The clinical utility of genetic risk variants in type 2 diabetes

The clinical utility of genetic risk variants in type 2 diabetes

Background: Type 2 diabetes is one of the first success stories in the application of genome-wide linkage and association studies to find genetic variants contributing to its risk. Objective: Are the genetic markers found so far useful in predicting which individuals are more likely to develop type...

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Veröffentlicht in:Expert opinion on medical diagnostics 2008-08, Vol.2 (8), p.991-1002
Hauptverfasser: Gulcher, Jeff, Stefansson, Kari
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Sprache:eng
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impaired fasting glucose
prediabetes
prevention
risk
TCF7L2
type 2 diabetes
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Stefansson, Kari
description Background: Type 2 diabetes is one of the first success stories in the application of genome-wide linkage and association studies to find genetic variants contributing to its risk. Objective: Are the genetic markers found so far useful in predicting which individuals are more likely to develop type 2 diabetes? Can they find which patients with prediabetes are more likely to convert to type 2 diabetes and therefore may benefit the most from lifestyle or pharmacologic prevention strategies? Methods: The literature pertaining to the discovery and replications of genes contributing to type 2 diabetes was focused on. Results/conclusion: Substantial risk for type 2 diabetes is represented by the top 8 genes, including TCF7L2, and in certain circumstances may be useful for prevention strategies targeted to those with highest risk.
doi_str_mv 10.1517/17530059.2.8.991
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source Taylor & Francis Online
subjects impaired fasting glucose
prediabetes
prevention
risk
TCF7L2
type 2 diabetes
title The clinical utility of genetic risk variants in type 2 diabetes
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