A Case of systemic lupus erythematosus associated with cryptococcal meningitis which was successfully cured by the administration of massive dose of amphotericin B
A case of SLE with moderately deteriorated renal function due to lupus nephritis developed cryptococcal meningitis. Long term administration of amphotericin B (cumulative dose 5g) combined with 5-flucytosine eradicated this fungal infection. Throughout amphotericin B administration urinary excretion...
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| Veröffentlicht in: | Nihon Jinzo Gakkai shi 1990, Vol.32(4), pp.441-449 |
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| container_end_page | 449 |
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| container_issue | 4 |
| container_start_page | 441 |
| container_title | Nihon Jinzo Gakkai shi |
| container_volume | 32 |
| creator | MATSUDA, OSAMU HIRUMA, MASATARO MAKIGUCHI, KOHEI TSUTSUI, HIDEHITO CHIDA, YOSHIKO IDA, TAKASHI MALUMO, FUMIAKI |
| description | A case of SLE with moderately deteriorated renal function due to lupus nephritis developed cryptococcal meningitis. Long term administration of amphotericin B (cumulative dose 5g) combined with 5-flucytosine eradicated this fungal infection. Throughout amphotericin B administration urinary excretions of Na and K, as well as plasma HCO3 concentration were monitored, and, Na, K and HCO3 were supplemented orally and intravenously so much as to replace their urinary losses. Neither prominent water-electrolyte disturbace nor severe azotemia, which are the most serious side effects of amphotericin B, did not ensue. This case study indicates that sufficient water-electrolytes supplementation is im-portant to prevent the nephrotoxicity of amphotericin B. |
| doi_str_mv | 10.14842/jpnjnephrol1959.32.441 |
| format | Article |
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Long term administration of amphotericin B (cumulative dose 5g) combined with 5-flucytosine eradicated this fungal infection. Throughout amphotericin B administration urinary excretions of Na and K, as well as plasma HCO3 concentration were monitored, and, Na, K and HCO3 were supplemented orally and intravenously so much as to replace their urinary losses. Neither prominent water-electrolyte disturbace nor severe azotemia, which are the most serious side effects of amphotericin B, did not ensue. This case study indicates that sufficient water-electrolytes supplementation is im-portant to prevent the nephrotoxicity of amphotericin B.</description><identifier>ISSN: 0385-2385</identifier><identifier>EISSN: 1884-0728</identifier><identifier>DOI: 10.14842/jpnjnephrol1959.32.441</identifier><identifier>PMID: 2376914</identifier><language>jpn</language><publisher>Japan: Japanese Society of Nephrology</publisher><subject>Adult ; amphotericin B ; Amphotericin B - administration & dosage ; Amphotericin B - therapeutic use ; cryptococcal meningitis ; Cryptococcosis ; Drug Therapy, Combination ; flucytosine ; Flucytosine - administration & dosage ; Humans ; Infusions, Intravenous ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - drug therapy ; Meningitis - drug therapy ; Meningitis - etiology ; nephrotoxicity ; Prednisolone - adverse effects ; systemic lupus erythematosus ; water-electrolytes supplementation</subject><ispartof>The Japanese Journal of Nephrology, 1990, Vol.32(4), pp.441-449</ispartof><rights>Japanese Society of Nephrology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2376914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MATSUDA, OSAMU</creatorcontrib><creatorcontrib>HIRUMA, MASATARO</creatorcontrib><creatorcontrib>MAKIGUCHI, KOHEI</creatorcontrib><creatorcontrib>TSUTSUI, HIDEHITO</creatorcontrib><creatorcontrib>CHIDA, YOSHIKO</creatorcontrib><creatorcontrib>IDA, TAKASHI</creatorcontrib><creatorcontrib>MALUMO, FUMIAKI</creatorcontrib><title>A Case of systemic lupus erythematosus associated with cryptococcal meningitis which was successfully cured by the administration of massive dose of amphotericin B</title><title>Nihon Jinzo Gakkai shi</title><addtitle>Jpn J Nephrol</addtitle><description>A case of SLE with moderately deteriorated renal function due to lupus nephritis developed cryptococcal meningitis. Long term administration of amphotericin B (cumulative dose 5g) combined with 5-flucytosine eradicated this fungal infection. Throughout amphotericin B administration urinary excretions of Na and K, as well as plasma HCO3 concentration were monitored, and, Na, K and HCO3 were supplemented orally and intravenously so much as to replace their urinary losses. Neither prominent water-electrolyte disturbace nor severe azotemia, which are the most serious side effects of amphotericin B, did not ensue. This case study indicates that sufficient water-electrolytes supplementation is im-portant to prevent the nephrotoxicity of amphotericin B.</description><subject>Adult</subject><subject>amphotericin B</subject><subject>Amphotericin B - administration & dosage</subject><subject>Amphotericin B - therapeutic use</subject><subject>cryptococcal meningitis</subject><subject>Cryptococcosis</subject><subject>Drug Therapy, Combination</subject><subject>flucytosine</subject><subject>Flucytosine - administration & dosage</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - drug therapy</subject><subject>Meningitis - drug therapy</subject><subject>Meningitis - etiology</subject><subject>nephrotoxicity</subject><subject>Prednisolone - adverse effects</subject><subject>systemic lupus erythematosus</subject><subject>water-electrolytes supplementation</subject><issn>0385-2385</issn><issn>1884-0728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUcFq3DAQFSUlXbb5hFL9gLeWJVvSMV2atCSQS3I20ngUa7EtI8ld_D390bpsyKGXNwxv5r1hHiFfWXlgQonq22meThPOfQwD07U-8OogBPtAdkwpUZSyUldkV3JVF9UGn8hNSt6WTMmS11Jck-uKy0YzsSN_bunRJKTB0bSmjKMHOizzkijGNfc4mhzS1pmUAniTsaNnn3sKcZ1zgABgBjri5KdXn32i595DT88m0bQAYEpuGYaVwhK3TbvSTZKabvSTTzma7MP0z3rc5P1vpF24nGLGuQ8Zowc_0e-fyUdnhoQ3b3VPXu5-PB9_Fo9P97-Ot4_FiQkpCsDGlErVNbOu4yAtl0I3urHCKs0sKNG5DpytGtdoqR1zgFII3mjFdV1pvidfLrrzYkfs2jn60cS1fXvWxj9c-FPK5hXfeROzhwHb_1JpedWKC2zhvE9Bb2KLE_8L0SqQcg</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>MATSUDA, OSAMU</creator><creator>HIRUMA, MASATARO</creator><creator>MAKIGUCHI, KOHEI</creator><creator>TSUTSUI, HIDEHITO</creator><creator>CHIDA, YOSHIKO</creator><creator>IDA, TAKASHI</creator><creator>MALUMO, FUMIAKI</creator><general>Japanese Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>1990</creationdate><title>A Case of systemic lupus erythematosus associated with cryptococcal meningitis which was successfully cured by the administration of massive dose of amphotericin B</title><author>MATSUDA, OSAMU ; HIRUMA, MASATARO ; MAKIGUCHI, KOHEI ; TSUTSUI, HIDEHITO ; CHIDA, YOSHIKO ; IDA, TAKASHI ; MALUMO, FUMIAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1474-ce6a088551bfd3c7b3749696b4b891bc84dfdcfb26f6979f1fce7443698395293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1990</creationdate><topic>Adult</topic><topic>amphotericin B</topic><topic>Amphotericin B - administration & dosage</topic><topic>Amphotericin B - therapeutic use</topic><topic>cryptococcal meningitis</topic><topic>Cryptococcosis</topic><topic>Drug Therapy, Combination</topic><topic>flucytosine</topic><topic>Flucytosine - administration & dosage</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Meningitis - drug therapy</topic><topic>Meningitis - etiology</topic><topic>nephrotoxicity</topic><topic>Prednisolone - adverse effects</topic><topic>systemic lupus erythematosus</topic><topic>water-electrolytes supplementation</topic><toplevel>online_resources</toplevel><creatorcontrib>MATSUDA, OSAMU</creatorcontrib><creatorcontrib>HIRUMA, MASATARO</creatorcontrib><creatorcontrib>MAKIGUCHI, KOHEI</creatorcontrib><creatorcontrib>TSUTSUI, HIDEHITO</creatorcontrib><creatorcontrib>CHIDA, YOSHIKO</creatorcontrib><creatorcontrib>IDA, TAKASHI</creatorcontrib><creatorcontrib>MALUMO, FUMIAKI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nihon Jinzo Gakkai shi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MATSUDA, OSAMU</au><au>HIRUMA, MASATARO</au><au>MAKIGUCHI, KOHEI</au><au>TSUTSUI, HIDEHITO</au><au>CHIDA, YOSHIKO</au><au>IDA, TAKASHI</au><au>MALUMO, FUMIAKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Case of systemic lupus erythematosus associated with cryptococcal meningitis which was successfully cured by the administration of massive dose of amphotericin B</atitle><jtitle>Nihon Jinzo Gakkai shi</jtitle><addtitle>Jpn J Nephrol</addtitle><date>1990</date><risdate>1990</risdate><volume>32</volume><issue>4</issue><spage>441</spage><epage>449</epage><pages>441-449</pages><issn>0385-2385</issn><eissn>1884-0728</eissn><abstract>A case of SLE with moderately deteriorated renal function due to lupus nephritis developed cryptococcal meningitis. Long term administration of amphotericin B (cumulative dose 5g) combined with 5-flucytosine eradicated this fungal infection. Throughout amphotericin B administration urinary excretions of Na and K, as well as plasma HCO3 concentration were monitored, and, Na, K and HCO3 were supplemented orally and intravenously so much as to replace their urinary losses. Neither prominent water-electrolyte disturbace nor severe azotemia, which are the most serious side effects of amphotericin B, did not ensue. This case study indicates that sufficient water-electrolytes supplementation is im-portant to prevent the nephrotoxicity of amphotericin B.</abstract><cop>Japan</cop><pub>Japanese Society of Nephrology</pub><pmid>2376914</pmid><doi>10.14842/jpnjnephrol1959.32.441</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-2385 |
| ispartof | The Japanese Journal of Nephrology, 1990, Vol.32(4), pp.441-449 |
| issn | 0385-2385 1884-0728 |
| language | jpn |
| recordid | cdi_pubmed_primary_2376914 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult amphotericin B Amphotericin B - administration & dosage Amphotericin B - therapeutic use cryptococcal meningitis Cryptococcosis Drug Therapy, Combination flucytosine Flucytosine - administration & dosage Humans Infusions, Intravenous Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - drug therapy Meningitis - drug therapy Meningitis - etiology nephrotoxicity Prednisolone - adverse effects systemic lupus erythematosus water-electrolytes supplementation |
| title | A Case of systemic lupus erythematosus associated with cryptococcal meningitis which was successfully cured by the administration of massive dose of amphotericin B |
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