Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells

Previous studies demonstrated that certain glycosphingolipids (GSLs) are involved in various cell functions, such as cell growth and motility. Recent studies showed changes in GSL expression during differentiation of human embryonic stem cells; however, little is known about expression profiles of G...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-03, Vol.110 (13), p.4968-4973
Hauptverfasser:	Liang, Yuh-Jin, Ding, Yao, Levery, Steven B., Lobaton, Marlin, Handa, Kazuko, Hakomori, Sen-itiroh
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell growth Cell Line, Tumor Cell lines Cell Movement - genetics Chemotherapy Embryonic stem cells Epithelial cells Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genotype & phenotype Glucosyltransferases - biosynthesis Glucosyltransferases - genetics Glycosphingolipids Glycosphingolipids - biosynthesis Humans Lipids Mass spectrometry Mesenchymal stem cells Messenger RNA Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Stem cells Tumors
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