Expression of E-cadherin in primary endometrial carcinomas: clinicopathological and immunohistochemical analysis of 30 cases
Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes. The purpose of this study was to examine the distribution of E-cadherin immunohistochemical expression in specimens from primary endometrial carcinomas and its relation to cl...
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| Veröffentlicht in: | European journal of gynaecological oncology 2013, Vol.34 (1), p.31 |
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| creator | Varras, M Skafida, E Vasilakaki, T Anastasiadis, A Akrivis, C Vrachnis, N Nikolopoulos, G |
| description | Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes.
The purpose of this study was to examine the distribution of E-cadherin immunohistochemical expression in specimens from primary endometrial carcinomas and its relation to classical clinicopathological prognostic factors.
Surgically-resected tissues of 30 patients with primary endometrial carcinomas were studied. Histological type and grade, depth of myometrial invasion, lymph-vascular space invasion, fallopian tube or ovarian invasion, and the presence of tumoral necrosis were evaluated. Immunohistochemical examination was performed on deparaffinized four-microm-thick sections.
The mean age of patients was 65 years (+/- 11.41). The 63.54% of carcinomas were moderately/poorly differentiated. No statistical correlation was found between the score or intensity of E-cadherin immunohistochemical staining (strong or moderate positive expression) and the clinicopathological factors tested.
The association of E-cadherin immunoreactivity with the standard clinicopathological factors seemed to be contradictory. The classical clinicopathological factors remain the most important prognostic parameters. |
| format | Article |
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The purpose of this study was to examine the distribution of E-cadherin immunohistochemical expression in specimens from primary endometrial carcinomas and its relation to classical clinicopathological prognostic factors.
Surgically-resected tissues of 30 patients with primary endometrial carcinomas were studied. Histological type and grade, depth of myometrial invasion, lymph-vascular space invasion, fallopian tube or ovarian invasion, and the presence of tumoral necrosis were evaluated. Immunohistochemical examination was performed on deparaffinized four-microm-thick sections.
The mean age of patients was 65 years (+/- 11.41). The 63.54% of carcinomas were moderately/poorly differentiated. No statistical correlation was found between the score or intensity of E-cadherin immunohistochemical staining (strong or moderate positive expression) and the clinicopathological factors tested.
The association of E-cadherin immunoreactivity with the standard clinicopathological factors seemed to be contradictory. The classical clinicopathological factors remain the most important prognostic parameters.</description><identifier>ISSN: 0392-2936</identifier><identifier>PMID: 23589996</identifier><language>eng</language><publisher>Italy</publisher><subject>Aged ; Cadherins - analysis ; Cadherins - physiology ; Endometrial Neoplasms - chemistry ; Endometrial Neoplasms - pathology ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Prognosis</subject><ispartof>European journal of gynaecological oncology, 2013, Vol.34 (1), p.31</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23589996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varras, M</creatorcontrib><creatorcontrib>Skafida, E</creatorcontrib><creatorcontrib>Vasilakaki, T</creatorcontrib><creatorcontrib>Anastasiadis, A</creatorcontrib><creatorcontrib>Akrivis, C</creatorcontrib><creatorcontrib>Vrachnis, N</creatorcontrib><creatorcontrib>Nikolopoulos, G</creatorcontrib><title>Expression of E-cadherin in primary endometrial carcinomas: clinicopathological and immunohistochemical analysis of 30 cases</title><title>European journal of gynaecological oncology</title><addtitle>Eur J Gynaecol Oncol</addtitle><description>Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes.
The purpose of this study was to examine the distribution of E-cadherin immunohistochemical expression in specimens from primary endometrial carcinomas and its relation to classical clinicopathological prognostic factors.
Surgically-resected tissues of 30 patients with primary endometrial carcinomas were studied. Histological type and grade, depth of myometrial invasion, lymph-vascular space invasion, fallopian tube or ovarian invasion, and the presence of tumoral necrosis were evaluated. Immunohistochemical examination was performed on deparaffinized four-microm-thick sections.
The mean age of patients was 65 years (+/- 11.41). The 63.54% of carcinomas were moderately/poorly differentiated. No statistical correlation was found between the score or intensity of E-cadherin immunohistochemical staining (strong or moderate positive expression) and the clinicopathological factors tested.
The association of E-cadherin immunoreactivity with the standard clinicopathological factors seemed to be contradictory. The classical clinicopathological factors remain the most important prognostic parameters.</description><subject>Aged</subject><subject>Cadherins - analysis</subject><subject>Cadherins - physiology</subject><subject>Endometrial Neoplasms - chemistry</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Middle Aged</subject><subject>Prognosis</subject><issn>0392-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UF9LwzAczIPi5vQrSL5AIUvSpPFNRv0DA1_2Pn5NfrWRJilJBw788E6scHBwB3fcXZE1E4ZX3Ai1IrelfDImpVb8hqy4qBtjjFqT7_ZryliKT5GmnraVBTdg9pFeMGUfIJ8pRpcCztnDSC1k62MKUB6pHX30Nk0wD2lMH95efIiO-hBOMQ2-zMkOGBYdxnPx5bdFsEtMwXJHrnsYC94vvCGH5_awe6327y9vu6d9NW11M1eCMeRCK2UEojOOWyklrw0g2F5a1gB2vK-1lhq161SvXaM5g27bIBMgNuThL3Y6dQHdcZl1_H9B_ACRyFtX</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Varras, M</creator><creator>Skafida, E</creator><creator>Vasilakaki, T</creator><creator>Anastasiadis, A</creator><creator>Akrivis, C</creator><creator>Vrachnis, N</creator><creator>Nikolopoulos, G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>2013</creationdate><title>Expression of E-cadherin in primary endometrial carcinomas: clinicopathological and immunohistochemical analysis of 30 cases</title><author>Varras, M ; Skafida, E ; Vasilakaki, T ; Anastasiadis, A ; Akrivis, C ; Vrachnis, N ; Nikolopoulos, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p178t-300e2376693eed9d2c444259aeacf4c08aeb2f57747e7db6f7d8720ab18e03a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Cadherins - analysis</topic><topic>Cadherins - physiology</topic><topic>Endometrial Neoplasms - chemistry</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Middle Aged</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Varras, M</creatorcontrib><creatorcontrib>Skafida, E</creatorcontrib><creatorcontrib>Vasilakaki, T</creatorcontrib><creatorcontrib>Anastasiadis, A</creatorcontrib><creatorcontrib>Akrivis, C</creatorcontrib><creatorcontrib>Vrachnis, N</creatorcontrib><creatorcontrib>Nikolopoulos, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European journal of gynaecological oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Varras, M</au><au>Skafida, E</au><au>Vasilakaki, T</au><au>Anastasiadis, A</au><au>Akrivis, C</au><au>Vrachnis, N</au><au>Nikolopoulos, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of E-cadherin in primary endometrial carcinomas: clinicopathological and immunohistochemical analysis of 30 cases</atitle><jtitle>European journal of gynaecological oncology</jtitle><addtitle>Eur J Gynaecol Oncol</addtitle><date>2013</date><risdate>2013</risdate><volume>34</volume><issue>1</issue><spage>31</spage><pages>31-</pages><issn>0392-2936</issn><abstract>Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes.
The purpose of this study was to examine the distribution of E-cadherin immunohistochemical expression in specimens from primary endometrial carcinomas and its relation to classical clinicopathological prognostic factors.
Surgically-resected tissues of 30 patients with primary endometrial carcinomas were studied. Histological type and grade, depth of myometrial invasion, lymph-vascular space invasion, fallopian tube or ovarian invasion, and the presence of tumoral necrosis were evaluated. Immunohistochemical examination was performed on deparaffinized four-microm-thick sections.
The mean age of patients was 65 years (+/- 11.41). The 63.54% of carcinomas were moderately/poorly differentiated. No statistical correlation was found between the score or intensity of E-cadherin immunohistochemical staining (strong or moderate positive expression) and the clinicopathological factors tested.
The association of E-cadherin immunoreactivity with the standard clinicopathological factors seemed to be contradictory. The classical clinicopathological factors remain the most important prognostic parameters.</abstract><cop>Italy</cop><pmid>23589996</pmid></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Cadherins - analysis Cadherins - physiology Endometrial Neoplasms - chemistry Endometrial Neoplasms - pathology Female Humans Immunohistochemistry Middle Aged Prognosis |
| title | Expression of E-cadherin in primary endometrial carcinomas: clinicopathological and immunohistochemical analysis of 30 cases |
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