Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4

Human ES cells (hESC) exposed to bone morphogenic protein 4 (BMP4) in the absence of FGF2 have become widely used for studying trophoblast development, but the soundness of this model has been challenged by others, who concluded that differentiation was primarily toward mesoderm rather than trophobl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-03, Vol.110 (13), p.E1212-E1221
Hauptverfasser:	Amita, Mitsuyoshi, Adachi, Katsuyuki, Alexenko, Andrei P, Sinha, Sunilima, Schust, Danny J, Schulz, Laura C, Roberts, R Michael, Ezashi, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Activins - metabolism Animals Antigens, Differentiation - biosynthesis Biological Sciences Bone Morphogenetic Protein 4 - metabolism Bone Morphogenetic Protein 4 - pharmacology Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line Culture Media, Conditioned Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Fibroblast Growth Factor 2 - metabolism Humans Keratin-7 - biosynthesis Mice PNAS Plus Progesterone Proteins Rodents Signal Transduction - physiology Stem cells Trophoblasts - cytology Trophoblasts - metabolism
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