Proton beam radiotherapy: report of the first patient treated at the Centro Nazionale di Adroterapia Oncologica (CNAO) [National Center of Oncologic Hadron Therapy]
Proton beam radiotherapy, an innovative treatment modality, allows delivery of high radiation doses to the target while sparing surrounding healthy structures. The Centro Nazionale di Adroterapia Oncologica (CNAO), equipped with a synchrotron and capable of using both protons and ions, initiated its...
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| Veröffentlicht in: | Tumori 2013-03, Vol.99 (2), p.e34 |
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| creator | Orecchia, Roberto Srivastava, Anurita Fiore, Maria Rosaria Vitolo, Viviana Fossati, Piero Vischioni, Barbara Iannalfi, Alberto Tuan, Jeffrey Ciocca, Mario Molinelli, Silvia Mirandola, Alfredo Vilches, Gloria Mairani, Andrea Tagaste, Barbara Baroni, Guido Rossi, Sandro Krengli, Marco |
| description | Proton beam radiotherapy, an innovative treatment modality, allows delivery of high radiation doses to the target while sparing surrounding healthy structures. The Centro Nazionale di Adroterapia Oncologica (CNAO), equipped with a synchrotron and capable of using both protons and ions, initiated its clinical activity in September 2011. The first treatment of a skull base tumor with protons is reported here. The case of a 26-year-old man with an intracranial low-grade chondrosarcoma of the right petroclival junction is discussed with emphasis on technical and clinical details. Two previous surgical interventions had achieved partial removal of the tumor and the patient was treated with protons for residual disease. The prescribed dose was 70 GyE in 35 fractions of 2 GyE. Treatment was completed with minimal acute toxicity consisting of grade 1 alopecia and nausea. Nine months after treatment the disease is locally controlled. Use of high-energy protons at CNAO is a safe and effective means of treating a tumor located near critical normal structures. |
| doi_str_mv | 10.1700/1283.14204 |
| format | Article |
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The Centro Nazionale di Adroterapia Oncologica (CNAO), equipped with a synchrotron and capable of using both protons and ions, initiated its clinical activity in September 2011. The first treatment of a skull base tumor with protons is reported here. The case of a 26-year-old man with an intracranial low-grade chondrosarcoma of the right petroclival junction is discussed with emphasis on technical and clinical details. Two previous surgical interventions had achieved partial removal of the tumor and the patient was treated with protons for residual disease. The prescribed dose was 70 GyE in 35 fractions of 2 GyE. Treatment was completed with minimal acute toxicity consisting of grade 1 alopecia and nausea. Nine months after treatment the disease is locally controlled. Use of high-energy protons at CNAO is a safe and effective means of treating a tumor located near critical normal structures.</description><identifier>EISSN: 2038-2529</identifier><identifier>DOI: 10.1700/1283.14204</identifier><identifier>PMID: 23748826</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Alopecia - etiology ; Chondrosarcoma - complications ; Chondrosarcoma - diagnosis ; Chondrosarcoma - radiotherapy ; Chondrosarcoma - surgery ; Diplopia - etiology ; Dose Fractionation ; Dose-Response Relationship, Radiation ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Nausea - etiology ; Neoplasm Grading ; Neoplasm Recurrence, Local - diagnosis ; Neoplasm Recurrence, Local - radiotherapy ; Protons - adverse effects ; Protons - therapeutic use ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Computer-Assisted - methods ; Skull Base Neoplasms - complications ; Skull Base Neoplasms - diagnosis ; Skull Base Neoplasms - radiotherapy ; Skull Base Neoplasms - surgery ; Synchrotrons ; Tomography, X-Ray Computed</subject><ispartof>Tumori, 2013-03, Vol.99 (2), p.e34</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23748826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orecchia, Roberto</creatorcontrib><creatorcontrib>Srivastava, Anurita</creatorcontrib><creatorcontrib>Fiore, Maria Rosaria</creatorcontrib><creatorcontrib>Vitolo, Viviana</creatorcontrib><creatorcontrib>Fossati, Piero</creatorcontrib><creatorcontrib>Vischioni, Barbara</creatorcontrib><creatorcontrib>Iannalfi, Alberto</creatorcontrib><creatorcontrib>Tuan, Jeffrey</creatorcontrib><creatorcontrib>Ciocca, Mario</creatorcontrib><creatorcontrib>Molinelli, Silvia</creatorcontrib><creatorcontrib>Mirandola, Alfredo</creatorcontrib><creatorcontrib>Vilches, Gloria</creatorcontrib><creatorcontrib>Mairani, Andrea</creatorcontrib><creatorcontrib>Tagaste, Barbara</creatorcontrib><creatorcontrib>Baroni, Guido</creatorcontrib><creatorcontrib>Rossi, Sandro</creatorcontrib><creatorcontrib>Krengli, Marco</creatorcontrib><title>Proton beam radiotherapy: report of the first patient treated at the Centro Nazionale di Adroterapia Oncologica (CNAO) [National Center of Oncologic Hadron Therapy]</title><title>Tumori</title><addtitle>Tumori</addtitle><description>Proton beam radiotherapy, an innovative treatment modality, allows delivery of high radiation doses to the target while sparing surrounding healthy structures. The Centro Nazionale di Adroterapia Oncologica (CNAO), equipped with a synchrotron and capable of using both protons and ions, initiated its clinical activity in September 2011. The first treatment of a skull base tumor with protons is reported here. The case of a 26-year-old man with an intracranial low-grade chondrosarcoma of the right petroclival junction is discussed with emphasis on technical and clinical details. Two previous surgical interventions had achieved partial removal of the tumor and the patient was treated with protons for residual disease. The prescribed dose was 70 GyE in 35 fractions of 2 GyE. Treatment was completed with minimal acute toxicity consisting of grade 1 alopecia and nausea. Nine months after treatment the disease is locally controlled. Use of high-energy protons at CNAO is a safe and effective means of treating a tumor located near critical normal structures.</description><subject>Adult</subject><subject>Alopecia - etiology</subject><subject>Chondrosarcoma - complications</subject><subject>Chondrosarcoma - diagnosis</subject><subject>Chondrosarcoma - radiotherapy</subject><subject>Chondrosarcoma - surgery</subject><subject>Diplopia - etiology</subject><subject>Dose Fractionation</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Nausea - etiology</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Neoplasm Recurrence, Local - radiotherapy</subject><subject>Protons - adverse effects</subject><subject>Protons - therapeutic use</subject><subject>Radiotherapy Planning, Computer-Assisted</subject><subject>Radiotherapy, Computer-Assisted - methods</subject><subject>Skull Base Neoplasms - complications</subject><subject>Skull Base Neoplasms - diagnosis</subject><subject>Skull Base Neoplasms - radiotherapy</subject><subject>Skull Base Neoplasms - surgery</subject><subject>Synchrotrons</subject><subject>Tomography, X-Ray Computed</subject><issn>2038-2529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFOwzAQRC0kREvhwgegPcIhxXZiO-FWVUCRUMuhN4SqTbwBozaOHHMo38OHkrbAaaXZmbejZexC8LEwnN8ImadjkUmeHbGh5GmeSCWLATvtug_OMy61PmEDmZosz6Uesu_n4KNvoCTcQEDrfHyngO32FgK1PkTwNfQS1C50EVqMjpoIMRBGsoBxv5z2WvAwxy_nG1wTWAcT25N3KIewaCq_9m-uQriazieLa3iZ96Sdd5-lsDvz74IZ9uEGlocqr2fsuMZ1R-e_c8SW93fL6Sx5Wjw8TidPSau0TjAXWV4it2SEytJCVcpQIbnRpdTCGspVZpUpMZVUGFGKoqqNxqJQnDiiSkfs8oBtP8sN2VUb3AbDdvX3rfQHFalqyw</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Orecchia, Roberto</creator><creator>Srivastava, Anurita</creator><creator>Fiore, Maria Rosaria</creator><creator>Vitolo, Viviana</creator><creator>Fossati, Piero</creator><creator>Vischioni, Barbara</creator><creator>Iannalfi, Alberto</creator><creator>Tuan, Jeffrey</creator><creator>Ciocca, Mario</creator><creator>Molinelli, Silvia</creator><creator>Mirandola, Alfredo</creator><creator>Vilches, Gloria</creator><creator>Mairani, Andrea</creator><creator>Tagaste, Barbara</creator><creator>Baroni, Guido</creator><creator>Rossi, Sandro</creator><creator>Krengli, Marco</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201303</creationdate><title>Proton beam radiotherapy: report of the first patient treated at the Centro Nazionale di Adroterapia Oncologica (CNAO) [National Center of Oncologic Hadron Therapy]</title><author>Orecchia, Roberto ; Srivastava, Anurita ; Fiore, Maria Rosaria ; Vitolo, Viviana ; Fossati, Piero ; Vischioni, Barbara ; Iannalfi, Alberto ; Tuan, Jeffrey ; Ciocca, Mario ; Molinelli, Silvia ; Mirandola, Alfredo ; Vilches, Gloria ; Mairani, Andrea ; Tagaste, Barbara ; Baroni, Guido ; Rossi, Sandro ; Krengli, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p566-a8148ba0de7154395c57e92076b261d7e854d57ba32e971b19cf76a9950e0aa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Alopecia - etiology</topic><topic>Chondrosarcoma - complications</topic><topic>Chondrosarcoma - diagnosis</topic><topic>Chondrosarcoma - radiotherapy</topic><topic>Chondrosarcoma - surgery</topic><topic>Diplopia - etiology</topic><topic>Dose Fractionation</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Nausea - etiology</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Neoplasm Recurrence, Local - radiotherapy</topic><topic>Protons - adverse effects</topic><topic>Protons - therapeutic use</topic><topic>Radiotherapy Planning, Computer-Assisted</topic><topic>Radiotherapy, Computer-Assisted - methods</topic><topic>Skull Base Neoplasms - complications</topic><topic>Skull Base Neoplasms - diagnosis</topic><topic>Skull Base Neoplasms - radiotherapy</topic><topic>Skull Base Neoplasms - surgery</topic><topic>Synchrotrons</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orecchia, Roberto</creatorcontrib><creatorcontrib>Srivastava, Anurita</creatorcontrib><creatorcontrib>Fiore, Maria Rosaria</creatorcontrib><creatorcontrib>Vitolo, Viviana</creatorcontrib><creatorcontrib>Fossati, Piero</creatorcontrib><creatorcontrib>Vischioni, Barbara</creatorcontrib><creatorcontrib>Iannalfi, Alberto</creatorcontrib><creatorcontrib>Tuan, Jeffrey</creatorcontrib><creatorcontrib>Ciocca, Mario</creatorcontrib><creatorcontrib>Molinelli, Silvia</creatorcontrib><creatorcontrib>Mirandola, Alfredo</creatorcontrib><creatorcontrib>Vilches, Gloria</creatorcontrib><creatorcontrib>Mairani, Andrea</creatorcontrib><creatorcontrib>Tagaste, Barbara</creatorcontrib><creatorcontrib>Baroni, Guido</creatorcontrib><creatorcontrib>Rossi, Sandro</creatorcontrib><creatorcontrib>Krengli, Marco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Tumori</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orecchia, Roberto</au><au>Srivastava, Anurita</au><au>Fiore, Maria Rosaria</au><au>Vitolo, Viviana</au><au>Fossati, Piero</au><au>Vischioni, Barbara</au><au>Iannalfi, Alberto</au><au>Tuan, Jeffrey</au><au>Ciocca, Mario</au><au>Molinelli, Silvia</au><au>Mirandola, Alfredo</au><au>Vilches, Gloria</au><au>Mairani, Andrea</au><au>Tagaste, Barbara</au><au>Baroni, Guido</au><au>Rossi, Sandro</au><au>Krengli, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proton beam radiotherapy: report of the first patient treated at the Centro Nazionale di Adroterapia Oncologica (CNAO) [National Center of Oncologic Hadron Therapy]</atitle><jtitle>Tumori</jtitle><addtitle>Tumori</addtitle><date>2013-03</date><risdate>2013</risdate><volume>99</volume><issue>2</issue><spage>e34</spage><pages>e34-</pages><eissn>2038-2529</eissn><abstract>Proton beam radiotherapy, an innovative treatment modality, allows delivery of high radiation doses to the target while sparing surrounding healthy structures. The Centro Nazionale di Adroterapia Oncologica (CNAO), equipped with a synchrotron and capable of using both protons and ions, initiated its clinical activity in September 2011. The first treatment of a skull base tumor with protons is reported here. The case of a 26-year-old man with an intracranial low-grade chondrosarcoma of the right petroclival junction is discussed with emphasis on technical and clinical details. Two previous surgical interventions had achieved partial removal of the tumor and the patient was treated with protons for residual disease. The prescribed dose was 70 GyE in 35 fractions of 2 GyE. Treatment was completed with minimal acute toxicity consisting of grade 1 alopecia and nausea. Nine months after treatment the disease is locally controlled. Use of high-energy protons at CNAO is a safe and effective means of treating a tumor located near critical normal structures.</abstract><cop>United States</cop><pmid>23748826</pmid><doi>10.1700/1283.14204</doi></addata></record> |
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| subjects | Adult Alopecia - etiology Chondrosarcoma - complications Chondrosarcoma - diagnosis Chondrosarcoma - radiotherapy Chondrosarcoma - surgery Diplopia - etiology Dose Fractionation Dose-Response Relationship, Radiation Humans Magnetic Resonance Imaging - methods Male Nausea - etiology Neoplasm Grading Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - radiotherapy Protons - adverse effects Protons - therapeutic use Radiotherapy Planning, Computer-Assisted Radiotherapy, Computer-Assisted - methods Skull Base Neoplasms - complications Skull Base Neoplasms - diagnosis Skull Base Neoplasms - radiotherapy Skull Base Neoplasms - surgery Synchrotrons Tomography, X-Ray Computed |
| title | Proton beam radiotherapy: report of the first patient treated at the Centro Nazionale di Adroterapia Oncologica (CNAO) [National Center of Oncologic Hadron Therapy] |
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