Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

Analysis of correlates of risk of infection in the RV144 HIV-1 vaccine efficacy trial demonstrated that plasma IgG against the HIV-1 envelope (Env) variable region 1 and 2 inversely correlated with risk, whereas HIV-1 Env-specific plasma IgA responses directly correlated with risk. In the secondary...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-05, Vol.110 (22), p.9019-9024
Hauptverfasser:	Tomaras, Georgia D., Ferrari, Guido, Shen, Xiaoying, Alam, S. Munir, Liao, Hua-Xin, Pollara, Justin, Bonsignori, Mattia, Moody, M. Anthony, Fong, Youyi, Chen, Xi, Poling, Brigid, Nicholson, Cindo O., Zhang, Ruijun, Lu, Xiaozhi, Parks, Robert, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Rerks-Ngarm, Supachai, Gilbert, Peter B., Kim, Jerome H., Michael, Nelson L., Montefiori, David C., Haynes, Barton F.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - immunology Antibodies Antibodies, Monoclonal Antibody dependent cell cytotoxicity B lymphocytes binding sites Binding, Competitive - genetics Biological Sciences Correlation analysis cytotoxicity Enzyme-Linked Immunosorbent Assay Epitopes Glycoproteins HIV 1 HIV Envelope Protein gp120 - immunology HIV infections Human immunodeficiency virus 1 Humans immunity immunoglobulin A Immunoglobulin A - blood Immunoglobulin A - immunology immunoglobulin G Immunoglobulin G - metabolism Immunoglobulins Infections Isotypes Kinetics Logistic Models Memory Monoclonal antibodies natural killer cells Plasma polyclonal antibodies protective effect risk Risk Assessment Surface Plasmon Resonance T cell receptors T-lymphocytes Vaccination Vaccines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!