Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ(9)-tetrahydrocannabinol in human breast cancer cells

To investigate gene(s) being regulated by ∆(9)-tetrahydrocannabinol (∆(9)-THC), we performed DNA microarray analysis of human breast cancer MDA-MB-231 cells, which are poorly differentiated breast cancer cells, treated with ∆(9)-THC for 48 hr at an IC50 concentration of approximately 25 µM. Among th...

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Veröffentlicht in:	Journal of toxicological sciences 2013, Vol.38 (2), p.305
Hauptverfasser:	Takeda, Shuso, Harada, Mari, Su, Shengzhong, Okajima, Shunsuke, Miyoshi, Hiroko, Yoshida, Kazutaka, Nishimura, Hajime, Okamoto, Yoshiko, Amamoto, Toshiaki, Watanabe, Kazuhito, Omiecinski, Curtis J, Aramaki, Hironori
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Differentiation - drug effects Dronabinol - pharmacology Female Humans Mixed Function Oxygenases - genetics Mixed Function Oxygenases - physiology Oligonucleotide Array Sequence Analysis PPAR alpha - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Transcriptional Activation - drug effects Tumor Cells, Cultured Up-Regulation
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