Development and characterization of LTA-appended chitosan nanoparticles for mucosal immunization against hepatitis B

Abstract The present study was aimed at exploring the targeting potential of LTA-anchored chitosan nanoparticles (CH-NP) specifically to M cell following oral immunization. The lectinized CH-NP exhibited 7-29% coupling capacity depending upon the amount of glutaraldehyde added. Induction of the muco...

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Veröffentlicht in:	Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2014-08, Vol.42 (4), p.245-255
Hauptverfasser:	Mishra, Neeraj, Khatri, Kapil, Gupta, Madhu, Vyas, Suresh P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chitosan - chemistry chitosan nanoparticles Female Glutaral - chemistry hepatitis B Hepatitis B - prevention & control Hepatitis B Surface Antigens - immunology Hepatitis B Vaccines - chemistry Hepatitis B Vaccines - immunology Immunization - methods Lectins - chemistry LTA lectin M cells Mice Mucous Membrane - immunology Nanoparticles - chemistry oral immunization Peyer's Patches - cytology
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