Klotho and Chronic Kidney Disease

Through alternative splicing, Klotho protein exists both as a secreted and a membrane form whose extracellular domain could be shed from the cell surface by secretases and released into the circulation to act as endocrine factor. Unlike membrane Klotho which functions as a coreceptor for fibroblast...

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Hauptverfasser: Hu, Ming Chang, Kuro-o, Makoto, Moe, Orson W.
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Kuro-o, Makoto
Moe, Orson W.
description Through alternative splicing, Klotho protein exists both as a secreted and a membrane form whose extracellular domain could be shed from the cell surface by secretases and released into the circulation to act as endocrine factor. Unlike membrane Klotho which functions as a coreceptor for fibroblast growth factor-23 (FGF23) to modulate FGF23 signal transduction, soluble Klotho is a multifunction protein present in the biological fluids including blood, urine and cerebrospinal fluid and plays important roles in antiaging, energy metabolism, inhibition of Wnt signaling, antioxidation, modulation of ion transport, control of parathyroid hormone and 1,25(OH) 2 VD 3 production, and antagonism of renin-angiotensin-aldosterone system. Emerging evidence from clinical and basic studies reveal that chronic kidney disease is a state of endocrine and renal Klotho deficiency, which may serve as an early biomarker and a pathogenic contributor to chronic progression and complications in chronic kidney disease including vascular calcification, cardiac hypertrophy, and secondary hyperparathyroidism. Supplementation of exogenous Klotho and/or upregulation of endogenous Klotho production by using rennin angiotensin system inhibitors, HMG CoA reductase inhibitors, vitamin D analogues, peroxisome proliferator-activated receptors-gamma agonists, or anti-oxidants may confer renoprotection from oxidation and suppression of renal fibrosis, and also on prevention or alleviation of complications in chronic kidney disease. Therefore, Klotho is a highly promising candidate on the horizon as an early biomarker, and as a novel therapeutic agent for chronic kidney disease.
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S</au><format>book</format><genre>bookitem</genre><ristype>CHAP</ristype><atitle>Klotho and Chronic Kidney Disease</atitle><btitle>Contributions to nephrology</btitle><addtitle>Contrib Nephrol</addtitle><seriestitle>Phosphate and Vitamin D in Chronic Kidney Disease</seriestitle><date>2013-01-01</date><risdate>2013</risdate><volume>180</volume><spage>47</spage><epage>63</epage><pages>47-63</pages><issn>0302-5144</issn><eissn>1662-2782</eissn><isbn>3318023698</isbn><isbn>9783318023695</isbn><eisbn>9783318023701</eisbn><eisbn>3318023701</eisbn><abstract>Through alternative splicing, Klotho protein exists both as a secreted and a membrane form whose extracellular domain could be shed from the cell surface by secretases and released into the circulation to act as endocrine factor. 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Supplementation of exogenous Klotho and/or upregulation of endogenous Klotho production by using rennin angiotensin system inhibitors, HMG CoA reductase inhibitors, vitamin D analogues, peroxisome proliferator-activated receptors-gamma agonists, or anti-oxidants may confer renoprotection from oxidation and suppression of renal fibrosis, and also on prevention or alleviation of complications in chronic kidney disease. Therefore, Klotho is a highly promising candidate on the horizon as an early biomarker, and as a novel therapeutic agent for chronic kidney disease.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>23652549</pmid><doi>10.1159/000346778</doi><oclcid>853069395</oclcid><tpages>17</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0302-5144
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language eng
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source MEDLINE; Karger Book Series
subjects Aging - metabolism
Animals
Calcinosis - metabolism
Calcium - metabolism
Cardiomyopathies - etiology
Cardiomyopathies - metabolism
Chapter
Chronic Kidney Disease-Mineral and Bone Disorder - metabolism
Disease Models, Animal
Disease Progression
Endocrinology
Fibroblast Growth Factor-23
Fibroblast Growth Factors - physiology
Glucuronidase - deficiency
Glucuronidase - physiology
Humans
Hyperparathyroidism, Secondary - metabolism
Klotho Proteins
Membrane Proteins - physiology
Nephrosclerosis - etiology
Parathyroid Hormone - metabolism
Phosphates - metabolism
Physiology
Renal Insufficiency, Chronic - metabolism
Renal medicine
Renin-Angiotensin System - physiology
Signal Transduction
Solubility
Uremia - complications
Uremia - metabolism
Vitamin D - metabolism
title Klotho and Chronic Kidney Disease
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