Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase

Homology-directed repair (HDR) is a critical pathway for the repair of DNA double-strand breaks (DSBs) in mammalian cells. Efficient HDR is thought to be crucial for maintenance of genomic integrity during organismal development and tumor suppression. However, most mammalian HDR studies have focused...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-04, Vol.110 (14), p.5564-5569
Hauptverfasser:	Kass, Elizabeth M., Helgadottir, Hildur R., Chen, Chun-Chin, Barbera, Maria, Wang, Raymond, Westermark, Ulrica K., Ludwig, Thomas, Moynahan, Mary Ellen, Jasin, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Ataxia Telangiectasia Mutated Proteins Biological Sciences BRCA1 Protein - metabolism Breast cancer Cell cycle Cell Cycle Proteins - metabolism Cell lines Cells Deoxyribonucleases, Type II Site-Specific DNA DNA Breaks, Double-Stranded DNA damage DNA repair DNA-Binding Proteins - metabolism Electroporation Epithelial cells Fibroblasts Flow Cytometry Genetic recombination Germ cells Green Fluorescent Proteins - metabolism Kinases Mice Models, Animal Mutation Protein Serine-Threonine Kinases - metabolism Recombinational DNA Repair - physiology Repetitive Sequences, Nucleic Acid - genetics Saccharomyces cerevisiae Proteins Somatic cells Tumor Suppressor Proteins - metabolism
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