Alpha-1 Antitrypsin Augmentation Therapy and Biomarkers of Elastin Degradation

AbstractBackground: Intravenous alpha-1 antitrypsin protein (AAT) augmentation is a prescribed therapy for severe, genetically determined, alpha-1 antitrypsin deficiency (AATD), a genetic basis for pulmonary emphysema. AAT, a predominant systemic inhibitor of neutrophil elastase thus far has not bee...

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Veröffentlicht in:	Chronic obstructive pulmonary disease 2013-08, Vol.10 (4), p.473-481
Hauptverfasser:	Ma, Shuren, Lin, Yong Y., He, Jiangtao, Rouhani, Farshid N., Brantly, Mark, Turino, Gerard M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged alpha 1-Antitrypsin - administration & dosage alpha 1-Antitrypsin - therapeutic use alpha 1-Antitrypsin Deficiency - drug therapy alpha 1-Antitrypsin Deficiency - genetics alpha 1-Antitrypsin Deficiency - metabolism alpha-1 antitrypsin deficiency (AATD) augmentation therapy Biomarkers - metabolism Bronchoalveolar Lavage Fluid Elastin - metabolism elastin biomarkers Female Homozygote Humans Isodesmosine - blood Isodesmosine - metabolism Isodesmosine - urine Leukocyte Elastase - antagonists & inhibitors Leukocyte Elastase - metabolism Male Middle Aged neutrophil elastase Phenotype Trypsin Inhibitors - administration & dosage Trypsin Inhibitors - therapeutic use
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