Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab

Monoclonal antibody preparations have demonstrated considerable clinical utility in the treatment of specific malignancies, as well as inflammatory and infectious diseases. Antibodies are conventionally delivered by passive administration, typically requiring costly large-scale laboratory developmen...

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Veröffentlicht in:	Human vaccines & immunotherapeutics 2013-10, Vol.9 (10), p.2253-2262
Hauptverfasser:	Muthumani, Kar, Flingai, Seleeke, Wise, Megan, Tingey, Colleen, Ugen, Kenneth E, Weiner, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - blood Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Biological Therapy - methods DNA vaccine electroporation env Gene Products, Human Immunodeficiency Virus - immunology Female HIV Antibodies - blood HIV Antibodies - genetics HIV Antibodies - immunology HIV Antibodies - metabolism HIV Infections - therapy HIV-1 - immunology HIV-1 neutralization Immunoglobulin Fab Fragments - blood Immunoglobulin Fab Fragments - genetics Immunoglobulin Fab Fragments - immunology Immunoglobulin Fab Fragments - metabolism Mice Mice, Inbred BALB C monoclonal antibodies Plasmids - administration & dosage Recombinant Proteins - blood Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - metabolism Research Paper VRC01 mAb
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