Surface modification of implants in long bone
Coatings of orthopedic implants are investigated to improve the osteoinductive and osteoconductive properties of the implant surfaces and thus to enhance periimplant bone formation. By applying coatings that mimic the extracellular matrix a favorable environment for osteoblasts, osteoclasts and thei...
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| Veröffentlicht in: | Biomatter (Austin, TX) TX), 2012-07, Vol.2 (3), p.149-157 |
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| creator | Förster, Yvonne Rentsch, Claudia Schneiders, Wolfgang Bernhardt, Ricardo Simon, Jan C. Worch, Hartmut Rammelt, Stefan |
| description | Coatings of orthopedic implants are investigated to improve the osteoinductive and osteoconductive properties of the implant surfaces and thus to enhance periimplant bone formation. By applying coatings that mimic the extracellular matrix a favorable environment for osteoblasts, osteoclasts and their progenitor cells is provided to promote early and strong fixation of implants. It is known that the early bone ongrowth increases primary implant fixation and reduces the risk of implant failure. This review presents an overview of coating titanium and hydroxyapatite implants with components of the extracellular matrix like collagen type I, chondroitin sulfate and RGD peptide in different small and large animal models. The influence of these components on cells, the inflammation process, new bone formation and bone/implant contact is summarized. |
| doi_str_mv | 10.4161/biom.21563 |
| format | Article |
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By applying coatings that mimic the extracellular matrix a favorable environment for osteoblasts, osteoclasts and their progenitor cells is provided to promote early and strong fixation of implants. It is known that the early bone ongrowth increases primary implant fixation and reduces the risk of implant failure. This review presents an overview of coating titanium and hydroxyapatite implants with components of the extracellular matrix like collagen type I, chondroitin sulfate and RGD peptide in different small and large animal models. 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By applying coatings that mimic the extracellular matrix a favorable environment for osteoblasts, osteoclasts and their progenitor cells is provided to promote early and strong fixation of implants. It is known that the early bone ongrowth increases primary implant fixation and reduces the risk of implant failure. This review presents an overview of coating titanium and hydroxyapatite implants with components of the extracellular matrix like collagen type I, chondroitin sulfate and RGD peptide in different small and large animal models. The influence of these components on cells, the inflammation process, new bone formation and bone/implant contact is summarized.</description><subject>Animals</subject><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Bone and Bones - pathology</subject><subject>bone healing</subject><subject>Bone Substitutes</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>chondroitin sulfate</subject><subject>Chondroitin Sulfates - chemistry</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Collagen - chemistry</subject><subject>collagen type I</subject><subject>Cycle</subject><subject>Cytokines - metabolism</subject><subject>Durapatite - chemistry</subject><subject>Extracellular Matrix - metabolism</subject><subject>Femur - pathology</subject><subject>Humans</subject><subject>hyaluronic acid</subject><subject>hydroxyapatite</subject><subject>implants</subject><subject>Implants, Experimental</subject><subject>Landes</subject><subject>Oligopeptides - chemistry</subject><subject>Organogenesis</subject><subject>Osseointegration</subject><subject>Osteoblasts - cytology</subject><subject>Osteoclasts - cytology</subject><subject>Prostheses and Implants</subject><subject>Proteins</subject><subject>Rats</subject><subject>RGD peptide</subject><subject>Special Focus Review</subject><subject>Tibia - pathology</subject><subject>titanium</subject><subject>Titanium - chemistry</subject><issn>2159-2527</issn><issn>2159-2535</issn><issn>2159-2535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNqFkF1LHTEQhkNpqXL0pj9A9lIKa_Oxk929EazYKlgEe3odZvOhKbvJabLH4r9vjkdPWyg0NxOY531n5iXkHaMnDZPsw-DjdMIZSPGK7Jfa1xwEvN79ebtHDnP-TsuDpuMc3pI9LoC2nZT7pP66Tg61raZovPMaZx9DFV3lp9WIYc6VD9UYw101xGAPyBuHY7aHz3VBvn26WJ5f1tc3n6_Oz65r3YhG1NhpsEixBy6MGAYAhL4xAB3vHUPRtoL2TccaIU0hjeX9YJygTFMJg5ZiQU63vqv1MFmjbZgTjmqV_ITpUUX06u9O8PfqLj4oAU3fya4YHD8bpPhjbfOsJp-1HctJNq6zYoJ1tOctbQv6fovqFHNO1u3GMKo2EatNxOop4gIf_bnYDn0JtAByC5RJxuYizdrboO1vlDL-8ermy9lyeXFLKYNbtSrHL0j7H-FmDZxnmxSm2evR7naCrdIHF9OEP2MajZrxcYzJJQzaZyX-ccsvPVqwTw</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Förster, Yvonne</creator><creator>Rentsch, Claudia</creator><creator>Schneiders, Wolfgang</creator><creator>Bernhardt, Ricardo</creator><creator>Simon, Jan C.</creator><creator>Worch, Hartmut</creator><creator>Rammelt, Stefan</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120701</creationdate><title>Surface modification of implants in long bone</title><author>Förster, Yvonne ; 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By applying coatings that mimic the extracellular matrix a favorable environment for osteoblasts, osteoclasts and their progenitor cells is provided to promote early and strong fixation of implants. It is known that the early bone ongrowth increases primary implant fixation and reduces the risk of implant failure. This review presents an overview of coating titanium and hydroxyapatite implants with components of the extracellular matrix like collagen type I, chondroitin sulfate and RGD peptide in different small and large animal models. The influence of these components on cells, the inflammation process, new bone formation and bone/implant contact is summarized.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>23507866</pmid><doi>10.4161/biom.21563</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Binding Biology Bioscience Bone and Bones - pathology bone healing Bone Substitutes Calcium Cancer Cell Cell Differentiation Cell Proliferation chondroitin sulfate Chondroitin Sulfates - chemistry Coated Materials, Biocompatible - chemistry Collagen - chemistry collagen type I Cycle Cytokines - metabolism Durapatite - chemistry Extracellular Matrix - metabolism Femur - pathology Humans hyaluronic acid hydroxyapatite implants Implants, Experimental Landes Oligopeptides - chemistry Organogenesis Osseointegration Osteoblasts - cytology Osteoclasts - cytology Prostheses and Implants Proteins Rats RGD peptide Special Focus Review Tibia - pathology titanium Titanium - chemistry |
| title | Surface modification of implants in long bone |
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