Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Autophagy is a highly conserved degradative pathway that has rapidly emerged as a critical component of immunity and host defense. Studies have implicated autophagy genes in restricting the replication of a diverse array of pathogens, including bacteria, viruses and protozoans. However, in most case...
Gespeichert in:
| Veröffentlicht in: | Journal of innate immunity 2013-01, Vol.5 (5), p.444-455 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 455 |
|---|---|
| container_issue | 5 |
| container_start_page | 444 |
| container_title | Journal of innate immunity |
| container_volume | 5 |
| creator | Moy, Ryan H. Cherry, Sara |
| description | Autophagy is a highly conserved degradative pathway that has rapidly emerged as a critical component of immunity and host defense. Studies have implicated autophagy genes in restricting the replication of a diverse array of pathogens, including bacteria, viruses and protozoans. However, in most cases, the in vivo role of antimicrobial autophagy against pathogens has been undefined. Drosophila provides a genetically tractable model system that can be easily adapted to study autophagy in innate immunity, and recent studies in flies have demonstrated that autophagy is an essential antimicrobial response against bacteria and viruses in vivo. These findings reveal striking conservation of antimicrobial autophagy between flies and mammals, and in particular, the role of pathogen-associated pattern recognition in triggering this response. This review discusses our current understanding of antimicrobial autophagy in Drosophila and its potential relevance to human immunity. |
| doi_str_mv | 10.1159/000350326 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_23689401</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1412507608</sourcerecordid><originalsourceid>FETCH-LOGICAL-c551t-1dee6e894324280e53cdbc1971a6c07485395481c6842692d7b69932d178a43e3</originalsourceid><addsrcrecordid>eNqNkc9rFDEUx4MotlYP3kUGvOhha35NfvRQWFZrp5QWRMFbyM683abOJNNkptD_vll2O1rx0FwSeJ98v--9L0JvCT4kpNSfMcasxIyKZ2ifCEFnilD1fHqTX3voVUrXGAvOtXyJ9igTSnNM9lE194PrXB3D0tm2mI9D6K_s-u6omBeL4BPEW2iKyns7QFF13eih-A6p35QK54svMaT8w7X2NXqxsm2CN7v7AP08-fpjcTo7v_xWLebns7osyTAjDYCA7M4opwpDyepmWRMtiRU1llyVTJdckVooToWmjVwKrRltiFSWM2AH6Hir24_LDpoa_BBta_roOhvvTLDOPK54d2XW4dYwqfNRWeDjTiCGmxHSYDqXamhb6yGMyRDOOKaaafIElNASS4E3qh_-Qa_DGH3exIbSUnEsdaY-bam88JQirKa-CTabLM2UZWbf_z3oRD6E98fyt41riBNwVl1sJUzfrDL17r_UzuUeW6asGA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1419784079</pqid></control><display><type>article</type><title>Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Moy, Ryan H. ; Cherry, Sara</creator><creatorcontrib>Moy, Ryan H. ; Cherry, Sara</creatorcontrib><description>Autophagy is a highly conserved degradative pathway that has rapidly emerged as a critical component of immunity and host defense. Studies have implicated autophagy genes in restricting the replication of a diverse array of pathogens, including bacteria, viruses and protozoans. However, in most cases, the in vivo role of antimicrobial autophagy against pathogens has been undefined. Drosophila provides a genetically tractable model system that can be easily adapted to study autophagy in innate immunity, and recent studies in flies have demonstrated that autophagy is an essential antimicrobial response against bacteria and viruses in vivo. These findings reveal striking conservation of antimicrobial autophagy between flies and mammals, and in particular, the role of pathogen-associated pattern recognition in triggering this response. This review discusses our current understanding of antimicrobial autophagy in Drosophila and its potential relevance to human immunity.</description><identifier>ISSN: 1662-811X</identifier><identifier>EISSN: 1662-8128</identifier><identifier>DOI: 10.1159/000350326</identifier><identifier>PMID: 23689401</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Antimicrobial agents ; Autophagy ; Biological Evolution ; Conserved Sequence - genetics ; Drosophila ; Drosophila melanogaster - immunology ; Host-Pathogen Interactions - immunology ; Humans ; Immunity, Innate ; Infection - immunology ; Infection - microbiology ; Infection - virology ; Models, Animal ; Receptors, Pattern Recognition - metabolism ; Review</subject><ispartof>Journal of innate immunity, 2013-01, Vol.5 (5), p.444-455</ispartof><rights>2013 S. Karger AG, Basel</rights><rights>Copyright © 2013 S. Karger AG, Basel.</rights><rights>Copyright (c) 2013 S. Karger AG, Basel</rights><rights>Copyright © 2013 by S. Karger AG, Basel 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-1dee6e894324280e53cdbc1971a6c07485395481c6842692d7b69932d178a43e3</citedby><cites>FETCH-LOGICAL-c551t-1dee6e894324280e53cdbc1971a6c07485395481c6842692d7b69932d178a43e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799998/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799998/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23689401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moy, Ryan H.</creatorcontrib><creatorcontrib>Cherry, Sara</creatorcontrib><title>Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila</title><title>Journal of innate immunity</title><addtitle>J Innate Immun</addtitle><description>Autophagy is a highly conserved degradative pathway that has rapidly emerged as a critical component of immunity and host defense. Studies have implicated autophagy genes in restricting the replication of a diverse array of pathogens, including bacteria, viruses and protozoans. However, in most cases, the in vivo role of antimicrobial autophagy against pathogens has been undefined. Drosophila provides a genetically tractable model system that can be easily adapted to study autophagy in innate immunity, and recent studies in flies have demonstrated that autophagy is an essential antimicrobial response against bacteria and viruses in vivo. These findings reveal striking conservation of antimicrobial autophagy between flies and mammals, and in particular, the role of pathogen-associated pattern recognition in triggering this response. This review discusses our current understanding of antimicrobial autophagy in Drosophila and its potential relevance to human immunity.</description><subject>Animals</subject><subject>Antimicrobial agents</subject><subject>Autophagy</subject><subject>Biological Evolution</subject><subject>Conserved Sequence - genetics</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - immunology</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Infection - immunology</subject><subject>Infection - microbiology</subject><subject>Infection - virology</subject><subject>Models, Animal</subject><subject>Receptors, Pattern Recognition - metabolism</subject><subject>Review</subject><issn>1662-811X</issn><issn>1662-8128</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc9rFDEUx4MotlYP3kUGvOhha35NfvRQWFZrp5QWRMFbyM683abOJNNkptD_vll2O1rx0FwSeJ98v--9L0JvCT4kpNSfMcasxIyKZ2ifCEFnilD1fHqTX3voVUrXGAvOtXyJ9igTSnNM9lE194PrXB3D0tm2mI9D6K_s-u6omBeL4BPEW2iKyns7QFF13eih-A6p35QK54svMaT8w7X2NXqxsm2CN7v7AP08-fpjcTo7v_xWLebns7osyTAjDYCA7M4opwpDyepmWRMtiRU1llyVTJdckVooToWmjVwKrRltiFSWM2AH6Hir24_LDpoa_BBta_roOhvvTLDOPK54d2XW4dYwqfNRWeDjTiCGmxHSYDqXamhb6yGMyRDOOKaaafIElNASS4E3qh_-Qa_DGH3exIbSUnEsdaY-bam88JQirKa-CTabLM2UZWbf_z3oRD6E98fyt41riBNwVl1sJUzfrDL17r_UzuUeW6asGA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Moy, Ryan H.</creator><creator>Cherry, Sara</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila</title><author>Moy, Ryan H. ; Cherry, Sara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-1dee6e894324280e53cdbc1971a6c07485395481c6842692d7b69932d178a43e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Antimicrobial agents</topic><topic>Autophagy</topic><topic>Biological Evolution</topic><topic>Conserved Sequence - genetics</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - immunology</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Infection - immunology</topic><topic>Infection - microbiology</topic><topic>Infection - virology</topic><topic>Models, Animal</topic><topic>Receptors, Pattern Recognition - metabolism</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moy, Ryan H.</creatorcontrib><creatorcontrib>Cherry, Sara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of innate immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moy, Ryan H.</au><au>Cherry, Sara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila</atitle><jtitle>Journal of innate immunity</jtitle><addtitle>J Innate Immun</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>5</volume><issue>5</issue><spage>444</spage><epage>455</epage><pages>444-455</pages><issn>1662-811X</issn><eissn>1662-8128</eissn><abstract>Autophagy is a highly conserved degradative pathway that has rapidly emerged as a critical component of immunity and host defense. Studies have implicated autophagy genes in restricting the replication of a diverse array of pathogens, including bacteria, viruses and protozoans. However, in most cases, the in vivo role of antimicrobial autophagy against pathogens has been undefined. Drosophila provides a genetically tractable model system that can be easily adapted to study autophagy in innate immunity, and recent studies in flies have demonstrated that autophagy is an essential antimicrobial response against bacteria and viruses in vivo. These findings reveal striking conservation of antimicrobial autophagy between flies and mammals, and in particular, the role of pathogen-associated pattern recognition in triggering this response. This review discusses our current understanding of antimicrobial autophagy in Drosophila and its potential relevance to human immunity.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>23689401</pmid><doi>10.1159/000350326</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1662-811X |
| ispartof | Journal of innate immunity, 2013-01, Vol.5 (5), p.444-455 |
| issn | 1662-811X 1662-8128 |
| language | eng |
| recordid | cdi_pubmed_primary_23689401 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Antimicrobial agents Autophagy Biological Evolution Conserved Sequence - genetics Drosophila Drosophila melanogaster - immunology Host-Pathogen Interactions - immunology Humans Immunity, Innate Infection - immunology Infection - microbiology Infection - virology Models, Animal Receptors, Pattern Recognition - metabolism Review |
| title | Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T03%3A47%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antimicrobial%20Autophagy:%20A%20Conserved%20Innate%20Immune%20Response%20in%20Drosophila&rft.jtitle=Journal%20of%20innate%20immunity&rft.au=Moy,%20Ryan%20H.&rft.date=2013-01-01&rft.volume=5&rft.issue=5&rft.spage=444&rft.epage=455&rft.pages=444-455&rft.issn=1662-811X&rft.eissn=1662-8128&rft_id=info:doi/10.1159/000350326&rft_dat=%3Cproquest_pubme%3E1412507608%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1419784079&rft_id=info:pmid/23689401&rfr_iscdi=true |