Changing Spectrum of Biopsy-Proven Primary Glomerular Diseases over the Past 15 Years: A Single-Center Study in China
The prevalence of chronic kidney disease (CKD) is reported to be 10.8-11.8% of the Chinese population. With economic development and longer life expectancy, the spectrum of CKD etiology has kept changing. Primary glomerular diseases (PGD) are still the most common renal diseases in China. To investi...
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| Veröffentlicht in: | Contributions to nephrology 2013-01, Vol.181, p.22-30 |
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| creator | Pan, Xiaoxia Xu, Jing Ren, Hong Zhang, Wen Xu, Yaowen Shen, Pingyan Li, Xiao Wang, Weiming Chen, Xiaonong Wu, Pei Feng, Xiaobei Hao, Cuilan Chen, Nan |
| description | The prevalence of chronic kidney disease (CKD) is reported to be 10.8-11.8% of the Chinese population. With economic development and longer life expectancy, the spectrum of CKD etiology has kept changing. Primary glomerular diseases (PGD) are still the most common renal diseases in China. To investigate the changing pattern of PGD in China, we retrospectively analyzed consecutive native renal biopsies performed in our hospital from 1997 to 2011. The patients were grouped according to a 3-year interval, 1997-1999 (period 1), 2000-2002 (period 2), 2003-2005 (period 3), 2006-2008 (period 4), 2009-2011 (period 5), and divided into three age groups ( |
| doi_str_mv | 10.1159/000348638 |
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With economic development and longer life expectancy, the spectrum of CKD etiology has kept changing. Primary glomerular diseases (PGD) are still the most common renal diseases in China. To investigate the changing pattern of PGD in China, we retrospectively analyzed consecutive native renal biopsies performed in our hospital from 1997 to 2011. The patients were grouped according to a 3-year interval, 1997-1999 (period 1), 2000-2002 (period 2), 2003-2005 (period 3), 2006-2008 (period 4), 2009-2011 (period 5), and divided into three age groups (<20, 20-59, and ≥60 years old). 8,909 qualified cases were enrolled in this study. Among 8,909 specimens, 6,337 (71.13%) were diagnosed as PGD, while this prevalence decreased significantly from 77.61% in 1997-1999 to 66.73% in 2006-2008. IgA nephropathy (IgAN) was the most common PGD (36.66%), without any significant difference in the 5 periods (p = 0.185). IgAN was the most common PGD both in patients between the 20- to 59-year-old group (45.58%) and <20-year-old group (19.29%) as well. Membranous nephropathy (MN) was the most frequently found PGD in patients at age ≥60 years (39.64%). The frequency of MN was increased significantly from 6.48% in 1997-1999 to 22.79% in 2009-2011 (p < 0.001). The proportion of elderly patients increased significantly from 3.18% in 1997-1999 to 15.21% in 2009-2011 (p < 0.001). The prevalence of endocapillary proliferative glomerulonephritis (EnPGN) has decreased since 1997. PGD has remained the most common renal disease in China, although with a descending trend. The spectrum of PGD is different in different age groups. The frequency of EnPGN has decreased significantly, while that of MN has increased significantly.</description><identifier>ISSN: 0302-5144</identifier><identifier>ISBN: 3318023892</identifier><identifier>ISBN: 9783318023893</identifier><identifier>EISSN: 1662-2782</identifier><identifier>EISBN: 3318023906</identifier><identifier>EISBN: 9783318023909</identifier><identifier>DOI: 10.1159/000348638</identifier><identifier>PMID: 23689564</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Biopsy ; Chapter ; China - epidemiology ; Female ; Glomerulonephritis - epidemiology ; Humans ; Kidney Glomerulus - pathology ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Time Factors</subject><ispartof>Contributions to nephrology, 2013-01, Vol.181, p.22-30</ispartof><rights>2013 S. Karger AG, Basel</rights><rights>Copyright © 2013 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-6fca0331e211c80dff06fd8a91e23b369791de56d7e997f24bb19c66f5c5e14c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,779,780,784,793,24779,26079,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23689564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chen N</contributor><creatorcontrib>Pan, Xiaoxia</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Ren, Hong</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><creatorcontrib>Xu, Yaowen</creatorcontrib><creatorcontrib>Shen, Pingyan</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Wang, Weiming</creatorcontrib><creatorcontrib>Chen, Xiaonong</creatorcontrib><creatorcontrib>Wu, Pei</creatorcontrib><creatorcontrib>Feng, Xiaobei</creatorcontrib><creatorcontrib>Hao, Cuilan</creatorcontrib><creatorcontrib>Chen, Nan</creatorcontrib><title>Changing Spectrum of Biopsy-Proven Primary Glomerular Diseases over the Past 15 Years: A Single-Center Study in China</title><title>Contributions to nephrology</title><addtitle>Contrib Nephrol</addtitle><description>The prevalence of chronic kidney disease (CKD) is reported to be 10.8-11.8% of the Chinese population. With economic development and longer life expectancy, the spectrum of CKD etiology has kept changing. Primary glomerular diseases (PGD) are still the most common renal diseases in China. To investigate the changing pattern of PGD in China, we retrospectively analyzed consecutive native renal biopsies performed in our hospital from 1997 to 2011. The patients were grouped according to a 3-year interval, 1997-1999 (period 1), 2000-2002 (period 2), 2003-2005 (period 3), 2006-2008 (period 4), 2009-2011 (period 5), and divided into three age groups (<20, 20-59, and ≥60 years old). 8,909 qualified cases were enrolled in this study. Among 8,909 specimens, 6,337 (71.13%) were diagnosed as PGD, while this prevalence decreased significantly from 77.61% in 1997-1999 to 66.73% in 2006-2008. IgA nephropathy (IgAN) was the most common PGD (36.66%), without any significant difference in the 5 periods (p = 0.185). IgAN was the most common PGD both in patients between the 20- to 59-year-old group (45.58%) and <20-year-old group (19.29%) as well. Membranous nephropathy (MN) was the most frequently found PGD in patients at age ≥60 years (39.64%). The frequency of MN was increased significantly from 6.48% in 1997-1999 to 22.79% in 2009-2011 (p < 0.001). The proportion of elderly patients increased significantly from 3.18% in 1997-1999 to 15.21% in 2009-2011 (p < 0.001). The prevalence of endocapillary proliferative glomerulonephritis (EnPGN) has decreased since 1997. PGD has remained the most common renal disease in China, although with a descending trend. The spectrum of PGD is different in different age groups. The frequency of EnPGN has decreased significantly, while that of MN has increased significantly.</description><subject>Adult</subject><subject>Aged</subject><subject>Biopsy</subject><subject>Chapter</subject><subject>China - epidemiology</subject><subject>Female</subject><subject>Glomerulonephritis - epidemiology</subject><subject>Humans</subject><subject>Kidney Glomerulus - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Time Factors</subject><issn>0302-5144</issn><issn>1662-2782</issn><isbn>3318023892</isbn><isbn>9783318023893</isbn><isbn>3318023906</isbn><isbn>9783318023909</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90clOwzAQBmCziS5w4AWQuXEJeIldm1sJUJAqUalw4BQ5yaQ1ZMNOkPr2RErhNNLMp1-aGYQuKLmhVOhbQggPleTqAE04p4owrok8RGMqJQvYTLGj_4HS7BiNCScsEDQMR2ji_SchQiutT9GIcam0kOEYddHWVBtbbfC6gbR1XYnrHN_buvG7YOXqH6jwytnSuB1eFHUJriuMww_Wg_HgcQ8cbreAV8a3mAr8Acb5OzzH6z60gCCCqu3Juu2yHbYVjra2MmfoJDeFh_N9naL3p8e36DlYvi5eovkySEPK20DmqSH9RsAoTRXJ8pzIPFNG9x2ecKlnmmYgZDYDrWc5C5OE6lTKXKQCaJjyKboechtXf3fg27i0PoWiMBXUnY8pF1wrIZXo6eWedkkJWdwMS8d_p-rB1QC-jNuAiyGp6y_vwVnw8fAY_gvdk3kn</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Pan, Xiaoxia</creator><creator>Xu, Jing</creator><creator>Ren, Hong</creator><creator>Zhang, Wen</creator><creator>Xu, Yaowen</creator><creator>Shen, Pingyan</creator><creator>Li, Xiao</creator><creator>Wang, Weiming</creator><creator>Chen, Xiaonong</creator><creator>Wu, Pei</creator><creator>Feng, Xiaobei</creator><creator>Hao, Cuilan</creator><creator>Chen, Nan</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Changing Spectrum of Biopsy-Proven Primary Glomerular Diseases over the Past 15 Years: A Single-Center Study in China</title><author>Pan, Xiaoxia ; Xu, Jing ; Ren, Hong ; Zhang, Wen ; Xu, Yaowen ; Shen, Pingyan ; Li, Xiao ; Wang, Weiming ; Chen, Xiaonong ; Wu, Pei ; Feng, Xiaobei ; Hao, Cuilan ; Chen, Nan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-6fca0331e211c80dff06fd8a91e23b369791de56d7e997f24bb19c66f5c5e14c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biopsy</topic><topic>Chapter</topic><topic>China - epidemiology</topic><topic>Female</topic><topic>Glomerulonephritis - epidemiology</topic><topic>Humans</topic><topic>Kidney Glomerulus - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pan, Xiaoxia</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Ren, Hong</creatorcontrib><creatorcontrib>Zhang, Wen</creatorcontrib><creatorcontrib>Xu, Yaowen</creatorcontrib><creatorcontrib>Shen, Pingyan</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Wang, Weiming</creatorcontrib><creatorcontrib>Chen, Xiaonong</creatorcontrib><creatorcontrib>Wu, Pei</creatorcontrib><creatorcontrib>Feng, Xiaobei</creatorcontrib><creatorcontrib>Hao, Cuilan</creatorcontrib><creatorcontrib>Chen, Nan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Contributions to nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pan, Xiaoxia</au><au>Xu, Jing</au><au>Ren, Hong</au><au>Zhang, Wen</au><au>Xu, Yaowen</au><au>Shen, Pingyan</au><au>Li, Xiao</au><au>Wang, Weiming</au><au>Chen, Xiaonong</au><au>Wu, Pei</au><au>Feng, Xiaobei</au><au>Hao, Cuilan</au><au>Chen, Nan</au><au>Chen N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing Spectrum of Biopsy-Proven Primary Glomerular Diseases over the Past 15 Years: A Single-Center Study in China</atitle><jtitle>Contributions to nephrology</jtitle><addtitle>Contrib Nephrol</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>181</volume><spage>22</spage><epage>30</epage><pages>22-30</pages><issn>0302-5144</issn><eissn>1662-2782</eissn><isbn>3318023892</isbn><isbn>9783318023893</isbn><eisbn>3318023906</eisbn><eisbn>9783318023909</eisbn><abstract>The prevalence of chronic kidney disease (CKD) is reported to be 10.8-11.8% of the Chinese population. With economic development and longer life expectancy, the spectrum of CKD etiology has kept changing. Primary glomerular diseases (PGD) are still the most common renal diseases in China. To investigate the changing pattern of PGD in China, we retrospectively analyzed consecutive native renal biopsies performed in our hospital from 1997 to 2011. The patients were grouped according to a 3-year interval, 1997-1999 (period 1), 2000-2002 (period 2), 2003-2005 (period 3), 2006-2008 (period 4), 2009-2011 (period 5), and divided into three age groups (<20, 20-59, and ≥60 years old). 8,909 qualified cases were enrolled in this study. Among 8,909 specimens, 6,337 (71.13%) were diagnosed as PGD, while this prevalence decreased significantly from 77.61% in 1997-1999 to 66.73% in 2006-2008. IgA nephropathy (IgAN) was the most common PGD (36.66%), without any significant difference in the 5 periods (p = 0.185). IgAN was the most common PGD both in patients between the 20- to 59-year-old group (45.58%) and <20-year-old group (19.29%) as well. Membranous nephropathy (MN) was the most frequently found PGD in patients at age ≥60 years (39.64%). The frequency of MN was increased significantly from 6.48% in 1997-1999 to 22.79% in 2009-2011 (p < 0.001). The proportion of elderly patients increased significantly from 3.18% in 1997-1999 to 15.21% in 2009-2011 (p < 0.001). The prevalence of endocapillary proliferative glomerulonephritis (EnPGN) has decreased since 1997. PGD has remained the most common renal disease in China, although with a descending trend. The spectrum of PGD is different in different age groups. The frequency of EnPGN has decreased significantly, while that of MN has increased significantly.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>23689564</pmid><doi>10.1159/000348638</doi><tpages>9</tpages></addata></record> |
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| ispartof | Contributions to nephrology, 2013-01, Vol.181, p.22-30 |
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| language | eng |
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| source | MEDLINE; Karger Book Series |
| subjects | Adult Aged Biopsy Chapter China - epidemiology Female Glomerulonephritis - epidemiology Humans Kidney Glomerulus - pathology Male Middle Aged Prevalence Retrospective Studies Time Factors |
| title | Changing Spectrum of Biopsy-Proven Primary Glomerular Diseases over the Past 15 Years: A Single-Center Study in China |
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