A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?
Summary Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D 3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls. Introduction This stu...
Gespeichert in:
| Veröffentlicht in: | Osteoporosis international 2014, Vol.25 (1), p.305-315 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 315 |
|---|---|
| container_issue | 1 |
| container_start_page | 305 |
| container_title | Osteoporosis international |
| container_volume | 25 |
| creator | Wood, A. D. Secombes, K. R. Thies, F. Aucott, L. S. Black, A. J. Reid, D. M. Mavroeidi, A. Simpson, W. G. Fraser, W. D. Macdonald, H. M. |
| description | Summary
Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D
3
supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.
Introduction
This study aimed to test the supplementation effects of vitamin D
3
on physical function and examine associations between overweight/obesity and the biochemical response to treatment.
Methods
In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude—57° N) aged 60–70 years (body mass index (BMI), 18–45 kg/m
2
) were assigned (computer randomisation) to daily vitamin D
3
(400 I.U. (
n
= 102)/1,000 I.U. (
n
= 101)) or matching placebo (
n
= 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis.
Results
Treatment had no effect on grip strength (mean change (SD)/year = −0.5 (2.5), −0.9 (2.7) and −0.4 (3.3) kg force for 400/1,000 I.U. vitamin D
3
and placebo groups, respectively (
P
= .10, ANOVA)) or falls (
P
= .65, chi-squared test). Biochemical responses were similar across BMI categories ( |
| doi_str_mv | 10.1007/s00198-013-2473-8 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_sprin</sourceid><recordid>TN_cdi_pubmed_primary_23982800</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>23982800</sourcerecordid><originalsourceid>FETCH-LOGICAL-p998-48be4422b1433cadec7d3b2aeab80bf549e8dd3510d7ab3a4b43405856d3b66c3</originalsourceid><addsrcrecordid>eNo1Uctu2zAQJIoEjZv2A3op9gfUUiJlkb0EgfsKECBA4ENuBCmubAYSKZBUAn9K_jZ0nZwWuzP7mB1Cvtb0e01p9yNRWktR0ZpVDe9YJT6QVc1ZyeS6PSMrKllXSV4_XJBPKT3S0iNl95FcNEyKRlC6Ii_XMOuoxxFH2MWwzGDDYkaszOi8hfvNFsIATy7ryXn4xUCnhCk5v4N5f0iu1yMMi--zC_4nuAR5j2Bc6Pc4_Qcjpjn4hJAD5Ig6T-gz6GHAPqMFc4DwhPEZ3W5fymVlMJhcPlx9JueDHhN-eYuXZPvn93bzr7q9-3uzub6tZlm0c2GQ86YxR929tth3lplGozaCmqHlEoW1rK2p7bRhmhvOOG1Fuy609bpnl-Tbaey8mAmtmqObdDyo9xcVQnMipAL5HUb1GJboy0mqpurogzr5oIoP6uiDEuwV6PN8AQ</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Wood, A. D. ; Secombes, K. R. ; Thies, F. ; Aucott, L. S. ; Black, A. J. ; Reid, D. M. ; Mavroeidi, A. ; Simpson, W. G. ; Fraser, W. D. ; Macdonald, H. M.</creator><creatorcontrib>Wood, A. D. ; Secombes, K. R. ; Thies, F. ; Aucott, L. S. ; Black, A. J. ; Reid, D. M. ; Mavroeidi, A. ; Simpson, W. G. ; Fraser, W. D. ; Macdonald, H. M.</creatorcontrib><description>Summary
Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D
3
supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.
Introduction
This study aimed to test the supplementation effects of vitamin D
3
on physical function and examine associations between overweight/obesity and the biochemical response to treatment.
Methods
In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude—57° N) aged 60–70 years (body mass index (BMI), 18–45 kg/m
2
) were assigned (computer randomisation) to daily vitamin D
3
(400 I.U. (
n
= 102)/1,000 I.U. (
n
= 101)) or matching placebo (
n
= 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis.
Results
Treatment had no effect on grip strength (mean change (SD)/year = −0.5 (2.5), −0.9 (2.7) and −0.4 (3.3) kg force for 400/1,000 I.U. vitamin D
3
and placebo groups, respectively (
P
= .10, ANOVA)) or falls (
P
= .65, chi-squared test). Biochemical responses were similar across BMI categories (<25.25–29.99, ≥30 kg/m
2
) with the exception of a small change at 12-months in serum ACa in overweight compared to non-overweight participants (
P
= .01, ANOVA; 1,000 I.U. group). In the placebo group, 25(OH)D peak concentration change (winter to summer) was negatively associated with weight (
r
= −.268), BMI (
r
= −.198), total (
r
= −.278) and trunk fat mass (
r
= −.251), with total and trunk fat mass predictive of winter to summer 25(OH)D change (
P
= .01/.004 respectively, linear regression).
Conclusion
We found no evidence of an improvement in physical function following vitamin D
3
supplementation for 1 year.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-013-2473-8</identifier><identifier>PMID: 23982800</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Accidental Falls - prevention & control ; Aged ; Anthropometry - methods ; Body Composition ; Body Mass Index ; Calcium - blood ; Cholecalciferol - administration & dosage ; Cholecalciferol - therapeutic use ; Diet ; Dietary Supplements ; Dose-Response Relationship, Drug ; Double-Blind Method ; Endocrinology ; Female ; Hand Strength - physiology ; Humans ; Medicine ; Medicine & Public Health ; Middle Aged ; Motor Activity - drug effects ; Obesity - blood ; Obesity - physiopathology ; Original Article ; Orthopedics ; Overweight - blood ; Overweight - physiopathology ; Phosphates - blood ; Rheumatology ; Sunlight ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Osteoporosis international, 2014, Vol.25 (1), p.305-315</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p998-48be4422b1433cadec7d3b2aeab80bf549e8dd3510d7ab3a4b43405856d3b66c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-013-2473-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-013-2473-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23982800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wood, A. D.</creatorcontrib><creatorcontrib>Secombes, K. R.</creatorcontrib><creatorcontrib>Thies, F.</creatorcontrib><creatorcontrib>Aucott, L. S.</creatorcontrib><creatorcontrib>Black, A. J.</creatorcontrib><creatorcontrib>Reid, D. M.</creatorcontrib><creatorcontrib>Mavroeidi, A.</creatorcontrib><creatorcontrib>Simpson, W. G.</creatorcontrib><creatorcontrib>Fraser, W. D.</creatorcontrib><creatorcontrib>Macdonald, H. M.</creatorcontrib><title>A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D
3
supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.
Introduction
This study aimed to test the supplementation effects of vitamin D
3
on physical function and examine associations between overweight/obesity and the biochemical response to treatment.
Methods
In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude—57° N) aged 60–70 years (body mass index (BMI), 18–45 kg/m
2
) were assigned (computer randomisation) to daily vitamin D
3
(400 I.U. (
n
= 102)/1,000 I.U. (
n
= 101)) or matching placebo (
n
= 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis.
Results
Treatment had no effect on grip strength (mean change (SD)/year = −0.5 (2.5), −0.9 (2.7) and −0.4 (3.3) kg force for 400/1,000 I.U. vitamin D
3
and placebo groups, respectively (
P
= .10, ANOVA)) or falls (
P
= .65, chi-squared test). Biochemical responses were similar across BMI categories (<25.25–29.99, ≥30 kg/m
2
) with the exception of a small change at 12-months in serum ACa in overweight compared to non-overweight participants (
P
= .01, ANOVA; 1,000 I.U. group). In the placebo group, 25(OH)D peak concentration change (winter to summer) was negatively associated with weight (
r
= −.268), BMI (
r
= −.198), total (
r
= −.278) and trunk fat mass (
r
= −.251), with total and trunk fat mass predictive of winter to summer 25(OH)D change (
P
= .01/.004 respectively, linear regression).
Conclusion
We found no evidence of an improvement in physical function following vitamin D
3
supplementation for 1 year.</description><subject>Accidental Falls - prevention & control</subject><subject>Aged</subject><subject>Anthropometry - methods</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Calcium - blood</subject><subject>Cholecalciferol - administration & dosage</subject><subject>Cholecalciferol - therapeutic use</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Hand Strength - physiology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Motor Activity - drug effects</subject><subject>Obesity - blood</subject><subject>Obesity - physiopathology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Overweight - blood</subject><subject>Overweight - physiopathology</subject><subject>Phosphates - blood</subject><subject>Rheumatology</subject><subject>Sunlight</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1Uctu2zAQJIoEjZv2A3op9gfUUiJlkb0EgfsKECBA4ENuBCmubAYSKZBUAn9K_jZ0nZwWuzP7mB1Cvtb0e01p9yNRWktR0ZpVDe9YJT6QVc1ZyeS6PSMrKllXSV4_XJBPKT3S0iNl95FcNEyKRlC6Ii_XMOuoxxFH2MWwzGDDYkaszOi8hfvNFsIATy7ryXn4xUCnhCk5v4N5f0iu1yMMi--zC_4nuAR5j2Bc6Pc4_Qcjpjn4hJAD5Ig6T-gz6GHAPqMFc4DwhPEZ3W5fymVlMJhcPlx9JueDHhN-eYuXZPvn93bzr7q9-3uzub6tZlm0c2GQ86YxR929tth3lplGozaCmqHlEoW1rK2p7bRhmhvOOG1Fuy609bpnl-Tbaey8mAmtmqObdDyo9xcVQnMipAL5HUb1GJboy0mqpurogzr5oIoP6uiDEuwV6PN8AQ</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Wood, A. D.</creator><creator>Secombes, K. R.</creator><creator>Thies, F.</creator><creator>Aucott, L. S.</creator><creator>Black, A. J.</creator><creator>Reid, D. M.</creator><creator>Mavroeidi, A.</creator><creator>Simpson, W. G.</creator><creator>Fraser, W. D.</creator><creator>Macdonald, H. M.</creator><general>Springer London</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>2014</creationdate><title>A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?</title><author>Wood, A. D. ; Secombes, K. R. ; Thies, F. ; Aucott, L. S. ; Black, A. J. ; Reid, D. M. ; Mavroeidi, A. ; Simpson, W. G. ; Fraser, W. D. ; Macdonald, H. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p998-48be4422b1433cadec7d3b2aeab80bf549e8dd3510d7ab3a4b43405856d3b66c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Accidental Falls - prevention & control</topic><topic>Aged</topic><topic>Anthropometry - methods</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Calcium - blood</topic><topic>Cholecalciferol - administration & dosage</topic><topic>Cholecalciferol - therapeutic use</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Hand Strength - physiology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Motor Activity - drug effects</topic><topic>Obesity - blood</topic><topic>Obesity - physiopathology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Overweight - blood</topic><topic>Overweight - physiopathology</topic><topic>Phosphates - blood</topic><topic>Rheumatology</topic><topic>Sunlight</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, A. D.</creatorcontrib><creatorcontrib>Secombes, K. R.</creatorcontrib><creatorcontrib>Thies, F.</creatorcontrib><creatorcontrib>Aucott, L. S.</creatorcontrib><creatorcontrib>Black, A. J.</creatorcontrib><creatorcontrib>Reid, D. M.</creatorcontrib><creatorcontrib>Mavroeidi, A.</creatorcontrib><creatorcontrib>Simpson, W. G.</creatorcontrib><creatorcontrib>Fraser, W. D.</creatorcontrib><creatorcontrib>Macdonald, H. M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, A. D.</au><au>Secombes, K. R.</au><au>Thies, F.</au><au>Aucott, L. S.</au><au>Black, A. J.</au><au>Reid, D. M.</au><au>Mavroeidi, A.</au><au>Simpson, W. G.</au><au>Fraser, W. D.</au><au>Macdonald, H. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity?</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2014</date><risdate>2014</risdate><volume>25</volume><issue>1</issue><spage>305</spage><epage>315</epage><pages>305-315</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D
3
supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.
Introduction
This study aimed to test the supplementation effects of vitamin D
3
on physical function and examine associations between overweight/obesity and the biochemical response to treatment.
Methods
In a parallel group double-blind RCT, healthy postmenopausal women from North East Scotland (latitude—57° N) aged 60–70 years (body mass index (BMI), 18–45 kg/m
2
) were assigned (computer randomisation) to daily vitamin D
3
(400 I.U. (
n
= 102)/1,000 I.U. (
n
= 101)) or matching placebo (
n
= 102) (97, 96 and 100 participants analysed for outcomes, respectively) from identical coded containers for 1 year. Grip strength (primary outcome), falls, diet, physical activity and ultraviolet B radiation exposure were measured bimonthly, as were serum 25(OH)D, adjusted calcium (ACa) and phosphate. Fat/lean mass (dual energy X-ray absorptiometry), anthropometry, 1,25-dihydroxyvitamin D and parathyroid hormone were measured at baseline and 12 months. Participants and researchers were blinded throughout intervention and analysis.
Results
Treatment had no effect on grip strength (mean change (SD)/year = −0.5 (2.5), −0.9 (2.7) and −0.4 (3.3) kg force for 400/1,000 I.U. vitamin D
3
and placebo groups, respectively (
P
= .10, ANOVA)) or falls (
P
= .65, chi-squared test). Biochemical responses were similar across BMI categories (<25.25–29.99, ≥30 kg/m
2
) with the exception of a small change at 12-months in serum ACa in overweight compared to non-overweight participants (
P
= .01, ANOVA; 1,000 I.U. group). In the placebo group, 25(OH)D peak concentration change (winter to summer) was negatively associated with weight (
r
= −.268), BMI (
r
= −.198), total (
r
= −.278) and trunk fat mass (
r
= −.251), with total and trunk fat mass predictive of winter to summer 25(OH)D change (
P
= .01/.004 respectively, linear regression).
Conclusion
We found no evidence of an improvement in physical function following vitamin D
3
supplementation for 1 year.</abstract><cop>London</cop><pub>Springer London</pub><pmid>23982800</pmid><doi>10.1007/s00198-013-2473-8</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-941X |
| ispartof | Osteoporosis international, 2014, Vol.25 (1), p.305-315 |
| issn | 0937-941X 1433-2965 |
| language | eng |
| recordid | cdi_pubmed_primary_23982800 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Accidental Falls - prevention & control Aged Anthropometry - methods Body Composition Body Mass Index Calcium - blood Cholecalciferol - administration & dosage Cholecalciferol - therapeutic use Diet Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Endocrinology Female Hand Strength - physiology Humans Medicine Medicine & Public Health Middle Aged Motor Activity - drug effects Obesity - blood Obesity - physiopathology Original Article Orthopedics Overweight - blood Overweight - physiopathology Phosphates - blood Rheumatology Sunlight Vitamin D - analogs & derivatives Vitamin D - blood |
| title | A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T21%3A45%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_sprin&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20parallel%20group%20double-blind%20RCT%20of%20vitamin%20D3%20assessing%20physical%20function:%20is%20the%20biochemical%20response%20to%20treatment%20affected%20by%20overweight%20and%20obesity?&rft.jtitle=Osteoporosis%20international&rft.au=Wood,%20A.%20D.&rft.date=2014&rft.volume=25&rft.issue=1&rft.spage=305&rft.epage=315&rft.pages=305-315&rft.issn=0937-941X&rft.eissn=1433-2965&rft_id=info:doi/10.1007/s00198-013-2473-8&rft_dat=%3Cpubmed_sprin%3E23982800%3C/pubmed_sprin%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/23982800&rfr_iscdi=true |