The relationship between atherogenic index of plasma and epicardial adipose tissue in hemodialysis and peritoneal dialysis patients
Abstract Introduction: Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT was shown in end-stage renal disease (ESRD) patients. One of the established risk factor in this population is dyslipidemia. We aimed to determ...
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| Veröffentlicht in: | Renal failure 2013-10, Vol.35 (9), p.1193-1198 |
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| creator | Erdur, Mehmet Fatih Tonbul, Halil Zeki Ozbiner, Huseyin Ozcicek, Adalet Ozcicek, Fatih Akbas, Emin Murat Ozbek, Orhan Hamur, Hikmet Turkmen, Kultigin |
| description | Abstract
Introduction: Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT was shown in end-stage renal disease (ESRD) patients. One of the established risk factor in this population is dyslipidemia. We aimed to determine the relationship between atherogenic index of plasma (AIP) and EAT in ESRD patients. Methods: This was a cross-sectional study involving 76 ESRD patients receiving PD or HD for 6 months and 42 healthy subjects. EAT was measured by using an electrocardiogram-gated 64-multidetector computed tomography (MDCT). Atherogenic index of plasma was calculated as the logarithmically transformed ratio of the serum trigliseride to HDL-cholesterol. Results: The etiology of ESRD patients was diabetic nephropathy (n = 16), chronic glomerulonephritis (n = 10), hypertensive nephropathy (n = 23), polycystic kidney disease (n = 7), nephrolithiasis (n = 5) and unknown (n = 15). There were no differences with respect to the following variables between ESRD patients and healthy subjects: age; sex; BMI; predialysis levels of DBP; serum levels of albumin, HDL-cholesterol and hemoglobin. However, ESRD patients had higher serum levels of trigliseride, hs-CRP and AIP when compared to healthy subjects. There was a statistically significant relationship between EAT, BMI and AIP in ESRD patients (r = 0.42, p |
| doi_str_mv | 10.3109/0886022X.2013.823826 |
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Introduction: Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT was shown in end-stage renal disease (ESRD) patients. One of the established risk factor in this population is dyslipidemia. We aimed to determine the relationship between atherogenic index of plasma (AIP) and EAT in ESRD patients. Methods: This was a cross-sectional study involving 76 ESRD patients receiving PD or HD for 6 months and 42 healthy subjects. EAT was measured by using an electrocardiogram-gated 64-multidetector computed tomography (MDCT). Atherogenic index of plasma was calculated as the logarithmically transformed ratio of the serum trigliseride to HDL-cholesterol. Results: The etiology of ESRD patients was diabetic nephropathy (n = 16), chronic glomerulonephritis (n = 10), hypertensive nephropathy (n = 23), polycystic kidney disease (n = 7), nephrolithiasis (n = 5) and unknown (n = 15). There were no differences with respect to the following variables between ESRD patients and healthy subjects: age; sex; BMI; predialysis levels of DBP; serum levels of albumin, HDL-cholesterol and hemoglobin. However, ESRD patients had higher serum levels of trigliseride, hs-CRP and AIP when compared to healthy subjects. There was a statistically significant relationship between EAT, BMI and AIP in ESRD patients (r = 0.42, p < 0.001 and r = 0.25, p = 0.028, respectively). The stepwise linear regression analysis revealed that age, as well as BMI were independent predictors of EAT. Conclusion: We found a relationship between EAT as defined by MDCT and AIP in ESRD patients. Further clinical and experimental studies are needed.</description><identifier>ISSN: 0886-022X</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.3109/0886022X.2013.823826</identifier><identifier>PMID: 23924265</identifier><language>eng</language><publisher>England: Informa Healthcare USA, Inc</publisher><subject>Adipose Tissue - diagnostic imaging ; Adiposity ; Adult ; Atherogenic index of plasma ; Case-Control Studies ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; end-stage renal disease ; epicardial adipose tissue ; Female ; high density lipoprotein ; Humans ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - diagnostic imaging ; Male ; Middle Aged ; Radiography ; triglyceride ; Triglycerides - blood</subject><ispartof>Renal failure, 2013-10, Vol.35 (9), p.1193-1198</ispartof><rights>2013 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-30cf6a77774304538d837bd0664ee3a3c751208145b84c4fec1e0ee1de299c3e3</citedby><cites>FETCH-LOGICAL-c530t-30cf6a77774304538d837bd0664ee3a3c751208145b84c4fec1e0ee1de299c3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23924265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erdur, Mehmet Fatih</creatorcontrib><creatorcontrib>Tonbul, Halil Zeki</creatorcontrib><creatorcontrib>Ozbiner, Huseyin</creatorcontrib><creatorcontrib>Ozcicek, Adalet</creatorcontrib><creatorcontrib>Ozcicek, Fatih</creatorcontrib><creatorcontrib>Akbas, Emin Murat</creatorcontrib><creatorcontrib>Ozbek, Orhan</creatorcontrib><creatorcontrib>Hamur, Hikmet</creatorcontrib><creatorcontrib>Turkmen, Kultigin</creatorcontrib><title>The relationship between atherogenic index of plasma and epicardial adipose tissue in hemodialysis and peritoneal dialysis patients</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description>Abstract
Introduction: Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT was shown in end-stage renal disease (ESRD) patients. One of the established risk factor in this population is dyslipidemia. We aimed to determine the relationship between atherogenic index of plasma (AIP) and EAT in ESRD patients. Methods: This was a cross-sectional study involving 76 ESRD patients receiving PD or HD for 6 months and 42 healthy subjects. EAT was measured by using an electrocardiogram-gated 64-multidetector computed tomography (MDCT). Atherogenic index of plasma was calculated as the logarithmically transformed ratio of the serum trigliseride to HDL-cholesterol. Results: The etiology of ESRD patients was diabetic nephropathy (n = 16), chronic glomerulonephritis (n = 10), hypertensive nephropathy (n = 23), polycystic kidney disease (n = 7), nephrolithiasis (n = 5) and unknown (n = 15). There were no differences with respect to the following variables between ESRD patients and healthy subjects: age; sex; BMI; predialysis levels of DBP; serum levels of albumin, HDL-cholesterol and hemoglobin. However, ESRD patients had higher serum levels of trigliseride, hs-CRP and AIP when compared to healthy subjects. There was a statistically significant relationship between EAT, BMI and AIP in ESRD patients (r = 0.42, p < 0.001 and r = 0.25, p = 0.028, respectively). The stepwise linear regression analysis revealed that age, as well as BMI were independent predictors of EAT. Conclusion: We found a relationship between EAT as defined by MDCT and AIP in ESRD patients. Further clinical and experimental studies are needed.</description><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adiposity</subject><subject>Adult</subject><subject>Atherogenic index of plasma</subject><subject>Case-Control Studies</subject><subject>Cholesterol, HDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>end-stage renal disease</subject><subject>epicardial adipose tissue</subject><subject>Female</subject><subject>high density lipoprotein</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - diagnostic imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiography</subject><subject>triglyceride</subject><subject>Triglycerides - blood</subject><issn>0886-022X</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3DAURkVJaaZp36AULbPxRH-25U1KCU1bCHSTQndCI13XCrbkSDLJrPvikTNJoJtoI5DO_T5xhNAnSracku6MSNkQxv5sGaF8KxmXrHmDNrRmddUQ0R2hzYpUK3OM3qd0QwitZcveoWPGOyZYU2_Qv-sBcIRRZxd8GtyMd5DvADzWeYAY_oJ3Bjtv4R6HHs-jTpPG2lsMszM6WqdHrK2bQwKcXUoLFBoPMIX1ap9ceqRniC4HD4V-OZ9LKficPqC3vR4TfHzaT9Dvy2_XFz-qq1_ff158vapMzUmuODF9o9uyBCei5tJK3u4saRoBwDU3bU0ZkVTUOymM6MFQIADUAus6w4GfoNND7hzD7QIpq8klA-OoPYQlKSo4I63oWlZQcUBNDClF6NUc3aTjXlGiVv3qWb9a9auD_jL2-alh2U1gX4aefRfgywFwvg9x0nchjlZlvR9D7KP2xqU1_tWK8_8ShqI0D-UnQN2EJfoi8PU3PgBPu6q3</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Erdur, Mehmet Fatih</creator><creator>Tonbul, Halil Zeki</creator><creator>Ozbiner, Huseyin</creator><creator>Ozcicek, Adalet</creator><creator>Ozcicek, Fatih</creator><creator>Akbas, Emin Murat</creator><creator>Ozbek, Orhan</creator><creator>Hamur, Hikmet</creator><creator>Turkmen, Kultigin</creator><general>Informa Healthcare USA, Inc</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>The relationship between atherogenic index of plasma and epicardial adipose tissue in hemodialysis and peritoneal dialysis patients</title><author>Erdur, Mehmet Fatih ; Tonbul, Halil Zeki ; Ozbiner, Huseyin ; Ozcicek, Adalet ; Ozcicek, Fatih ; Akbas, Emin Murat ; Ozbek, Orhan ; Hamur, Hikmet ; Turkmen, Kultigin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-30cf6a77774304538d837bd0664ee3a3c751208145b84c4fec1e0ee1de299c3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adiposity</topic><topic>Adult</topic><topic>Atherogenic index of plasma</topic><topic>Case-Control Studies</topic><topic>Cholesterol, HDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>end-stage renal disease</topic><topic>epicardial adipose tissue</topic><topic>Female</topic><topic>high density lipoprotein</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - diagnostic imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radiography</topic><topic>triglyceride</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erdur, Mehmet Fatih</creatorcontrib><creatorcontrib>Tonbul, Halil Zeki</creatorcontrib><creatorcontrib>Ozbiner, Huseyin</creatorcontrib><creatorcontrib>Ozcicek, Adalet</creatorcontrib><creatorcontrib>Ozcicek, Fatih</creatorcontrib><creatorcontrib>Akbas, Emin Murat</creatorcontrib><creatorcontrib>Ozbek, Orhan</creatorcontrib><creatorcontrib>Hamur, Hikmet</creatorcontrib><creatorcontrib>Turkmen, Kultigin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdur, Mehmet Fatih</au><au>Tonbul, Halil Zeki</au><au>Ozbiner, Huseyin</au><au>Ozcicek, Adalet</au><au>Ozcicek, Fatih</au><au>Akbas, Emin Murat</au><au>Ozbek, Orhan</au><au>Hamur, Hikmet</au><au>Turkmen, Kultigin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between atherogenic index of plasma and epicardial adipose tissue in hemodialysis and peritoneal dialysis patients</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>2013-10</date><risdate>2013</risdate><volume>35</volume><issue>9</issue><spage>1193</spage><epage>1198</epage><pages>1193-1198</pages><issn>0886-022X</issn><eissn>1525-6049</eissn><abstract>Abstract
Introduction: Epicardial adipose tissue (EAT) is the true visceral fat depot of the heart. The relationship between coronary artery disease and EAT was shown in end-stage renal disease (ESRD) patients. One of the established risk factor in this population is dyslipidemia. We aimed to determine the relationship between atherogenic index of plasma (AIP) and EAT in ESRD patients. Methods: This was a cross-sectional study involving 76 ESRD patients receiving PD or HD for 6 months and 42 healthy subjects. EAT was measured by using an electrocardiogram-gated 64-multidetector computed tomography (MDCT). Atherogenic index of plasma was calculated as the logarithmically transformed ratio of the serum trigliseride to HDL-cholesterol. Results: The etiology of ESRD patients was diabetic nephropathy (n = 16), chronic glomerulonephritis (n = 10), hypertensive nephropathy (n = 23), polycystic kidney disease (n = 7), nephrolithiasis (n = 5) and unknown (n = 15). There were no differences with respect to the following variables between ESRD patients and healthy subjects: age; sex; BMI; predialysis levels of DBP; serum levels of albumin, HDL-cholesterol and hemoglobin. However, ESRD patients had higher serum levels of trigliseride, hs-CRP and AIP when compared to healthy subjects. There was a statistically significant relationship between EAT, BMI and AIP in ESRD patients (r = 0.42, p < 0.001 and r = 0.25, p = 0.028, respectively). The stepwise linear regression analysis revealed that age, as well as BMI were independent predictors of EAT. Conclusion: We found a relationship between EAT as defined by MDCT and AIP in ESRD patients. Further clinical and experimental studies are needed.</abstract><cop>England</cop><pub>Informa Healthcare USA, Inc</pub><pmid>23924265</pmid><doi>10.3109/0886022X.2013.823826</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue - diagnostic imaging Adiposity Adult Atherogenic index of plasma Case-Control Studies Cholesterol, HDL - blood Cross-Sectional Studies end-stage renal disease epicardial adipose tissue Female high density lipoprotein Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - diagnostic imaging Male Middle Aged Radiography triglyceride Triglycerides - blood |
| title | The relationship between atherogenic index of plasma and epicardial adipose tissue in hemodialysis and peritoneal dialysis patients |
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