Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells

The thymus provides multiple microenvironments that are essential for the development and repertoire selection of T lymphocytes. The thymic cortex induces the generation and positive selection of T lymphocytes, whereas the thymic medulla establishes self-tolerance among the positively selected T lym...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-06, Vol.110 (24), p.9885-9890
Hauptverfasser:	Ohigashi, Izumi, Zuklys, Saulius, Sakata, Mie, Mayer, Carlos E., Zhanybekova, Saule, Murata, Shigeo, Tanaka, Keiji, Holländer, Georg A., Takahama, Yousuke
Format:	Artikel
Sprache:	eng
Schlagworte:	AIRE Protein Animals Biological Sciences Cells cortex crossing Developmental biology Epithelial cells Epithelial Cells - metabolism epithelium Flow Cytometry Fluorescence Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Integrases - genetics Integrases - metabolism Male Messenger RNA Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microscopy, Confocal Progenitor cells proteasome endopeptidase complex Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Stem cells Stem Cells - metabolism stromal cells T lymphocytes T-Lymphocytes - metabolism Thymocytes thymus gland Thymus Gland - cytology Thymus Gland - embryology Thymus Gland - metabolism Time Factors Transcription Factors - metabolism
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