Substrate selectivity in arginine-dependent acid resistance in enteric bacteria

To successfully colonize the human gut, enteric bacteria must activate acid resistance systems to survive the extreme acidity (pH 1.5–3.5) of the stomach. The antiporter AdiC is the master orchestrator of the arginine-dependent system. Upon acid shock, it imports extracellular arginine (Arg) into th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-04, Vol.110 (15), p.5893-5897
Hauptverfasser:	Tsai, Ming-Feng, Miller, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidity Amino Acid Transport Systems - chemistry Antiporters Antiporters - chemistry Arginine - chemistry Bacteria Bacterial Proteins - chemistry Biochemistry Biological Sciences Biological Transport Carbon Isotopes - chemistry Catalysis Chemical bonds Citrulline - chemistry Crystal structure Cytoplasm Enterobacteriaceae Enterobacteriaceae - physiology Escherichia coli Hydrogen-Ion Concentration Liposomes Liposomes - chemistry Potassium - chemistry Protein Conformation Protons Stomach Substrate Specificity
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