bf9397cbac22343</originalsourceid><addsrcrecordid>eNp9kN1u1DAQRi1ERZfCGyDkF8ji3yS-KaoqSpEqcUG5tiaOvXHJOquxd9G-fRMtrehNryx5zvfN6BDyibO15Mx8YS2TDdN8LRiX61bWLWdvyIrXmlfcGPOWrBakWphz8j7nBzaDkrF35FwoVtcN1ytibz1goQjF0wNghC6OsRzplCikEofjzmPxKceDpz3uN5nGRLsR3B-6gxJ9KpmO8RDTZhnkfVf9ggEQEr0KGB18IGcBxuw__nsvyO-bb_fXt9Xdz-8_rq_uKqe5KVUflJZ9AC1AQpB93c4_ynkjTK2l1jxwpoTuVNv6tnG-V10w0jSuAyeEVPKCXJ56d_tu63s3H4Yw2h3GLeDRThDty0mKg91MB6uYNkI0c4E6FTicckYfnrOc2UW4fRJuF-H2JHyOff5_73PoyfAMfD0BMYUJt_B3wrG3BY7jhGH25GJe6l9dcfmiYfAwlsEBevsw7THNWl-_8RE_RqWn</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Heart rate variability on antihypertensive drugs in black patients living in sub-Saharan Africa</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Osakwe, Chukwunomso E. ; Jacobs, Lotte ; Anisiuba, Benedict C. ; Ndiaye, Mouhamado B. ; Lemogoum, Daniel ; Ijoma, Chinwuba K. ; Kamdem, Marius M. ; Thijs, Lutgarde ; Boombhi, Hilaire J. ; Kaptue, Joseph ; Kolo, Philip M. ; Mipinda, Jean B. ; Odili, Augustine N. ; Ezeala-Adikaibe, Birinus ; Kingue, Samuel ; Omotoso, Babatunde A. ; Ba, Serigne A. ; Ulasi, Ifeoma I. ; M'buyamba-Kabangu, Jean-Rene ; Staessen, Jan A.</creator><creatorcontrib>Osakwe, Chukwunomso E. ; Jacobs, Lotte ; Anisiuba, Benedict C. ; Ndiaye, Mouhamado B. ; Lemogoum, Daniel ; Ijoma, Chinwuba K. ; Kamdem, Marius M. ; Thijs, Lutgarde ; Boombhi, Hilaire J. ; Kaptue, Joseph ; Kolo, Philip M. ; Mipinda, Jean B. ; Odili, Augustine N. ; Ezeala-Adikaibe, Birinus ; Kingue, Samuel ; Omotoso, Babatunde A. ; Ba, Serigne A. ; Ulasi, Ifeoma I. ; M'buyamba-Kabangu, Jean-Rene ; Staessen, Jan A. ; Newer Versus Older Antihypertensive Agents in African Hypertensive Patients Trial (NOAAH) Investigators ; On behalf of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients Trial (NOAAH) Investigators</creatorcontrib><description>Abstract
Background. Compared with Caucasians, African Americans have lower heart rate variability (HRV) in the high-frequency domain, but there are no studies in blacks born and living in Africa. Methods. In the Newer versus Older Antihypertensive agents in African Hypertensive patients trial (NCT01030458), patients (30-69 years) with uncomplicated hypertension (140-179/90-109 mmHg) were randomized to single-pill combinations of bisoprolol/hydrochlorothiazide (R) or amlodipine/valsartan (E). 72 R and 84 E patients underwent 5-min ECG recordings at randomization and 8, 16 and 24 weeks. HRV was determined by fast Fourier transform and autoregressive modelling. Results. Heart rate decreased by 9.5 beats/min in R patients with no change in E patients (− 2.2 beats/min). R patients had reduced total (− 0.13 ms²; p = 0.0038) and low-frequency power (− 3.6 nu; p = 0.057), higher high-frequency (+ 3.3 nu; p = 0.050) and a reduced low- to high-frequency ratio (− 0.08; p = 0.040). With adjustment for heart rate, these differences disappeared, except for the reduced low-frequency power in the R group (− 4.67 nu; p = 0.02). Analyses confined to 39 R and 47 E patients with HRV measurements at all visits or based on autoregressive modelling were confirmatory. Conclusion. In native black African patients, antihypertensive drugs modulate HRV, an index of autonomous nervous tone. However, these effects were mediated by changes in heart rate except for low-frequency variability, which was reduced on beta blockade independent of heart rate.</description><identifier>ISSN: 0803-7051</identifier><identifier>EISSN: 1651-1999</identifier><identifier>DOI: 10.3109/08037051.2013.836810</identifier><identifier>PMID: 24066715</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Africa South of the Sahara ; Antihypertensive Agents - therapeutic use ; Antihypertensive drugs ; blacks ; Cohort Studies ; Female ; Heart Rate - drug effects ; heart rate variability ; Humans ; Hypertension - drug therapy ; Hypertension - physiopathology ; Male ; Middle Aged ; Original ; randomized clinical trial ; sub-Saharan Africa</subject><ispartof>Blood pressure, 2014-06, Vol.23 (3), p.174-180</ispartof><rights>2014 Scandinavian Foundation for Cardiovascular Research 2014</rights><rights>2014 Scandinavian Foundation for Cardiovascular Research 2014 Scandinavian Foundation for Cardiovascular Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-df453dfa52a3af3d68df44ce929653551f10425b488e87ced4bf9397cbac22343</citedby><cites>FETCH-LOGICAL-c519t-df453dfa52a3af3d68df44ce929653551f10425b488e87ced4bf9397cbac22343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24066715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osakwe, Chukwunomso E.</creatorcontrib><creatorcontrib>Jacobs, Lotte</creatorcontrib><creatorcontrib>Anisiuba, Benedict C.</creatorcontrib><creatorcontrib>Ndiaye, Mouhamado B.</creatorcontrib><creatorcontrib>Lemogoum, Daniel</creatorcontrib><creatorcontrib>Ijoma, Chinwuba K.</creatorcontrib><creatorcontrib>Kamdem, Marius M.</creatorcontrib><creatorcontrib>Thijs, Lutgarde</creatorcontrib><creatorcontrib>Boombhi, Hilaire J.</creatorcontrib><creatorcontrib>Kaptue, Joseph</creatorcontrib><creatorcontrib>Kolo, Philip M.</creatorcontrib><creatorcontrib>Mipinda, Jean B.</creatorcontrib><creatorcontrib>Odili, Augustine N.</creatorcontrib><creatorcontrib>Ezeala-Adikaibe, Birinus</creatorcontrib><creatorcontrib>Kingue, Samuel</creatorcontrib><creatorcontrib>Omotoso, Babatunde A.</creatorcontrib><creatorcontrib>Ba, Serigne A.</creatorcontrib><creatorcontrib>Ulasi, Ifeoma I.</creatorcontrib><creatorcontrib>M'buyamba-Kabangu, Jean-Rene</creatorcontrib><creatorcontrib>Staessen, Jan A.</creatorcontrib><creatorcontrib>Newer Versus Older Antihypertensive Agents in African Hypertensive Patients Trial (NOAAH) Investigators</creatorcontrib><creatorcontrib>On behalf of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients Trial (NOAAH) Investigators</creatorcontrib><title>Heart rate variability on antihypertensive drugs in black patients living in sub-Saharan Africa</title><title>Blood pressure</title><addtitle>Blood Press</addtitle><description>Abstract
Background. Compared with Caucasians, African Americans have lower heart rate variability (HRV) in the high-frequency domain, but there are no studies in blacks born and living in Africa. Methods. In the Newer versus Older Antihypertensive agents in African Hypertensive patients trial (NCT01030458), patients (30-69 years) with uncomplicated hypertension (140-179/90-109 mmHg) were randomized to single-pill combinations of bisoprolol/hydrochlorothiazide (R) or amlodipine/valsartan (E). 72 R and 84 E patients underwent 5-min ECG recordings at randomization and 8, 16 and 24 weeks. HRV was determined by fast Fourier transform and autoregressive modelling. Results. Heart rate decreased by 9.5 beats/min in R patients with no change in E patients (− 2.2 beats/min). R patients had reduced total (− 0.13 ms²; p = 0.0038) and low-frequency power (− 3.6 nu; p = 0.057), higher high-frequency (+ 3.3 nu; p = 0.050) and a reduced low- to high-frequency ratio (− 0.08; p = 0.040). With adjustment for heart rate, these differences disappeared, except for the reduced low-frequency power in the R group (− 4.67 nu; p = 0.02). Analyses confined to 39 R and 47 E patients with HRV measurements at all visits or based on autoregressive modelling were confirmatory. Conclusion. In native black African patients, antihypertensive drugs modulate HRV, an index of autonomous nervous tone. However, these effects were mediated by changes in heart rate except for low-frequency variability, which was reduced on beta blockade independent of heart rate.</description><subject>Africa South of the Sahara</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antihypertensive drugs</subject><subject>blacks</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>heart rate variability</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>randomized clinical trial</subject><subject>sub-Saharan Africa</subject><issn>0803-7051</issn><issn>1651-1999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNp9kN1u1DAQRi1ERZfCGyDkF8ji3yS-KaoqSpEqcUG5tiaOvXHJOquxd9G-fRMtrehNryx5zvfN6BDyibO15Mx8YS2TDdN8LRiX61bWLWdvyIrXmlfcGPOWrBakWphz8j7nBzaDkrF35FwoVtcN1ytibz1goQjF0wNghC6OsRzplCikEofjzmPxKceDpz3uN5nGRLsR3B-6gxJ9KpmO8RDTZhnkfVf9ggEQEr0KGB18IGcBxuw__nsvyO-bb_fXt9Xdz-8_rq_uKqe5KVUflJZ9AC1AQpB93c4_ynkjTK2l1jxwpoTuVNv6tnG-V10w0jSuAyeEVPKCXJ56d_tu63s3H4Yw2h3GLeDRThDty0mKg91MB6uYNkI0c4E6FTicckYfnrOc2UW4fRJuF-H2JHyOff5_73PoyfAMfD0BMYUJt_B3wrG3BY7jhGH25GJe6l9dcfmiYfAwlsEBevsw7THNWl-_8RE_RqWn</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Osakwe, Chukwunomso E.</creator><creator>Jacobs, Lotte</creator><creator>Anisiuba, Benedict C.</creator><creator>Ndiaye, Mouhamado B.</creator><creator>Lemogoum, Daniel</creator><creator>Ijoma, Chinwuba K.</creator><creator>Kamdem, Marius M.</creator><creator>Thijs, Lutgarde</creator><creator>Boombhi, Hilaire J.</creator><creator>Kaptue, Joseph</creator><creator>Kolo, Philip M.</creator><creator>Mipinda, Jean B.</creator><creator>Odili, Augustine N.</creator><creator>Ezeala-Adikaibe, Birinus</creator><creator>Kingue, Samuel</creator><creator>Omotoso, Babatunde A.</creator><creator>Ba, Serigne A.</creator><creator>Ulasi, Ifeoma I.</creator><creator>M'buyamba-Kabangu, Jean-Rene</creator><creator>Staessen, Jan A.</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20140601</creationdate><title>Heart rate variability on antihypertensive drugs in black patients living in sub-Saharan Africa</title><author>Osakwe, Chukwunomso E. ; Jacobs, Lotte ; Anisiuba, Benedict C. ; Ndiaye, Mouhamado B. ; Lemogoum, Daniel ; Ijoma, Chinwuba K. ; Kamdem, Marius M. ; Thijs, Lutgarde ; Boombhi, Hilaire J. ; Kaptue, Joseph ; Kolo, Philip M. ; Mipinda, Jean B. ; Odili, Augustine N. ; Ezeala-Adikaibe, Birinus ; Kingue, Samuel ; Omotoso, Babatunde A. ; Ba, Serigne A. ; Ulasi, Ifeoma I. ; M'buyamba-Kabangu, Jean-Rene ; Staessen, Jan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-df453dfa52a3af3d68df44ce929653551f10425b488e87ced4bf9397cbac22343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Africa South of the Sahara</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antihypertensive drugs</topic><topic>blacks</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>heart rate variability</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>randomized clinical trial</topic><topic>sub-Saharan Africa</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osakwe, Chukwunomso E.</creatorcontrib><creatorcontrib>Jacobs, Lotte</creatorcontrib><creatorcontrib>Anisiuba, Benedict C.</creatorcontrib><creatorcontrib>Ndiaye, Mouhamado B.</creatorcontrib><creatorcontrib>Lemogoum, Daniel</creatorcontrib><creatorcontrib>Ijoma, Chinwuba K.</creatorcontrib><creatorcontrib>Kamdem, Marius M.</creatorcontrib><creatorcontrib>Thijs, Lutgarde</creatorcontrib><creatorcontrib>Boombhi, Hilaire J.</creatorcontrib><creatorcontrib>Kaptue, Joseph</creatorcontrib><creatorcontrib>Kolo, Philip M.</creatorcontrib><creatorcontrib>Mipinda, Jean B.</creatorcontrib><creatorcontrib>Odili, Augustine N.</creatorcontrib><creatorcontrib>Ezeala-Adikaibe, Birinus</creatorcontrib><creatorcontrib>Kingue, Samuel</creatorcontrib><creatorcontrib>Omotoso, Babatunde A.</creatorcontrib><creatorcontrib>Ba, Serigne A.</creatorcontrib><creatorcontrib>Ulasi, Ifeoma I.</creatorcontrib><creatorcontrib>M'buyamba-Kabangu, Jean-Rene</creatorcontrib><creatorcontrib>Staessen, Jan A.</creatorcontrib><creatorcontrib>Newer Versus Older Antihypertensive Agents in African Hypertensive Patients Trial (NOAAH) Investigators</creatorcontrib><creatorcontrib>On behalf of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients Trial (NOAAH) Investigators</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Blood pressure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osakwe, Chukwunomso E.</au><au>Jacobs, Lotte</au><au>Anisiuba, Benedict C.</au><au>Ndiaye, Mouhamado B.</au><au>Lemogoum, Daniel</au><au>Ijoma, Chinwuba K.</au><au>Kamdem, Marius M.</au><au>Thijs, Lutgarde</au><au>Boombhi, Hilaire J.</au><au>Kaptue, Joseph</au><au>Kolo, Philip M.</au><au>Mipinda, Jean B.</au><au>Odili, Augustine N.</au><au>Ezeala-Adikaibe, Birinus</au><au>Kingue, Samuel</au><au>Omotoso, Babatunde A.</au><au>Ba, Serigne A.</au><au>Ulasi, Ifeoma I.</au><au>M'buyamba-Kabangu, Jean-Rene</au><au>Staessen, Jan A.</au><aucorp>Newer Versus Older Antihypertensive Agents in African Hypertensive Patients Trial (NOAAH) Investigators</aucorp><aucorp>On behalf of the Newer Versus Older Antihypertensive Agents in African Hypertensive Patients Trial (NOAAH) Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart rate variability on antihypertensive drugs in black patients living in sub-Saharan Africa</atitle><jtitle>Blood pressure</jtitle><addtitle>Blood Press</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>23</volume><issue>3</issue><spage>174</spage><epage>180</epage><pages>174-180</pages><issn>0803-7051</issn><eissn>1651-1999</eissn><abstract>Abstract
Background. Compared with Caucasians, African Americans have lower heart rate variability (HRV) in the high-frequency domain, but there are no studies in blacks born and living in Africa. Methods. In the Newer versus Older Antihypertensive agents in African Hypertensive patients trial (NCT01030458), patients (30-69 years) with uncomplicated hypertension (140-179/90-109 mmHg) were randomized to single-pill combinations of bisoprolol/hydrochlorothiazide (R) or amlodipine/valsartan (E). 72 R and 84 E patients underwent 5-min ECG recordings at randomization and 8, 16 and 24 weeks. HRV was determined by fast Fourier transform and autoregressive modelling. Results. Heart rate decreased by 9.5 beats/min in R patients with no change in E patients (− 2.2 beats/min). R patients had reduced total (− 0.13 ms²; p = 0.0038) and low-frequency power (− 3.6 nu; p = 0.057), higher high-frequency (+ 3.3 nu; p = 0.050) and a reduced low- to high-frequency ratio (− 0.08; p = 0.040). With adjustment for heart rate, these differences disappeared, except for the reduced low-frequency power in the R group (− 4.67 nu; p = 0.02). Analyses confined to 39 R and 47 E patients with HRV measurements at all visits or based on autoregressive modelling were confirmatory. Conclusion. In native black African patients, antihypertensive drugs modulate HRV, an index of autonomous nervous tone. However, these effects were mediated by changes in heart rate except for low-frequency variability, which was reduced on beta blockade independent of heart rate.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>24066715</pmid><doi>10.3109/08037051.2013.836810</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Africa South of the Sahara Antihypertensive Agents - therapeutic use Antihypertensive drugs blacks Cohort Studies Female Heart Rate - drug effects heart rate variability Humans Hypertension - drug therapy Hypertension - physiopathology Male Middle Aged Original randomized clinical trial sub-Saharan Africa |
| title | Heart rate variability on antihypertensive drugs in black patients living in sub-Saharan Africa |
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