Plasma Kynurenic Acid/Tryptophan Ratio: A Sensitive and Reliable Biomarker for the Assessment of Renal Function
Background: Decreased tryptophan (TRP) and increased kynurenine (KYN) and kynurenic acid (KYNA) in blood have been reported in patients and experimental animals with renal diseases. We investigated if these compounds could be used as new biomarkers for the assessment of renal function. Methods: Eigh...
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| Veröffentlicht in: | Renal failure 2013-01, Vol.35 (5), p.648-653 |
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| description | Background: Decreased tryptophan (TRP) and increased kynurenine (KYN) and kynurenic acid (KYNA) in blood have been reported in patients and experimental animals with renal diseases. We investigated if these compounds could be used as new biomarkers for the assessment of renal function. Methods: Eighty hospitalized hypertensive patients (20 with chronic kidney disease (CKD), and other 60 were considered as control) were enrolled for the investigation. Plasma TRP, KYN, and KYNA were determined by high-performance liquid chromatography. Change rate (CR) was employed to evaluate the sensitivity of the parameters of renal function. Results: CR of plasma KYNA/TRP ratio (+103%) was much higher than the CRs of blood urea nitrogen (+44%), serum creatinine (+56%) and estimated glomerular filtration rate (-35%). Plasma KYNA/TRP ratio was in close relationship with blood urea nitrogen (r = 0.622), serum creatinine (r = 0.797), urine micro-albumin/24-h (r = 0.518) and estimated glomerular filtration rate (r = -0.662), respectively, with all p-values |
| doi_str_mv | 10.3109/0886022X.2013.790301 |
| format | Article |
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We investigated if these compounds could be used as new biomarkers for the assessment of renal function. Methods: Eighty hospitalized hypertensive patients (20 with chronic kidney disease (CKD), and other 60 were considered as control) were enrolled for the investigation. Plasma TRP, KYN, and KYNA were determined by high-performance liquid chromatography. Change rate (CR) was employed to evaluate the sensitivity of the parameters of renal function. Results: CR of plasma KYNA/TRP ratio (+103%) was much higher than the CRs of blood urea nitrogen (+44%), serum creatinine (+56%) and estimated glomerular filtration rate (-35%). Plasma KYNA/TRP ratio was in close relationship with blood urea nitrogen (r = 0.622), serum creatinine (r = 0.797), urine micro-albumin/24-h (r = 0.518) and estimated glomerular filtration rate (r = -0.662), respectively, with all p-values <0.001. Conclusions: Plasma KYNA/TRP ratio was sensitive and reliable to indicate renal function and could be used as a new biomarker to assess the risk or presence of kidney disease.</description><identifier>ISSN: 0886-022X</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.3109/0886022X.2013.790301</identifier><identifier>PMID: 23650931</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Aged ; Chromatography, High Pressure Liquid ; chronic kidney disease ; Female ; Humans ; Hypertension - blood ; Hypertension - complications ; Kidney Function Tests ; kynurenic acid ; Kynurenic Acid - blood ; kynurenine ; Kynurenine - blood ; Male ; Middle Aged ; plasma ; renal function ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - complications ; tryptophan ; Tryptophan - blood</subject><ispartof>Renal failure, 2013-01, Vol.35 (5), p.648-653</ispartof><rights>2013 Informa Healthcare USA, Inc. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-acf46b3b8987489249dca29ab6a4de9ede386c18bff327b66399cfbb6cedafd53</citedby><cites>FETCH-LOGICAL-c581t-acf46b3b8987489249dca29ab6a4de9ede386c18bff327b66399cfbb6cedafd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23650931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Jianxing</creatorcontrib><title>Plasma Kynurenic Acid/Tryptophan Ratio: A Sensitive and Reliable Biomarker for the Assessment of Renal Function</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description>Background: Decreased tryptophan (TRP) and increased kynurenine (KYN) and kynurenic acid (KYNA) in blood have been reported in patients and experimental animals with renal diseases. We investigated if these compounds could be used as new biomarkers for the assessment of renal function. Methods: Eighty hospitalized hypertensive patients (20 with chronic kidney disease (CKD), and other 60 were considered as control) were enrolled for the investigation. Plasma TRP, KYN, and KYNA were determined by high-performance liquid chromatography. Change rate (CR) was employed to evaluate the sensitivity of the parameters of renal function. Results: CR of plasma KYNA/TRP ratio (+103%) was much higher than the CRs of blood urea nitrogen (+44%), serum creatinine (+56%) and estimated glomerular filtration rate (-35%). Plasma KYNA/TRP ratio was in close relationship with blood urea nitrogen (r = 0.622), serum creatinine (r = 0.797), urine micro-albumin/24-h (r = 0.518) and estimated glomerular filtration rate (r = -0.662), respectively, with all p-values <0.001. Conclusions: Plasma KYNA/TRP ratio was sensitive and reliable to indicate renal function and could be used as a new biomarker to assess the risk or presence of kidney disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Chromatography, High Pressure Liquid</subject><subject>chronic kidney disease</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - complications</subject><subject>Kidney Function Tests</subject><subject>kynurenic acid</subject><subject>Kynurenic Acid - blood</subject><subject>kynurenine</subject><subject>Kynurenine - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>plasma</subject><subject>renal function</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>tryptophan</subject><subject>Tryptophan - blood</subject><issn>0886-022X</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EokvhHyDkI5ds_ZF4bQ6gpaKAqAQqReJmTZyx1iWxt3YC2n9Pom2RuPQ0l2fed-Yh5CVna8mZOWNaKybEz7VgXK43hknGH5EVb0RTKVabx2S1INXCnJBnpdwwxhu9EU_JiZCqYUbyFUnfeigD0C-HOGWMwdGtC93ZdT7sx7TfQaRXMIb0hm7pd4wljOE3UogdvcI-QNsjfR_SAPkXZupTpuMO6bYULGXAONLkZzBCTy-m6Oac-Jw88dAXfHE3T8mPiw_X55-qy68fP59vLyvXaD5W4HytWtlqoze1NqI2nQNhoFVQd2iwQ6mV47r1XopNq5Q0xvm2VQ478F0jT8nrY-4-p9sJy2iHUBz2PURMU7FcNlxxxrSY0fqIupxKyejtPof5pYPlzC6q7b1qu6i2R9Xz2qu7hqkdsPu3dO92Bt4dgRBnMwP8Sbnv7AiHPmWfIbpQlvgHK97-l7BD6Medg4z2Jk159loevvEvslKi6g</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Zhao, Jianxing</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Plasma Kynurenic Acid/Tryptophan Ratio: A Sensitive and Reliable Biomarker for the Assessment of Renal Function</title><author>Zhao, Jianxing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-acf46b3b8987489249dca29ab6a4de9ede386c18bff327b66399cfbb6cedafd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Chromatography, High Pressure Liquid</topic><topic>chronic kidney disease</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - complications</topic><topic>Kidney Function Tests</topic><topic>kynurenic acid</topic><topic>Kynurenic Acid - blood</topic><topic>kynurenine</topic><topic>Kynurenine - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>plasma</topic><topic>renal function</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>tryptophan</topic><topic>Tryptophan - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Jianxing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Jianxing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Kynurenic Acid/Tryptophan Ratio: A Sensitive and Reliable Biomarker for the Assessment of Renal Function</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>35</volume><issue>5</issue><spage>648</spage><epage>653</epage><pages>648-653</pages><issn>0886-022X</issn><eissn>1525-6049</eissn><abstract>Background: Decreased tryptophan (TRP) and increased kynurenine (KYN) and kynurenic acid (KYNA) in blood have been reported in patients and experimental animals with renal diseases. We investigated if these compounds could be used as new biomarkers for the assessment of renal function. Methods: Eighty hospitalized hypertensive patients (20 with chronic kidney disease (CKD), and other 60 were considered as control) were enrolled for the investigation. Plasma TRP, KYN, and KYNA were determined by high-performance liquid chromatography. Change rate (CR) was employed to evaluate the sensitivity of the parameters of renal function. Results: CR of plasma KYNA/TRP ratio (+103%) was much higher than the CRs of blood urea nitrogen (+44%), serum creatinine (+56%) and estimated glomerular filtration rate (-35%). Plasma KYNA/TRP ratio was in close relationship with blood urea nitrogen (r = 0.622), serum creatinine (r = 0.797), urine micro-albumin/24-h (r = 0.518) and estimated glomerular filtration rate (r = -0.662), respectively, with all p-values <0.001. Conclusions: Plasma KYNA/TRP ratio was sensitive and reliable to indicate renal function and could be used as a new biomarker to assess the risk or presence of kidney disease.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>23650931</pmid><doi>10.3109/0886022X.2013.790301</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Renal failure, 2013-01, Vol.35 (5), p.648-653 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Chromatography, High Pressure Liquid chronic kidney disease Female Humans Hypertension - blood Hypertension - complications Kidney Function Tests kynurenic acid Kynurenic Acid - blood kynurenine Kynurenine - blood Male Middle Aged plasma renal function Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications tryptophan Tryptophan - blood |
| title | Plasma Kynurenic Acid/Tryptophan Ratio: A Sensitive and Reliable Biomarker for the Assessment of Renal Function |
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