DENV-2 subunit proteins fused to CR2 receptor-binding domain (P28)-induces specific and neutralizing antibodies to the Dengue virus in mice

Domain III (DIII) of the dengue virus (DENV) envelope (E) protein induces strong neutralizing type-specific antibodies. In addition, a region near the fusion loop in domain II (DII) induces the production of cross-reactive antibodies with neutralizing potential. Thus, this study aimed to generate DE...

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Veröffentlicht in:	Human vaccines & immunotherapeutics 2013-11, Vol.9 (11), p.2326-2335
Hauptverfasser:	García-Machorro, Jazmín, López-González, Moisés, Barrios-Rojas, Olivia, Fernández-Pomares, Cynthia, Sandoval-Montes, Claudia, Santos-Argumedo, Leopoldo, Villegas-Sepúlveda, Nicolás, Gutiérrez-Castañeda, Benito, Cedillo-Barrón, Leticia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Cell Line Complement C3d - genetics Complement C3d - metabolism dengue enveloped protein Domain II and III Dengue Vaccines - administration & dosage Dengue Vaccines - genetics Dengue Vaccines - immunology Dengue Virus - genetics Dengue Virus - immunology Dengue Virus - metabolism Drosophila melanogaster Enzyme-Linked Immunosorbent Assay Female Humans immunization Male Mice, Inbred BALB C Neutralization Tests Protein Binding Receptors, Complement - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - metabolism recombinant proteins Research Paper Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Envelope Proteins - metabolism
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