Stimulation of sigma receptors with afobazole blocks activation of microglia and reduces toxicity caused by amyloid-β25-35

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of senile dementia in the United States. Accumulation of amyloid-β (Aβ) and the effects of this peptide on microglial cells contribute greatly to the etiology of AD. Experiments were carried out to determi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2013-11, Vol.347 (2), p.458
Hauptverfasser:	Behensky, Adam A, Yasny, Ilya E, Shuster, Alexander M, Seredenin, Sergei B, Petrov, Andrey V, Cuevas, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Amyloid beta-Peptides - toxicity Animals Animals, Newborn Apoptosis Regulatory Proteins - biosynthesis Benzimidazoles - pharmacology Calcium - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - pathology Cell Movement - drug effects Cell Survival - drug effects Cells, Cultured Female Immunohistochemistry Male Microglia - drug effects Microglia - metabolism Microglia - pathology Morpholines - pharmacology Peptide Fragments - toxicity Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Receptors, sigma - agonists Receptors, sigma - antagonists & inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!