Emodin induces cytotoxic effect in human breast carcinoma MCF-7 cell through modulating the expression of apoptosis-related genes

Abstract Context: The poor prognostic outcome of breast cancer is largely due to its resistance to cancer therapies. Development of therapeutic agents that can inhibit growth and induce apoptosis in breast cancer cells can help solve the problem. Emodin is an active anthraquinone that has been repor...

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Veröffentlicht in:	Pharmaceutical biology 2013-09, Vol.51 (9), p.1175-1181
Hauptverfasser:	Li, Wing-Yan, Chan, Robbie Yat-Kan, Yu, Peter Hoi-Fu, Chan, Shun-Wan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinone Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Breast Neoplasms - drug therapy Carcinoma - drug therapy Cathartics - pharmacology cell cycle arrest Cell Proliferation - drug effects Cyclin D1 - antagonists & inhibitors Cyclin D1 - genetics Cyclin D1 - metabolism DNA Breaks, Single-Stranded - drug effects DNA Fragmentation Emodin - pharmacology Fas Ligand Protein - biosynthesis Fas Ligand Protein - genetics Fas Ligand Protein - metabolism Female Gene Expression Regulation, Neoplastic - drug effects growth inhibition Humans Inhibitory Concentration 50 MCF-7 Cells Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors Myeloid Cell Leukemia Sequence 1 Protein - metabolism Neoplastic Stem Cells - drug effects programmed cell death Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism
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