4,5-dianilinophtalimide protects neuroendocrine cells against serum deprivation-induced stress and apoptosis

The aim of this study was to reveal the effects of 4,5-dianilinophthalimide (DAPH), which inhibits amyloid β fibrillization, against serum deprivation (SD)-induced apoptosis and the possible mechanisms in differentiated PC12 neuron cells. Firstly, we evaluated whether DAPH protects cell viability ex...

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Veröffentlicht in:	Neuro-endocrinology letters 2013, Vol.34 (5), p.359
Hauptverfasser:	Ergin, Volkan, Erdogan, Mutlu, Karasu, Cimen, Menevse, Adnan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Caspase 3 - metabolism Cell Survival - drug effects HSP27 Heat-Shock Proteins - metabolism Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology p38 Mitogen-Activated Protein Kinases - metabolism PC12 Cells Phosphorylation - drug effects Phthalimides - pharmacology Proto-Oncogene Proteins c-jun - metabolism Rats Reactive Oxygen Species - metabolism Stress, Physiological - drug effects Up-Regulation - drug effects
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